[1]杨芷 王明 孙嘉.肥胖相关基因的新进展[J].国际内分泌代谢杂志,2018,38(04):262-266.[doi:10.3760/cma.j.issn.1673-4157.2018.04.011]
 Yang Zhi*,Wang Ming,Sun Jia.*.Recent progress of obesity-related genes[J].International Journal of Endocrinology and Metabolism,2018,38(04):262-266.[doi:10.3760/cma.j.issn.1673-4157.2018.04.011]
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肥胖相关基因的新进展()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
38
期数:
2018年04期
页码:
262-266
栏目:
基础研究
出版日期:
2018-07-20

文章信息/Info

Title:
Recent progress of obesity-related genes
作者:
杨芷 王明 孙嘉
510280 广州,南方医科大学第二临床医学院(杨芷),南方医科大学珠江医院中西医结合肾病中心(王明),内分泌与代谢科(孙嘉)
Author(s):
Yang Zhi* Wang Ming Sun Jia.*
The Second College of Clinical Medicine, Southern Medical University, Guangzhou 510280, China
关键词:
肥胖 基因 单核苷酸多态性 DNA甲基化
Keywords:
Obesity Gene Single nucleotide polymorphism DNA methylation
DOI:
10.3760/cma.j.issn.1673-4157.2018.04.011
摘要:
肥胖根据基因突变的类型不同可分为单基因肥胖与多基因肥胖。单基因肥胖的发病机制已经基本阐明,但多基因肥胖的作用机制尚不明晰。全基因组关联分析利用基因的单核苷酸多态性确定了许多多基因肥胖易感基因,并发现一些单基因肥胖基因同时也与多基因肥胖有关。肥胖相关基因通过表观遗传学修饰、神经内分泌、免疫炎性反应等多种途径上调食物摄取并下调能量消耗。此外,它们之间的多基因相互效应可能是肥胖的重要发病机制。
Abstract:
Obesity can be divided into monogenic obesity and polygenic obesity according to different types of gene mutations. Mechanisms have been already known in monogenic obesity, while those remain unclear in polygenic one. Using single-nucleotide polymorphism, the genome-wide association study has identified many susceptibility genes of polygenic obesity, and found that some monogenic obesity genes are related to polygenic obesity at the same time. Obesity-related genes may increase the intake and decrease the consumption through various pathways such as epigenetic modification, neuroendocrine signal system and immune-inflammatory reactions. Besides, polygenic effects exist among these genes, which may play a pivotal role in the pathogenesis of monogenic obesity.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金(81670783,81774035); 广东省自然科学基金(2017A030313473); 南方医科大学2017年国家级大学生创新创业训练计划项目(201712121049)
通信作者:孙嘉,Email:sunjia@smu.edu.cn
更新日期/Last Update: 2018-04-30