[1]徐昳文,周红文.妊娠期葡萄糖激酶基因突变导致的青少年发病的成人型糖尿病研究进展[J].国际内分泌代谢杂志,2021,41(05):418-421.[doi:10.3760/cma.j.cn121383-20210603-06005]
 Xu Yiwen,Zhou Hongwen..Recent progress in glucokinase-maturity-onset diabetes of the young in pregnancy[J].International Journal of Endocrinology and Metabolism,2021,41(05):418-421.[doi:10.3760/cma.j.cn121383-20210603-06005]
点击复制

妊娠期葡萄糖激酶基因突变导致的青少年发病的成人型糖尿病研究进展()
分享到:

《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
41
期数:
2021年05期
页码:
418-421
栏目:
“特殊类型糖尿病”专题
出版日期:
2021-09-30

文章信息/Info

Title:
Recent progress in glucokinase-maturity-onset diabetes of the young in pregnancy
作者:
徐昳文周红文
南京医科大学第一附属医院内分泌科 210029
Author(s):
Xu Yiwen Zhou Hongwen.
Department of Endocrinology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
关键词:
青少年发病的成人型糖尿病 妊娠糖尿病 葡萄糖激酶
Keywords:
Maturity-onset diabetes of the young Gestational diabetes mellitus Glucokinase
DOI:
10.3760/cma.j.cn121383-20210603-06005
摘要:
青少年发病的成人型糖尿病(MODY)是呈常染色体显性遗传的一种特殊类型糖尿病,因其表型与1型糖尿病和2型糖尿病相重叠,故常被误诊。其中,最常见的类型之一是MODY2,它是由葡萄糖激酶(GCK)基因突变引起的,因此被称为GCK-MODY。GCK-MODY患者的微血管和大血管并发症较少见,故普遍认为在非妊娠期不需要治疗。虽然针对GCK-MODY的诊疗策略已逐渐建立,但GCK-MODY患者孕期血糖的控制及胎儿的突变状态可能会影响妊娠结局,因此妊娠期GCK-MODY的治疗管理十分重要,值得探索。
Abstract:
Maturity-onset diabetes of the young(MODY)is a cluster of monogenic diabetes classified in specific types of diabetes, inherited in an autosomal dominant manner. MODY is often underdiagnosed or misdiagnosed with type 1 or type 2 diabetes. MODY2, also known as GCK-MODY, is caused by disease-causing mutations in glucokinase, which usually characterized by mild hyperglycemia, low risks for macrovascular and microvascular complications, thus barely treated or even not recommended for treatment in females outside of pregnancy. However, many more considerations should be taken regarding GCK-MODY in pregnancy. Different combinations of genotype in GCK of both moms and infants make it even complex when reaching ideal blood glucose control and normal infant development. Therefore, the treatment and management of GCK-MODY in pregnancy is very important and worth exploring.

参考文献/References:

[1] Peixoto-Barbosa R,Reis AF,Giuffrida FMA.Update on clinical screening of maturity-onset diabetes of the young(MODY)[J].Diabetol Metab Syndr,2020,12:50.DOI:10.1186/s13098-020-00557-9.
[2] Urakami T.Maturity-onset diabetes of the young(MODY):current perspectives on diagnosis and treatment[J].Diabetes Metab Syndr Obes,2019,12:1047-1056.DOI:10.2147/DMSO.S179793.
[3] Dickens LT,Naylor RN.Clinical management of women with monogenic diabetes during pregnancy [J].Curr Diab Rep,2018,18(3):12.DOI:10.1007/s11892-018-0982-8.
[4] 周媛,王胜楠,廖琳.青少年发病的成年型糖尿病2型(MODY2)的诊疗进展[J].中国实验诊断学,2020,24(2):364-367.DOI:10.3969/j.issn.1007-4287.2020.02.054.
[5] Ma Y,Han X,Zhou X,et al.A new clinical screening strategy and prevalence estimation for glucokinase variant-induced diabetes in an adult Chinese population [J].Geneti Med,2019,21(4):939-947.DOI:10.1038/s41436-018-0282-3.
[6] 胡玉玺,陈永收,任一鑫,等.治疗2型糖尿病的在研新药——葡萄糖激酶激动剂HMS5552 [J].临床药物治疗杂志,2020,18(6):1-5.DOI:10.3969/j.issn.1672-3384.2020.06.001.
[7] Chakera AJ,Spyer G,Vincent N,et al.The 0.1% of the population with glucokinase monogenic diabetes can be recognized by clinical characteristics in pregnancy:the Atlantic Diabetes in Pregnancy cohort [J].Diabetes Care,2014,37(5):1230-1236.DOI:10.2337/dc13-2248.
[8] Kleinberger JW,Maloney KA,Pollin TI.The genetic architecture of diabetes in pregnancy:implications for clinical practice[J].Am J Perinatol,2016,33(13):1319-1326.DOI:10.1055/s-0036-1592078.
[9] Rudland VL,Hinchcliffe M,Pinner J,et al.Identifying glucokinase monogenic diabetes in a multiethnic gestational diabetes mellitus cohort:New Pregnancy Screening Criteria and Utility of HbAlc [J].Diabetes Care,2016,39(1):50-52.DOI:10.2337/dc15-1001.
[10] Bhargava A,Siddiqui S,Waghdhare S,et al.Comment on Rudland et al.Identifying glucokinase monogenic diabetes in a multiethnic gestational diabetes mellitus cohort:new pregnancy screening criteria and utility of HbA1c.Diabetes Care,2016; 39:50-52[J].Diabetes Care,2016,39(1):e6.DOI:10.2337/dc15-1537.
[11] Kopacz-Petranyuk K,Brandt-Varma A,Buraczewska M,et al.Neonatal outcome and diabetes course in children with GCK-MODY born from women with GCK-MODY[J].Pediatr Endocrinol Diabetes Metab,2018,24(4):167-173.DOI:10.5114/pedm.2018.83362.
[12] Monsonego S,Clark H,Karovitch A,et al.Management and outcomes of Maturity-Onset Diabetes of the young in pregnancy[J].Can J Diabetes,2019,43(8):647-654.DOI:10.1016/j.jcjd.2019.07.004.
[13] Hosokawa Y,Higuchi S,Kawakita R,et al.Pregnancy outcome of Japanese patients with glucokinase-maturity-onset diabetes of the young[J].J Diabetes Investig,2019,10(6):1586-1589.DOI:10.1111/jdi.13046
[14] López Tinoco C,Sánchez Lechuga B,Bacon S,et al.Evaluation of pregnancy outcomes in women with GCK-MODY[J].Diabet Med,2021,38(6):e14488.DOI:10.1111/dme.14488.
[15] Spyer G,Macleod KM,Shepherd M,et al.Pregnancy outcome in patients with raised blood glucose due to a heterozygous glucokinase gene mutation[J].Diabet Med,2009,26(1):14-18.DOI:10.1111/j.1464-5491.2008.02622.x.
[16] Bitterman O,Tinto N,Franzese A,et al.Glucokinase deficit and birthweight:does maternal hyperglycemia always meet fetal needs? [J].Acta Diabetol,2018,55(12):1247-1250.DOI:10.1007/s00592-018-1198-8.
[17] Bacon S,Schmid J,McCarthy A,et al.The clinical management of hyperglycemia in pregnancy complicated by maturity-onset diabetes of the young[J].Am J Obstet Gynecol,2015,213(2):236.e1-7.DOI:10.1016/j.ajog.2015.04.037.
[18] Bianchi DW,Chiu RWK.Sequencing of circulating cell-free DNA during pregnancy[J]. N Engl J Med,2018,379(5):464-473.DOI:10.1056/NEJMra1705345.
[19] Alejandro EU,Mamerto TP,Chung G,et al.Gestational diabetes mellitus:a harbinger of the vicious cycle of diabetes[J].Int J Mol Sci,2020,21(14):5003.DOI:10.3390/ijms21145003.
[20] Chen C,Xu X,Yan Y.Estimated global overweight and obesity burden in pregnant women based on panel data model[J]. PLoS One,2018,13(8):e0202183.DOI:10.1371/journal.pone.0202183.
[21] Rudland VL.Diagnosis and management of glucokinase monogenic diabetes in pregnancy:current perspectives[J].Diabetes Metab Syndr Obes,2019,12:1081-1089.DOI:10.2147/DMSO.S186610.
[22] Dickens LT,Letourneau LR,Sanyoura M,et al.Management and pregnancy outcomes of women with GCK-MODY enrolled in the US Monogenic Diabetes Registry[J].Acta Diabetol,2019,56(4):405-411.DOI:10.1007/s00592-018-1267-z.

相似文献/References:

[1]林戎,沈忱,黄昭穗.瘦素与妊娠糖尿病患者胰岛素抵抗及胎儿 发育的相关性[J].国际内分泌代谢杂志,2017,37(06):367.
 Lin Rong,Shen Chen,Huang Zhaosui..Relationship between leptin and insulin resistance, fetal growth and development in patients with gestational diabetes mellitus[J].International Journal of Endocrinology and Metabolism,2017,37(05):367.
[2]吴一鸣 杨震 秦利.细胞因子与妊娠糖尿病的关系[J].国际内分泌代谢杂志,2018,38(01):59.[doi:10.3760/cma.j.issn.1673-4157.2018.01.016]
 Wu Yiming,Yang Zhen,Qin Li.Relationship between cytokines and gestational diabetes mellitus[J].International Journal of Endocrinology and Metabolism,2018,38(05):59.[doi:10.3760/cma.j.issn.1673-4157.2018.01.016]
[3]周晓聪 张晓黎.益生菌与妊娠糖尿病的相关性[J].国际内分泌代谢杂志,2018,38(05):313.[doi:10.3760/cma.j.issn.1673-4157.2018.05.007]
 Zhou Xiaocong,Zhang Xiaoli.Relationship between probiotics and gestational diabetes mellitus[J].International Journal of Endocrinology and Metabolism,2018,38(05):313.[doi:10.3760/cma.j.issn.1673-4157.2018.05.007]
[4]孙树凯 翟玉娥 田清武 赵鹏 申井利 翟木绪.雌激素受体基因多态性与妊娠糖尿病的 相关性研究[J].国际内分泌代谢杂志,2018,38(06):361.[doi:10.3760/cma.j.issn.1673-4157.2018.06.001]
 Sun Shukai*,Zhai Yu'e,Tian Qingwu,et al.Correlation between polymorphism of estrogen receptor gene and gestational diabetes mellitus[J].International Journal of Endocrinology and Metabolism,2018,38(05):361.[doi:10.3760/cma.j.issn.1673-4157.2018.06.001]
[5]王香青 马振军 孔方方.外泌体与妊娠糖尿病[J].国际内分泌代谢杂志,2019,39(03):194.[doi:10.3760/cma.j.issn.1673-4157.2019.03.012]
 Wang Xiangqing,Ma Zhenjun,Kong Fangfang.Exosomes and gestational diabetes mellitus[J].International Journal of Endocrinology and Metabolism,2019,39(05):194.[doi:10.3760/cma.j.issn.1673-4157.2019.03.012]
[6]郑妙艳 石文琦 张美琳 单春艳.microRNA作为妊娠糖尿病标志物的研究进展[J].国际内分泌代谢杂志,2019,39(04):272.[doi:10.3760/cma.j.issn.1673-4157.2019.04.014]
 Zheng Miaoyan,Shi Wenqi,Zhang Meilin,et al.Perspectives in microRNA as biomarkers of gestational diabetes mellitus[J].International Journal of Endocrinology and Metabolism,2019,39(05):272.[doi:10.3760/cma.j.issn.1673-4157.2019.04.014]
[7]苏亚峰 相萍萍 陈国芳 刘超.低升糖指数饮食与糖尿病血糖及血脂控制的关系[J].国际内分泌代谢杂志,2020,40(01):31.[doi:10.3760/cma.j.issn.1673-4157.2020.01.007]
 Su Yafeng,Xiang Pingping,Chen Guofang,et al.Relationship between low glycemic index diet and blood glucose, blood lipid control in diabetes mellitus[J].International Journal of Endocrinology and Metabolism,2020,40(05):31.[doi:10.3760/cma.j.issn.1673-4157.2020.01.007]
[8]欧杨,周怡昆.青少年发病的成人型糖尿病的妊娠期管理[J].国际内分泌代谢杂志,2021,41(05):422.[doi:10.3760/cma.j.cn121383-20210622-06062]
 Ou Yang,Zhou Yikun..Gestational management of maturity-onset diabetes of the young[J].International Journal of Endocrinology and Metabolism,2021,41(05):422.[doi:10.3760/cma.j.cn121383-20210622-06062]

备注/Memo

备注/Memo:
通信作者:周红文,Email:drhongwenzhou@njmu.edu.cn
更新日期/Last Update: 2021-10-10