[1]黄爱洁,周莹,符金香,等.青春期多囊卵巢综合征的诊治进展[J].国际内分泌代谢杂志,2016,36(05):338-341.[doi:10.3760/cma.j.issn.1673-4157.2016.05.14]
 Huang Aijie,Zhou Ying,Fu Jinxiang,et al.Diagnosis and treatment of polycystic ovary syndrome in adolescence[J].International Journal of Endocrinology and Metabolism,2016,36(05):338-341.[doi:10.3760/cma.j.issn.1673-4157.2016.05.14]
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青春期多囊卵巢综合征的诊治进展()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
36
期数:
2016年05期
页码:
338-341
栏目:
综述
出版日期:
2016-09-20

文章信息/Info

Title:
Diagnosis and treatment of polycystic ovary syndrome in adolescence
作者:
黄爱洁周莹符金香龚颖芸付真真杨盼盼叶正芹胡文周红文
210029 南京医科大学第一附属医院内分泌科
Author(s):
Huang Aijie Zhou Ying Fu Jinxiang Gong Yingyun Fu Zhenzhen Yang Panpan Ye Zhengqin Hu Wen Zhou Hongwen
Department of Endocrinology and Metabolism, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
关键词:
青春期 多囊卵巢综合征 诊断标准 治疗
Keywords:
Adolescence Polycystic ovary syndrome Diagnostic criteria Treatment
DOI:
10.3760/cma.j.issn.1673-4157.2016.05.14
摘要:
青春期女性机体迅速生长发育,内分泌系统逐渐发育成熟,毛发生长、月经来潮等生理改变容易与多 囊卵巢综合征(PCOS)的临床表现重叠,影响PCOS的诊断。目前关于青春期PCOS尚无统一的诊断标准,多数专家建 议把高雄激素血症和月经紊乱(初潮建立后2年)纳入诊断标准。目前尚无规范的治疗管理,抗雄激素治疗、调节 月经周期是主要的治疗,对于肥胖的患者需要给予减重治疗,伴随相关合并症者给予对症治疗。
Abstract:
Adolescence is a period of rapid growth and development, in which the endocrine system is gradually mature. The physiologic changes of puberty including hair growth and menses could overlap with the manifestations of polycystic ovary syndrome(PCOS), which make it difficult to diagnose PCOS. Nevertheless, there is no uniform diagnostic criteria for PCOS in adolescence, most experts agreed that the criteria should include hyperandrogenaemia and oligoamenorrhea(menstruation>2 years). Moreover, there are no standard management and treatment for this group, the major treatments are regarding hyperandrogenaemia and oligoamenorrhea. Obese adolescents with PCOS may be motivated to lose weight. Complication should be addressed as well.

参考文献/References:

[1] Franks S. Polycystic ovary syndrome[J].N Engl J Med,1995,333(13):853-861.
[2] Johnson T, Kaplan L, Ouyang P, et al. Evidence-based methodology workshop on polycystic ovary syndrome. http://prevention.nih.gov/docs/programs/pcos/Final Report.pdf. Maryland: National Institutes of Health, 2012.
[3] Zawadzki JK. Diagnostic criteria for polycystic ovary syndrome: towards a rational approach. Dunaif A,eds.Polycystic ovary syndrome[M].Boston: Blackwell Scientific,1995:377-384.
[4] Rotterdam ESHRE/ASRM-Sponsored PCOS consensus workshop group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome(PCOS)[J].Hum Reprod,2004,19(1):41-47.
[5] Azziz R, Carmina E, Dewailly D,et al. Positions statement: criteria for defining polycystic ovary syndrome as a predominantly hyperandrogenic syndrome: an Androgen Excess Society guideline[J].J Clin Endocrinol Metab,2006,91(11):4237-4245.
[6] Nader S. Hyperandrogenism during puberty in the development of polycystic ovary syndrome [J].Fertil Steril,2013,100(1):39-42. DOI: 10.1016/j.fertnstert.2013.03.013.
[7] Merino PM, Codner E, Cassorla F. A rational approach to the diagnosis of polycystic ovarian syndrome during adolescence[J].Arq Bras Endocrinol Metabol,2011,55(8):590-598.
[8] Rosenfield RL. Clinical review: Adolescent anovulation: maturational mechanisms and implications[J].J Clin Endocrinol Metab,2013,98(9):3572-3583. DOI: 10.1210/jc.2013-1770.
[9] Ibánez L, Ong KK, López-Bermejo A, et al. Hyperinsulinaemic androgen excess in adolescent girls[J].Nat Rev Endocrinol,2014,10(8):499-508. DOI: 10.1038/nrendo.2014.58.
[10] Amsterdam ESHRE/ASRM-Sponsored 3rd PCOS Consensus Workshop Group. Consensus on women's health aspects of polycystic ovary syndrome(PCOS)[J]. Hum Reprod,2012,27(1):14-24. DOI: 10.1093/humrep/der396.
[11] Legro RS, Arslanian SA, Ehrmann DA,et al. Diagnosis and treatment of polycystic ovary syndrome: an Endocrine Society clinical practice guideline[J].J Clin Endocrinol Metab,2013,98 (12):4565-4592. DOI: 10.1210/jc.2013-2350.
[12] Flannery CA, Rackow B, Cong X,et al. Polycystic ovary syndrome in adolescence: impaired glucose tolerance occurs across the spectrum of BMI[J].Pediatr Diabetes,2013,14(1):42-49. DOI: 10.1111/j.1399-5448.2012.00902.x.
[13] Moran LJ, Hutchison SK, Norman RJ, et al. Lifestyle changes in women with polycystic ovary syndrome[J]. Cochrane Database Syst Rev, 2011(7):Cd007506. DOI: 10.1002/14651858.CD007506.pub3.
[14] Lass N, Kleber M, Winkel K,et al. Effect of lifestyle intervention on features of polycystic ovarian syndrome, metabolic syndrome, and intima-media thickness in obese adolescent girls[J].J Clin Endocrinol Metab,2011,96(11):3533-3540. DOI: 10.1210/jc.2011-1609.
[15] Abazar E, Taghian F, Mardanian F, et al. Effects of aerobic exercise on plasma lipoproteins in overweight and obese women with polycystic ovary syndrome[J].Adv Biomed Res,2015,4:68. DOI: 10.4103/2277-9175.153892.
[16] Kiddy DS, Hamilton-Fairley D, Bush A,et al. Improvement in endocrine and ovarian function during dietary treatment of obese women with polycystic ovary syndrome[J].Clin Endocrinol(Oxf), 1992,36(1):105-111.
[17] Ornstein RM, Copperman NM, Jacobson MS. Effect of weight loss on menstrual function in adolescents with polycystic ovary syndrome[J].J Pediatr Adolesc Gynecol,2011,24(3):161-165. DOI: 10.1016/j.jpag.2011.01.002.
[18] Hoeger K, Davidson K, Kochman L, et al. The impact of metformin, oral contraceptives, and lifestyle modification on polycystic ovary syndrome in obese adolescent women in two randomized, placebo-controlled clinical trials[J].J Clin Endocrinol Metab,2008,93(11):4299-4306. DOI: 10.1210/jc.2008-0461.
[19] Vitek W, Hoeger KM. Treatment of polycystic ovary syndrome in adolescence[J].Semin Reprod Med,2014,32(3):214-221. DOI: 10.1055/s-0034-1371093.
[20] Mathur R, Levin O, Azziz R. Use of ethinylestradiol/drospirenone combination in patients with the polycystic ovary syndrome[J].Ther Clin Risk Manag,2008,4(2):487-492.
[21] Pehlivanov B, Mitkov M. Efficacy of an oral contraceptive containing drospirenone in the treatment of women with polycystic ovary syndrome[J]. Eur J Contracept Reprod Health Care,2007,12(1):30-35.
[22] Guido M, Romualdi D, Giuliani M,et al. Drospirenone for the treatment of hirsute women with polycystic ovary syndrome: a clinical, endocrinological, metabolic pilot study[J].J Clin Endocrinol Metab,2004,89(6):2817-2823.
[23] Moghetti P, Tosi F, Tosti A, et al. Comparison of spironolactone, flutamide, and finasteride efficacy in the treatment of hirsutism: a randomized, double blind, placebo- controlled trial[J].J Clin Endocrinol Metab,2000,85(1):89-94.
[24] Castelo-Branco C, Del Pino M. Hepatotoxicity during low-dose flutamide treatment for hirsutism[J].Gynecol Endocrinol, 2009,25(7):419-422.
[25] Fauser BC, Tarlatzis BC, Rebar RW,et al. Consensus on women's health aspects of polycystic ovary syndrome(PCOS): the Amsterdam ESHRE/ASRM-Sponsored 3rd PCOS Consensus Workshop Group [J].Fertil Steril,2012,97(1):28-38.e25. DOI: 10.1016/j.fertnstert.2011.09.024.
[26] Glintborg D, Altinok ML, Mumm H, et al. Body composition is improved during 12 months' treatment with metformin alone or combined with oral contraceptives compared with treatment with oral contraceptives in polycystic ovary syndrome[J].J Clin Endocrinol Metab,2014,99(7):2584- 2591. DOI: 10.1210/jc.2014-1135.
[27] Escobar-Morreale HF, Carmina E, Dewailly D, et al. Epidemiology, diagnosis and management of hirsutism: a consensus statement by the Androgen Excess and Polycystic Ovary Syndrome Society[J].Hum Reprod Update,2012,18(2):146-170.DOI: 10.1093/humupd/dmr042.
[28] Ganie MA, Khurana ML, Nisar S,et al. Improved efficacy of low-dose spironolactone and metformin combination than either drug alone in the management of women with polycystic ovary syndrome(PCOS): a six-month, open-label randomized study[J].J Clin Endocrinol Metab,2013,98 (9):3599-3607. DOI: 10.1210/jc.2013-1040.
[29] Ibáñez L, Valls C, Ferrer A, et al. Additive effects of insulin-sensitizing and anti- androgen treatment in young, nonobese women with hyperinsulinism, hyperandrogenism, dyslipidemia, and anovulation[J].J Clin Endocrinol Metab,2002,87(6):2870-2874.
[30] Escobar-Morreale HF, Botella-Carretero JI, Alvarez-Blasco F, et al. The polycystic ovary syndrome associated with morbid obesity may resolve after weight loss induced by bariatric surgery[J].J Clin Endocrinol Metab,2005,90(12):6364-6369.
[31] Eid GM, Cottam DR, Velcu LM, et al. Effective treatment of polycystic ovarian syndrome with Roux-en-Y gastric bypass[J].Surg Obes Relat Dis,2005,1(2):77-80.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助项目(81170747) 通信作者:周红文,Email: drhongwenzhou@njmu.edu.cn
更新日期/Last Update: 2016-11-20