[1]文钟,童晓霞,谢文光,等.三磷酸腺苷结合盒转运蛋白G2与痛风/高尿酸血症[J].国际内分泌代谢杂志,2017,37(06):422-425.
 Wen Zhong*,Tong Xiaoxia,Xie Wenguang,et al.ATP-binding cassette sub-family G member 2 and gout/hyperuricemia[J].International Journal of Endocrinology and Metabolism,2017,37(06):422-425.
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三磷酸腺苷结合盒转运蛋白G2与痛风/高尿酸血症()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
37
期数:
2017年06期
页码:
422-425
栏目:
综述
出版日期:
2017-11-20

文章信息/Info

Title:
ATP-binding cassette sub-family G member 2 and gout/hyperuricemia
作者:
文钟童晓霞谢文光青玉凤钟晓武周京国
637000 南充,川北医学院附属医院风湿免疫科(文钟,童晓霞,青玉凤,周京国),医学研究中心(谢文光),检验科(钟晓武); 637000 南充,川北医学院风湿免疫研究所(谢文光); 610083 成都医学院(周京国)
Author(s):
Wen Zhong* Tong Xiaoxia Xie Wenguang Qing Yufeng Zhong Xiaowu Zhou Jingguo.
*Department of Rheumatology and Immunology, The North Sichuan Medical College, Nanchong 637000 China
关键词:
尿酸 高尿酸血症 痛风 三磷酸腺苷结合盒转运蛋白G2 ABC转运蛋白超家族 遗传多态性
Keywords:
Uric acid Hyperuricemia Gout ATP-binding cassette sub-family G member 2 ABC transporter superfamily Genetic polymorphism
文献标志码:
A
摘要:
三磷酸腺苷结合盒转运蛋白G2(ABCG2)是ABC转运蛋白超家族成员之一,编码基因位于4号染色体上,为定位于细胞膜的转运蛋白,在肝、肾、肠等组织广泛表达,具有转运尿酸的功能,其功能异常会导致尿酸排泄减少。目前已经发现,多种单基因多态性影响ABCG2的尿酸转运功能,从而引起高尿酸血症和痛风。所以研究ABCG2靶点药物意义重大,但仍需进一步研究。
Abstract:
ATP-binding cassette sub-family G member 2(ABCG2)is one of the members of the ATP-binding cassette transporter superfamily. The coding gene is located on chromosome 4 and it is a transporter located in the cell membrane. It is widely expressed in liver, kidney and intestine. ABCG2 has the function of transporting uric acid, abnormal function of it can lead to decreasion of uric acid excretion. It has been found that multiple single-gene polymorphisms affect the uric acid transport function of ABCG2 and cause hyperuricemia and gout. Therefore, research on ABCG2 target drug is significant, but it still need further study.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助项目(81670801); 国家卫计委公益性行业科研专项(201502024); 四川省教育厅资助科研项目(16CZ0023)
通信作者:周京国,Email: jgzhou@nsmccmc.edu.cn
更新日期/Last Update: 2017-11-30