[1]郑辉,葛焕琦.网膜素对心血管系统的影响[J].国际内分泌代谢杂志,2016,36(04):261-266.[doi:10.3760/cma.j.issn.1673-4157.2016.04.12]
 Zheng Hui,Ge Huanqi.Effects of omentin on cardiovascular system[J].International Journal of Endocrinology and Metabolism,2016,36(04):261-266.[doi:10.3760/cma.j.issn.1673-4157.2016.04.12]
点击复制

网膜素对心血管系统的影响()
分享到:

《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
36
期数:
2016年04期
页码:
261-266
栏目:
综述
出版日期:
2016-07-20

文章信息/Info

Title:
Effects of omentin on cardiovascular system
作者:
郑辉葛焕琦
300457 天津,泰达国际心血管病医院内分泌科
Author(s):
Zheng HuiGe Huanqi
Department of Endocrinology, TEDA International Cardiovascular Disease Hospital,Tianjin 300457, China
关键词:
网膜素 心血管系统 脂肪因子
Keywords:
Omentin Cardiovascular system Adipokines
DOI:
10.3760/cma.j.issn.1673-4157.2016.04.12
摘要:
脂肪组织分泌的脂肪因子在包括冠心病、慢性心力衰竭等心血管系统疾病的发生、发展中起重要作用。近期大量临床研究发现,网膜素是具有心血管保护作用的少数脂肪因子之一。网膜素具有抗炎、保护内皮、抗氧化应激等多重心血管益处,同时对高血压、糖尿病、高血脂等心血管危险因素表现出有益作用。
Abstract:
Adipokines,secreted by adipose tissue, play important roles in the pathogenesis and development of cardiovascular diseases, including coronary heart disease, chronic heart failure, etc. Recently, a large number of clinical studies have found that omentin is one of a few numbers of adipokines with cardiovascular protective effects. Omentin has multiple cardiovascular benefits, such as anti-inflammatory, protecting endothelial,anti-oxidative stress, etc. At the same time, omentin shows beneficial effects on hypertension, diabetes, high blood lipids and other cardiovascular risk factors.

参考文献/References:

[1] Shibata R, Ouchi N, Kikuchi R,et al. Circulating omentin is associated with coronary artery disease in men[J].Atherosclerosis,2011,219(2):811-814. DOI: 10.1016/j.atherosclerosis.2011.08.017.
[2] Shang FJ, Wang JP, Liu XT,et al. Serum omentin-1 levels are inversely associated with the presence and severity of coronary artery disease in patients with metabolic syndrome[J].Biomarkers,2011,16(8):657-662. DOI: 10.3109/1354750X.2011.622789.
[3] Zhong X, Zhang HY, Tan H,et al. Association of serum omentin-1 levels with coronary artery disease[J].Acta Pharmacol Sin,2011,32(7):873-878. DOI: 10.1038/aps.2011.26.
[4] Onur I, Oz F, Yildiz S, et al. Serum omentin 1 level is associated with coronary artery disease and its severity in postmenopausal women[J].Angiology,2014,65(10):896-900. DOI: 10.1177/0003319713511322.
[5] Wang XH, Dou LZ, Gu C,et al. Plasma levels of omentin-1 and visfatin in senile patients with coronary heart disease and heart failure[J].Asian Pac J Trop Med,2014,7(1):55-62. DOI: 10.1016/S1995-7645(13)60192-3.
[6] Shibata R, Takahashi R, Kataoka Y, et al. Association of a fat-derived plasma protein omentin with carotid artery intima-media thickness in apparently healthy men[J]. Hypertens Res, 2011,34(12):1309-1312. DOI: 10.1038/hr.2011.130.
[7] Yoo HJ, Hwang SY, Hong HC,et al. Association of circulating omentin-1 level with arterial stiffness and carotid plaque in type 2 diabetes[J].Cardiovasc Diabetol, 2011,10:103.DOI: 10.1186/1475-2840-10-103.
[8] Liu R, Wang X, Bu P. Omentin-1 is associated with carotid atherosclerosis in patients with metabolic syndrome[J].Diabetes Res Clin Pract,2011,93(1):21-25. DOI: 10.1016/j.diabres.2011.03.001.
[9] Yoo HJ, Hwang SY, Hong HC,et al. Implication of circulating omentin-1 level on the arterial stiffening in type 2 diabetes mellitus[J]. Endocrine,2013,44(3):680-687. DOI: 10.1007/s12020-013-9930-1.
[10] Greulich S, Chen WJ, Maxhera B,et al. Cardioprotective properties of omentin-1 in type 2 diabetes: evidence from clinical and in vitro studies[J].PLoS One,2013,8(3):e59697.DOI: 10.1371/journal.pone.0059697.
[11] Wang XH, Dou LZ, Gu C, et al. Plasma levels of omentin-1 and visfatin in senile patients with coronary heart disease and heart failure[J].Asian Pac J Trop Med,2014,7(1):55-62.DOI: 10.1016/S1995-7645(13)60192-3.
[12] Miura S, Asano Y, Saigusa R,et al. Serum omentin levels: a possible contribution to vascular involvement in patients with systemic sclerosis[J].J Dermatol, 2015,42(5):461-466.DOI: 10.1111/1346-8138.12824.
[13] Kazama K, Okada M, Hara Y,et al. A novel adipocytokine, omentin, inhibits agonists-induced increases of blood pressure in rats[J].J Vet Med Sci,2013,75(8):1029-1034.
[14] Saremi A, Asghari M, Ghorbani A. Effects of aerobic training on serum omentin-1 and cardiometabolic risk factors in overweight and obese men[J].J Sports Sci, 2010,28(9):993-998. DOI: 10.1080/02640414.2010.484070.
[15] Wilms B, Ernst B, Gerig R,et al. Plasma omentin-1 levels are related to exercise performance in obese women and increase upon aerobic endurance training[J]. Exp Clin Endocrinol Diabetes,2015,123(3):187-192. DOI: 10.1055/s-0034-1398504.
[16] Zhang Q, Zhu L, Zheng M, et al. Changes of serum omentin-1 levels in normal subjects, type 2 diabetes and type 2 diabetes with overweight and obesity in Chinese adults[J].Ann Endocrinol(Paris),2014,75(3):171-175. DOI: 10.1016/j.ando.2014.04.013.
[17] Auguet T, Quintero Y, Riesco D,et al. New adipokines vaspin and omentin. Circulating levels and gene expression in adipose tissue from morbidly obese women[J].BMC Med Genet,2011,12:60. DOI: 10.1186/1471-2350-12-60.
[18] Bergmann K, Sypniewska G. Diabetes as a complication of adipose tissue dysfunction. Is there a role for potential new biomarkers?[J].Clin Chem Lab Med,2013,51(1):177-185. DOI: 10.1515/cclm-2012-0490.
[19] Yan P, Liu D, Long M,et al. Changes of serum omentin levels and relationship between omentin and adiponectin concentrations in type 2 diabetes mellitus[J].Exp Clin Endocrinol Diabetes,2011,119(4):257-263. DOI: 10.1055/s-0030-1269912.
[20] Aktas G, Alcelik A, Ozlu T,et al. Association between omentin levels and insulin resistance in pregnancy[J].Exp Clin Endocrinol Diabetes,2014,122(3):163-166. DOI: 10.1055/s-0034-1370917.
[21] Akbarzadeh S, Nabipour I, Assadi M,et al. The normoglycemic first-degree relatives of patients with type 2 diabetes mellitus have low circulating omentin-1 and adiponectin levels[J].Cytokine,2012,58(2):295-299. DOI: 10.1016/j.cyto.2012.02.005.
[22] Herder C, Ouwens DM, Carstensen M, et al. Adiponectin may mediate the association between omentin, circulating lipids and insulin sensitivity: results from the KORA F4 study[J].Eur J Endocrinol,2015,172(4):423-432. DOI: 10.1530/EJE-14-0879.
[23] El-Mesallamy HO, El-Derany MO, Hamdy NM. Serum omentin-1 and chemerin levels are interrelated in patients with type 2 diabetes mellitus with or without ischaemic heart disease[J].Diabet Med,2011,28(10):1194-1200. DOI: 10.1111/j.1464-5491.2011.03353.x.
[24] Kim HM, Lee BW, Song YM,et al. Potential association between coronary artery disease and the inflammatory biomarker YKL-40 in asymptomatic patients with type 2 diabetes mellitus[J]. Cardiovasc Diabetol,2012,11:84. DOI: 10.1186/1475-2840-11-84.
[25] Vu A, Sidhom MS, Bredbeck BC,et al. Evaluation of the relationship between circulating omentin-1 concentrations and components of the metabolicsyndrome in adults without type 2 diabetes or cardiovascular disease[J]. Diabetol Metab Syndr,2014,6(1):4. DOI: 10.1186/1758-5996-6-4.
[26] Urbanová M, Dostálová I, Trachta P, et al. Serum concentrations and subcutaneous adipose tissue mRNA expression of omentin in morbid obesity and type 2 diabetes mellitus: the effect of very-low-calorie diet, physical activity and laparoscopic sleeve gastrectomy[J]. Physiol Res,2014,63(2):207-218.
[27] Panagiotou G, Mu L, Na B, et al. Circulating irisin, omentin-1, and lipoprotein subparticles in adults at higher cardiovascular risk[J].Metabolism,2014,63(10):1265-1271. DOI: 10.1016/j.metabol.2014.06.001.
[28] Kazama K, Usui T, Okada M,et al. Omentin plays an anti-inflammatory role through inhibition of TNF-α-induced superoxide production in vascular smooth muscle cells[J].Eur J Pharmacol,2012,686(1-3):116-123. DOI: 10.1016/j.ejphar.2012.04.033.
[29] Yamawaki H, Kuramoto J, Kameshima S,et al. Omentin, a novel adipocytokine inhibits TNF-induced vascular inflammation in human endothelial cells[J].Biochem Biophys Res Commun,2011,408(2):339-343. DOI: 10.1016/j.bbrc.2011.04.039.
[30] Duan XY, Xie PL, Ma YL, et al. Omentin inhibits osteoblastic differentiation of calcifying vascular smooth muscle cells through the PI3K/Akt pathway[J].Amino Acids,2011,41(5):1223-1231. DOI: 10.1007/s00726-010-0800-3.
[31] Xie H, Xie PL, Wu XP,et al. Omentin-1 attenuates arterial calcification and bone loss in osteoprotegerin-deficient mice by inhibition of RANKL expression[J].Cardiovasc Res,201192(2):296-306. DOI: 10.1093/cvr/cvr200.
[32] Moreno-Navarrete JM, Ortega F, Castro A,et al. Circulating omentin as a novel biomarker of endothelial dysfunction[J].Obesity(Silver Spring),2011,19(8):1552-1559. DOI: 10.1038/oby.2010.351.
[33] Maruyama S, Shibata R, Kikuchi R, et al. Fat-derived factor omentin stimulates endothelial cell function and ischemia-induced revascularization via endothelial nitric oxide synthase-dependent mechanism[J].J Biol Chem,2012,287(1):408-417. DOI: 10.1074/jbc.M111.261818.
[34] Kazama K, Okada M, Yamawaki H. Adipocytokine, omentin inhibits doxorubicin-induced H9c2 cardiomyoblasts apoptosis through the inhibition of mitochondrial reactive oxygen species[J].Biochem Biophys Res Commun,2015,457(4):602-607. DOI: 10.1016/j.bbrc.2015.01.032.

相似文献/References:

[1]邵金双,邸阜生.网膜素抗炎作用及与代谢相关疾病的关系[J].国际内分泌代谢杂志,2014,(01):29.[doi:10.3760/cma.j.issn.1673-4157.2014.01.008]
 Shao Jinshuang*,Di Fusheng ..Anti-inflammatory effect of omentin and its relationship with metabolic diseases[J].International Journal of Endocrinology and Metabolism,2014,(04):29.[doi:10.3760/cma.j.issn.1673-4157.2014.01.008]
[2]张琳,费雯婕,宋光耀.网膜素与代谢综合征[J].国际内分泌代谢杂志,2016,36(01):42.[doi:10.3760/cma.j.issn.1673-4157.2016.01.010]
 Zhang Lin*,Fei Wenjie,Song Guangyao..Omentin and metabolic syndrome[J].International Journal of Endocrinology and Metabolism,2016,36(04):42.[doi:10.3760/cma.j.issn.1673-4157.2016.01.010]
[3]郑辉 常宝成 葛焕琦.3'-碘甲状腺原氨酸:保护心脏和调节代谢的新武器[J].国际内分泌代谢杂志,2019,39(02):140.[doi:10.3760/cma.j.issn.1673-4157.2019.02.013]
 Zheng Hui,Chang Baocheng,Ge Huanqi.3'-Iodothyronamine: a new weapon to protect the heart and regulate metabolism[J].International Journal of Endocrinology and Metabolism,2019,39(04):140.[doi:10.3760/cma.j.issn.1673-4157.2019.02.013]

备注/Memo

备注/Memo:
通信作者:葛焕琦,Email:gehuanqi@163.com
更新日期/Last Update: 2016-09-20