[1]张越,周波.巨大囊性嗜铬细胞瘤/副神经节瘤诊治研究进展[J].国际内分泌代谢杂志,2021,41(03):212-215.[doi:10.3760/cma.j.cn121383-20200922-09042]
　Zhang Yue,Zhou Bo..Research progress on diagnosis and treatment of giant cystic pheochromocytoma/paraganglioma[J].International Journal of Endocrinology and Metabolism,2021,41(03):212-215.[doi:10.3760/cma.j.cn121383-20200922-09042]
点击复制

巨大囊性嗜铬细胞瘤/副神经节瘤诊治研究进展()
分享到：

《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
41
期数:
2021年03期
页码:
212-215
栏目:
综述
出版日期:
2021-05-20

文章信息/Info

Title:
Research progress on diagnosis and treatment of giant cystic pheochromocytoma/paraganglioma
作者:
张越; 周波
重庆医科大学附属第一医院内分泌科 400016
Author(s):
Zhang Yue;  Zhou Bo.
Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
关键词:
嗜铬细胞瘤;  副神经节瘤;  囊肿;  诊治
Keywords:
Pheochromocytoma;  Paraganglioma;  Cyst;  Diagnosis and treatment
DOI:
10.3760/cma.j.cn121383-20200922-09042
摘要:
嗜铬细胞瘤并不常见,而巨大囊性嗜铬细胞瘤更为少见,是嗜铬细胞瘤的一个亚组,大部分因为肿瘤坏死和出血过程形成囊性,极少为真囊肿。因为大部分儿茶酚胺在肿瘤内代谢或储存,当肿瘤发生囊性退变时,儿茶酚胺生成减少或储存在胞膜下,不易释放入血,导致其缺乏典型嗜铬细胞瘤的常见症状,生化检查儿茶酚胺代谢产物阴性亦不少见,加之影像学表现多样,不易与其他腹腔或腹膜后占位鉴别,早期诊断极困难。本文就巨大囊性嗜铬细胞瘤的发生机制、临床表现、诊治等方面综述其进展,以加深对本病的认识,提高临床诊断的准确率。
Abstract:
Pheochromocytoma is not common, while giant cystic pheochromocytoma is even more rare. It is a subgroup of pheochromocytoma. Most of them are cystic due to tumor necrosis and hemorrhagic process, and rarely are true cysts. Because most of the catecholamines are metabolized or stored in the tumor, when the tumor undergoes cystic degeneration, the production of catecholamines is reduced or stored under the cell membrane, which is not easy to release into the blood, resulting in a lack of common symptoms of typical pheochromocytoma. Biochemical examination of catecholamines metabolites is more likely to be negative. In addition to the diverse imaging findings, it is not easy to differentiate from other abdominal or retroperitoneal space, and early diagnosis is extremely difficult. This article reviews the progress of giant cystic pheochromocytoma in terms of its mechanism, clinical manifestations, diagnosis and treatment, in order to deepen the understanding of the disease and improve the accuracy of clinical diagnosis.

参考文献/References:

[1] Fu SQ,Zhuang CS,Yang XR,et al.Comparison of robot-assisted retroperitoneal laparoscopic adrenalectomy versus retroperitoneal laparoscopic adrenalectomy for large pheochromocytoma:a single-centre retrospective study[J].BMC Surg,2020,20(1):227.DOI:10.1186/s12893-020-00895-5.
[2] Ito Y,Obara T,Yamashita T,et al.Pheochromocytomas:tendency to degenerate and cause paroxysmal hypertension[J].World J Surg,1996,20(7):923-927.DOI:10.1007/s002689900140.
[3] Yamada Y,Fujiwara H,Banno H,et al.Complete atrioventricular dissociation and sinus arrest after pheochromocytoma resection[J].IJU Case Rep,2020,3(3):108-111.DOI:10.1002/iju5.12160.
[4] Tevosian SG,Ghayee HK.Pheochromocytomas and paragangliomas[J].Endocrinol Metab Clin North Am,2019,48(4):727-750.DOI:10.1016/j.ecl.2019.08.006.
[5] Mercado-Asis LB,Wolf KI,Jochmanova I,et al.Pheochromocytoma:a genetic and diagnostic update[J].Endocr Pract,2018,24(1):78-90.DOI:10.4158/EP-2017-0057.
[6] Farrugia FA,Charalampopoulos A.Pheochromocytoma[J].Endocr Regul,2019,53(3):191-212.DOI:10.2478/enr-2019-0020.
[7] Andreoni C,Krebs RK,Bruna PC,et al.Cystic phaeochromocytoma is a distinctive subgroup with special clinical,imaging and histological features that might mislead the diagnosis[J].BJU Int,2008,101(3):345-350.DOI:10.1111/j.1464-410X.2007.07370.x.
[8] Pogorzelski R,Toutounchi S,Krajewska E,et al.Adrenal cysts - optimal laparoscopic treatment[J].Wideochir Inne Tech Maloinwazyjne,2018,13(3):288-291.DOI:10.5114/wiitm.2018.75872.
[9] Carsote M,Ghemigian A,Terzea D,et al.Cystic adrenal lesions:focus on pediatric population(a review)[J].Clujul Med,2017,90(1):5-12.DOI:10.15386/cjmed-677.
[10] Chakraborty PP,Patra S,Biswas SN,et al.Pure cystic adrenal space-occupying lesion:always rule out cystic pheochromocytoma[J].BMJ Case Rep,2016,2016:bcr2016216337.DOI:10.1136/bcr-2016-216337.
[11] Pan D,Liang P,Xiao H.Neurofibromatosis type 1 associated with pheochromocytoma and gastrointestinal stromal tumors:a case report and literature review[J].Oncol Lett,2016,12(1):637-643.DOI:10.3892/ol.2016.4670.
[12] 罗琼,陈小军.囊性异位嗜铬细胞瘤一例[J].临床放射学杂志,2018,37(6):1066-1067.DOI:10.13437/j.cnki.jcr.2018.06.049.
[13] Clements HA,Wilson MS,Smith DM.Incidental giant cystic pheochromocytoma:a case report and review of the literature[J].Scott Med J,2020,65(2):64-70.DOI:10.1177/0036933019900339.
[14] Nölting S,Ullrich M,Pietzsch J,et al.Current management of pheochromocytoma/paraganglioma:a guide for the practicing clinician in the era of precision medicine[J].Cancers(Basel),2019,11(10):1505.DOI:10.3390/cancers11101505.
[15] Sarveswaran V,Kumar S,Kumar A,et al.A giant cystic pheochromocytoma mimicking liver abscess an unusual presentation - a case report[J].Clin Case Rep,2015,3(1):64-68.DOI:10.1002/ccr3.149.
[16] Gupta A,Bains L,Agarwal MK,et al.Giant cystic pheochromocytoma:a silent entity[J].Urol Ann,2016,8(3):384-386.DOI:10.4103/0974-7796.184886.
[17] Hoegerle S,Nitzsche E,Altehoefer C,et al.Pheochromocytomas:detection with 18F DOPA whole body PET--initial results[J].Radiology,2002,222(2):507-512.DOI:10.1148/radiol.2222010622.
[18] 王芬,童安莉,曾正陪.恶性嗜铬细胞瘤/副神经节瘤的治疗[J].国际内分泌代谢杂志,2016,36(3):187-190.DOI:10.3760/cma.j.issn.1673-4157.2016.03.11.
[19] Park J,Song C,Park M,et al.Predictive characteristics of malignant pheochromocytoma[J].Korean J Urol,2011,52(4):241-246.DOI:10.4111/kju.2011.52.4.241.
[20] Rijken JA,Niemeijer ND,Jonker MA,et al.The penetrance of paraganglioma and pheochromocytoma in SDHB germline mutation carriers[J].Clin Genet,2018,93(1):60-66.DOI:10.1111/cge.13055.
[21] Stenman A,Svahn F,Hojjat-Farsangi M,et al.Molecular profiling of pheochromocytoma and abdominal paraganglioma stratified by the PASS algorithm reveals chromogranin B as associated with histologic prediction of malignant behavior[J].Am J Surg Pathol,2019,43(3):409-421.DOI:10.1097/PAS.0000000000001190.
[22] 赵磊,梁朝朝.嗜铬细胞瘤的诊断及治疗进展[J].现代泌尿生殖肿瘤杂志,2019,11(3):181-183.DOI:10.3870/j.issn.167424.2019.03.016.
[23] Fermandois M,Altamirano J,Rojas F,et al.Manejo perioperatorio de feocromocitomay paraganglioma[Perioperative management of paragangliomas and pheochromocytomas][J].Medwave,2020,20(2):e7830.DOI:10.5867/medwave.2020.02.7830.
[24] Bittner JG 4th,Gershuni VM,Matthews BD,et al.Risk factors affecting operative approach,conversion,and morbidity for adrenalectomy:a single-institution series of 402 patients[J].Surg Endosc,2013,27(7):2342-2350.DOI:10.1007/s00464-013-2789-7.
[25] Zhu W,Wang S,Du G,et al.Comparison of retroperitoneal laparoscopic versus open adrenalectomy for large pheochromocytoma:a single-center retrospective study[J].World J Surg Oncol,2019,17(1):111.DOI:10.1186/s12957-019-1649-x.
[26] Samejima M,Taguchi S,Miyagawa S,et al.Acute hypotension induced by suction of cystic fluid containing extremely high concentrations of catecholamines during resection of giant pheochromocytoma[J].IJU Case Rep,2019,2(4):218-220.DOI:10.1002/iju5.12087.
[27] Hamidi O,Young WF Jr,Iñiguez-Ariza NM,et al.Malignant pheochromocytoma and paraganglioma:272 patients over 55 years[J].J Clin Endocrinol Metab,2017,102(9):3296-3305.DOI:10.1210/jc.2017-00992.

相似文献/References:

[1]马晓森,童安莉.嗜铬细胞瘤分子病因学研究进展[J].国际内分泌代谢杂志,2021,41(02):82.[doi:10.3760/cma.j.cn121383-20200630-06087]
　Ma Xiaosen,Tong Anli..Research progress on the molecular etiology of pheochromocytoma[J].International Journal of Endocrinology and Metabolism,2021,41(03):82.[doi:10.3760/cma.j.cn121383-20200630-06087]
[2]刘鹭,高莹,张俊清,等.甲氧基肾上腺素类物质、3-甲氧酪胺及嗜铬粒蛋白A在PPGL诊断中的作用[J].国际内分泌代谢杂志,2021,41(02):96.[doi:10.3760/cma.j.cn12383-20200522-05070]
　Liu Lu,Gao Ying,Zhang Junqing,et al.Role of metanephrines, 3-methoxytyramine and chromogranin A in the diagnosis of PPGL[J].International Journal of Endocrinology and Metabolism,2021,41(03):96.[doi:10.3760/cma.j.cn12383-20200522-05070]
[3]刘海春 高洪波 李赟 李隆敏 邵玉军.基因突变对嗜铬细胞瘤/副神经节瘤临床特征及预后的影响[J].国际内分泌代谢杂志,2023,43(05):392.[doi:10.3760/cma.j.cn121383-20221029-10044]
　Liu Haichun,Gao Hongbo,Li Yun,et al.Effect of gene mutations on clinical features and prognosis of pheochromocytoma/paraganglioma[J].International Journal of Endocrinology and Metabolism,2023,43(03):392.[doi:10.3760/cma.j.cn121383-20221029-10044]

备注/Memo

备注/Memo:
通信作者:周波,Email:zhoubo915@126.com
更新日期/Last Update: 2021-05-20