[1]陈茉 徐书杭 许洋 王雅琳 褚晓秋 刘超.经皮微波消融治疗良性无功能甲状腺结节疗效和超声形态分析[J].国际内分泌代谢杂志,2019,39(05):294-297,301.[doi:10.3760/cma.j.issn.1673-4157.2019.05.002]
　Chen Mo,Xu Shuhang,Xu Yang,et al.Efficacy and ultrasonographic morphologic analysis of ultrasound-guided percutaneous microwave ablation on benign nonfunctioning thyroid nodules[J].International Journal of Endocrinology and Metabolism,2019,39(05):294-297,301.[doi:10.3760/cma.j.issn.1673-4157.2019.05.002]
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经皮微波消融治疗良性无功能甲状腺结节疗效和超声形态分析()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
39
期数:
2019年05期
页码:
294-297,301
栏目:
论著
出版日期:
2019-09-20

文章信息/Info

Title:
Efficacy and ultrasonographic morphologic analysis of ultrasound-guided percutaneous microwave ablation on benign nonfunctioning thyroid nodules
作者:
陈茉 徐书杭 许洋 王雅琳 褚晓秋 刘超
南京中医药大学附属中西医结合医院(江苏省中医药研究院)内分泌科 210028
Author(s):
Chen Mo;  Xu Shuhang;  Xu Yang;  Wang Yalin;  Chu Xiaoqiu;  Liu Chao
Department of Endocrinology, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Traditional Chinese Medicine, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing 210028, China
关键词:
良性甲状腺结节;  微波消融;  热消融;  超声形态
Keywords:
Benign thyroid nodule;  Microwave ablation;  Thermal ablation;  Morphologic ultrasonography
DOI:
10.3760/cma.j.issn.1673-4157.2019.05.002
摘要:
目的 探讨超声引导下经皮微波消融治疗良性无功能甲状腺结节的疗效和超声形态的变化。方法 选取2016年1月1日至2017年12月31日在江苏省中西医结合医院行微波消融治疗良性无功能甲状腺结节的患者37例(37个甲状腺结节),观察治疗前及治疗后第1、6、12个月甲状腺结节的体积、治疗成功率、甲状腺功能、并发症发生率和超声形态的变化。结果 术后12个月时,甲状腺结节体积中位数由5.8 ml减至0.7 ml(Z=-4.20,P<0.001),体积缩小率中位数为86.67%(Z=4.20,P<0.001),有效率可达100.0%(χ2=20.05,P<0.001)。由于结节成分和回声等超声形态的改变,术后甲状腺影像报告和数字系统(TI-RADS)分级显著提高(Z=5.47,P<0.001)。所有患者均未出现严重并发症,微波消融对患者的甲状腺功能和抗体并无影响,但可降低甲状腺球蛋白水平(Z=-2.67,P<0.05)。结论 微波消融治疗良性无功能甲状腺结节具有良好的有效性与安全性,并可改变结节的超声形态特征。
Abstract:
Objective To investigate the efficacy and ultrasonographic morphologic changes of ultrasound-guided percutaneous microwave ablation(MWA)on benign nonfunctioning thyroid nodules.Methods A total of 37 patients with 37 benign thyroid nodules were treated by MWA in Jiangsu Province Academy of Traditional Chinese Medicine from January 1, 2016 to December 31, 2017. The changes of thyroid nodule volume, successful rate of treatment, thyroid function, the incidence of complications and ultrasonographic morphologic changes were observed before treatment as well as at the postoperative 1th, 6th, 12th month follow-up, respectively.Results After 12 months of surgery, the median volume of thyroid nodule significantly decreased from 5.8 ml to 0.7 ml(Z=-4.20, P<0.001). The median volume reduction rate was 86.67%( Z=4.20, P<0.001), and the successful rate of treatment was eventually 100.0%(χ2=20.05, P<0.001). Because of the changes of composition of thyroid nodules and ultrasound echogenicity, the postoperative levels of thyroid imaging report and data system(TI-RADS)were significantly increased(Z=5.47, P<0.001). No serious complications were observed. Thyroid function and autoimmune antibody levels were not affected by MWA. However, serum thyroglobulin level was decreased after MWA(Z=-2.67, P<0.05).Conclusion MWA is safe and effective in treating benign nonfunctioning thyroid nodules,which is able to change ultrasonic morphology as well.

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备注/Memo

备注/Memo:
通信作者:徐书杭,Email:shuhangxu@163.com; 刘超,Email:liuchao@nfmcn.com
Corresponding author: Xu Shuhang, Email:shuhangxu@163.com; Liu Chao, Email:liuchao@nfmcn.com
基金项目:第二批江苏省中医药领军人才项目(SLJ0209); 江苏省医院协会医院管理创新研究课题(JSYGY-1-2018-301); 2018年江苏省研究生科研与实践创新计划面上项目(SJCX18_0470)
Fund program:The Second Batch of Leading Talent of Traditional Chinese Medicine in Jiangsu Province(SLJ0209); Innovation Project on Hospital Management of Jiangsu Provice Hospital Association(JSYGY-1-2018-301); Surface Project on Postgraduate Research & Practice Innovation Program of Jiangsu Province(SJCX18_0470)
更新日期/Last Update: 2019-09-20