[1]付友娟 乐岭.脂毒性诱导甲状腺功能减退的机制研究进展[J].国际内分泌代谢杂志,2022,42(04):284-287.[doi:10.3760/cma.j.cn121383-20210903-09007]
　Fu Youjuan,Yue Ling..Research progress of the mechanisms of lipotoxicity-induced hypothyroidism[J].International Journal of Endocrinology and Metabolism,2022,42(04):284-287.[doi:10.3760/cma.j.cn121383-20210903-09007]
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脂毒性诱导甲状腺功能减退的机制研究进展()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
42
期数:
2022年04期
页码:
284-287
栏目:
临床研究
出版日期:
2022-07-20

文章信息/Info

Title:
Research progress of the mechanisms of lipotoxicity-induced hypothyroidism
作者:
付友娟1; 2 乐岭1; 2
1武汉科技大学医学院 430065; 2中国人民解放军中部战区总医院内分泌科,武汉 430070
Author(s):
Fu Youjuan1; 2;  Yue Ling1; 2.
1Wuhan University of Science and Technology School of Medicine, Wuhan 430065, China; 2Department of Endocrinology, General Hospital of Central Theater Command of the Chinese People's Liberation Army, Wuhan 430070, China
关键词:
脂毒性;  甲状腺功能减退;  内质网应激;  赖氨酸琥珀酰化
Keywords:
Lipotoxicity;  Hypothyroidism;  Endoplasmic reticulum stress;  Lysine succinylation
DOI:
10.3760/cma.j.cn121383-20210903-09007
摘要:
脂毒性与甲状腺功能减退(甲减)有着密切联系,脂毒性诱导甲减的机制尚处于探索阶段。目前的研究发现,炎性因子可下调甲状腺滤泡上皮细胞碘摄取及激素合成; 组织中脱碘酶的表达和活性变化可影响T4的转化; 氧化应激过度激活可损伤甲状腺滤泡上皮细胞特异性蛋白表达。此外,赖氨酸琥珀酰化修饰异常及内质网应激(ERS)激活在脂毒性诱导甲状腺功能损伤中的作用成为研究热点。对脂毒性诱导甲减的机制进行深入研究将为脂毒性致全身损伤提供理论依据。
Abstract:
Lipotoxicity is closely related to hypothyroidism, while the mechanisms of lipotoxicity-induced hypothyroidism are still in the initial stage of exploration. The current studies suggest inflammatory factors can down-regulate iodine uptake and hormone synthesis in thyroid follicular epithelial cells, changes in the expression and activity of deiodinase in tissues can affect the transformation of T4, and excessive activation of oxidative stress may damage the specific protein expression of thyroid follicular epithelial cells. Moreover, the role of abnormal lysine succinylation modification and endoplasmic reticulum stress(ERS)activation in lipotoxicity-induced thyroid dysfunction has become the focus of researches. Further study of the mechanisms of lipotoxicity-induced hypothyroidism will provide a theoretical basis for systemic damage caused by lipotoxicity.

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备注/Memo

备注/Memo:
基金项目:中华医学会中华国际交流基金会“国际糖尿病交流与实践专项基金”(Z-2017-26-1902)
通信作者:乐岭,Email:yuelingwh@163.com
更新日期/Last Update: 2022-06-20