[1]申奥 赵艳艳.尿外泌体与糖尿病肾脏疾病[J].国际内分泌代谢杂志,2019,39(06):391-393.[doi:10.3760/cma.j.issn.1673-4157.2019.06.007]
　Shen Ao,Zhao Yanyan.Urinary exosomes and diabetic kidney disease[J].International Journal of Endocrinology and Metabolism,2019,39(06):391-393.[doi:10.3760/cma.j.issn.1673-4157.2019.06.007]
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尿外泌体与糖尿病肾脏疾病()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
39
期数:
2019年06期
页码:
391-393
栏目:
综述
出版日期:
2019-11-20

文章信息/Info

Title:
Urinary exosomes and diabetic kidney disease
作者:
申奥 赵艳艳
郑州大学第一附属医院内分泌科 450052
Author(s):
Shen Ao;  Zhao Yanyan
Department of Endocrinology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
关键词:
尿外泌体;  糖尿病肾脏疾病;  生物标志物
Keywords:
Urine exosomes;  Diabetic kidney disease;  Biomarker
DOI:
10.3760/cma.j.issn.1673-4157.2019.06.007
摘要:
糖尿病肾脏疾病(DKD)已经成为导致终末期肾病的主要原因之一。尿外泌体内含有来自肾单位所有细胞的蛋白质以及成千上万种RNA、miRNA,这些物质随着尿外泌体在肾脏细胞之间转移,改变细胞的蛋白质组成和功能,并且影响肾脏细胞间的信号转导,参与DKD的发病机制。因此,尿外泌体及其所含的丰富的生物信息可能是DKD非侵入性生物标志物的理想来源。
Abstract:
Diabetic kidney disease(DKD)has become one of the leading causes of end-stage renal disease. The urinary exosomes contain proteins from all cells of the nephron and thousands of RNAs and miRNAs. These substances are transferred between kidney cells, which in turn alter the protein composition and function of the cells, and affect the signal transduction between kidney cells, and participate in the pathogenesis of diabetic kidney disease with the transfer of urinary exosomes. Therefore, urinary exosomes and the abundant biological information contained therein may be an ideal source of non-invasive biomarkers for DKD.

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备注/Memo

备注/Memo:
通信作者:赵艳艳,Email:fcczhaoyy1@zzu.edu.cn
Corresponding author: Zhao Yanyan, Email: fcczhaoyy1@zzu.edu.cn
基金项目:国家自然科学基金(81800734)
Fund program:National Natural Science Foundation of China(81800734)
更新日期/Last Update: 2019-11-20