[1]赵耕 牛文彦.中性粒细胞明胶酶相关脂质运载蛋白在代谢相关肾损伤中的应用价值分析[J].国际内分泌代谢杂志,2022,42(04):272-275.[doi:10.3760/cma.j.cn121383-20210928-09084]
　Zhao Geng,Niu Wenyan..Application value of neutrophil gelatinase related lipid carrier protein in metabolism related renal injury[J].International Journal of Endocrinology and Metabolism,2022,42(04):272-275.[doi:10.3760/cma.j.cn121383-20210928-09084]
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中性粒细胞明胶酶相关脂质运载蛋白在代谢相关肾损伤中的应用价值分析()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
42
期数:
2022年04期
页码:
272-275
栏目:
临床研究
出版日期:
2022-07-20

文章信息/Info

Title:
Application value of neutrophil gelatinase related lipid carrier protein in metabolism related renal injury
作者:
赵耕1; 2 牛文彦1
1天津医科大学朱宪彝纪念医院、天津市内分泌研究所、国家卫生健康委员会激素与发育重点实验室、天津市代谢性疾病重点实验室,检验科 300134; 2西藏自治区昌都市藏医院检验科 854000
Author(s):
Zhao Geng1; 2;  Niu Wenyan1.
1Department of Laboratory, NHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory of Metabolic Diseases, Chu Hsien-I Memorial Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin 300134, China; 2Department of Laboratory, Tibet Autonomous Region Changdu Tibetan Hospital, Changdu 854000, China
关键词:
中性粒细胞明胶酶相关脂质运载蛋白;  糖尿病肾脏病;  高尿酸;  肥胖;  肾损伤
Keywords:
Neutrophil gelatinase-associated lipid carrier protein;  Diabetic kidney disease;  High uric acid;  Obesity;  Kidney injury
DOI:
10.3760/cma.j.cn121383-20210928-09084
摘要:
中性粒细胞明胶酶相关脂质运载蛋白(neutrophil gelatinase-associated lipocalin,NGAL)作为一类新发现的脂肪细胞因子,广泛存在于机体发生代谢异常时的病变组织细胞内。大量动物及临床试验证实,NGAL可在肝脏、肾脏、心脏、胰腺、前列腺及上皮细胞等多种组织中微表达,在肥胖-炎症-代谢综合征及其引起的胰岛素抵抗、各种慢性肾病、心脑血管疾病、炎性反应及肿瘤等疾病中参与机体生理病理过程,本文主要针对NGAL与代谢相关肾损伤的关系进行综述,为临床的预防、早期诊断和治疗提供依据。
Abstract:
Neutrophil gelati-nase associated lipocalin(NGAL), as a newly discovered adipocytokines, widely exists in the cells of diseased tissues when metabolic abnormalities occur. A large number of animal and clinical trials have confirmed that NGAL can be expressed in trace amounts in various tissues such as liver, kidney, heart, pancreas, prostate and epithelial cells, and participate in the physiological and pathological process of obesity inflammation metabolism syndrome and its induced insulin resistance, various chronic kidney diseases, cardiovascular and cerebrovascular diseases, inflammatory response and tumors. This article mainly reviews the association between NGAL and metabolism related kidney injury, so as to provide basis for clinical prevention, early diagnosis and treatment.

参考文献/References:

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备注/Memo

备注/Memo:
基金项目:西藏自治区自然科学基金项目(XZ2019ZRG-143)
通信作者:赵耕,Email: 13212156976@163.com
更新日期/Last Update: 2022-06-20