[1]胡雯婧,朱惠娟,龚凤英.成纤维细胞生长因子21治疗肥胖症及其相关代谢性疾病的研究进展[J].国际内分泌代谢杂志,2023,43(02):117-120.[doi:10.3760/cma.j.cn121383-20220125-01048]
 Hu Wenjing,Zhu Huijuan,Gong Fengying..Research progress of fibroblast growth factor 21 in the treatment of obesity and its associated metabolic diseases[J].International Journal of Endocrinology and Metabolism,2023,43(02):117-120.[doi:10.3760/cma.j.cn121383-20220125-01048]
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成纤维细胞生长因子21治疗肥胖症及其相关代谢性疾病的研究进展()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
43
期数:
2023年02期
页码:
117-120
栏目:
综述
出版日期:
2023-03-20

文章信息/Info

Title:
Research progress of fibroblast growth factor 21 in the treatment of obesity and its associated metabolic diseases
作者:
胡雯婧朱惠娟龚凤英
中国医学科学院 北京协和医学院 北京协和医院内分泌科 国家卫生健康委员会内分泌重点实验室 协和转化医学中心,北京 100730
Author(s):
Hu Wenjing Zhu Huijuan Gong Fengying.
Department of Endocrinology, Key Laboratory of Endocrinology of National Health Commission, the Translational Medicine Center of PUMCH, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China
关键词:
成纤维细胞生长因子21 肥胖症 糖脂代谢 人成纤维细胞生长因子21类似物 成纤维细胞生长因子21受体激动剂
Keywords:
Fibroblast growth factor 21 Obesity Glucolipid metabolism Human fibroblast growth factor 21 analogue Fibroblast growth factor 21 receptor agonist
DOI:
10.3760/cma.j.cn121383-20220125-01048
摘要:
成纤维细胞生长因子(FGF)21是一类新近发现的代谢调节因子,主要由肝脏分泌,与靶组织的FGF受体(FGFR)及共受体β-klotho形成的受体复合物结合,发挥减重、降血糖、改善脂代谢以及减少组织炎性反应等作用。实验证实,外源性给予FGF21能够通过诱导能量消耗、促进脂肪分解、减少脂质合成、促进白色脂肪组织棕色化、增加脂联素水平和改善瘦素抵抗等发挥减重、改善糖脂代谢、保护胰岛和心肌细胞的作用。目前,基于FGF21的药物研发成为当前的研究热点,主要包括人FGF21类似物和FGF21受体激动剂两种,已在动物和人体试验中应用于改善肥胖症及非酒精性脂肪性肝炎、糖尿病等代谢异常相关疾病,有望成为治疗这些疾病的新药。
Abstract:
Fibroblast growth factor 21(FGF21)is a newly discovered metabolic regulator. It is mainly secreted by the liver and cooperates with the receptor complex composed by FGF receptor(FGFR)and β- Klotho co-receptor in target tissue. It can reduce weight, decrease blood sugar, improve lipid metabolism and lessen tissue inflammation. Exogenous administration of FGF21 plays the role of reducing weight, improving glucolipid metabolism and protecting pancreatic islet and myocardial cells by enhancing energy consumption, promoting lipolysis, inhibiting lipogenesis, increasing browning of white adipose tissue, raising adiponectin and improving leptin resistance. At present, the research of drugs based on FGF21 has become a current hot spot, which mainly include human FGF21 analogues and FGF21 receptor agonists. They have been applied in animals and human's trials to improve obesity and related metabolic abnormalities such as nonalcoholic steatohepatitis and diabetes. They are expected to become new drugs for the treatment of these diseases.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金(822709136); 中国医学科学院医学与健康科技创新工程项目(2022-I2M-2-002); 北京市自然科学基金(7222137); 国家临床重点专科能力提升项目(U110000)
通信作者:龚凤英,Email: fygong@sina.com
更新日期/Last Update: 2023-04-15