[1]梁寒婷 卢琳 朱惠娟.USP8及核受体与库欣病[J].国际内分泌代谢杂志,2019,39(02):131-135.[doi:10.3760/cma.j.issn.1673-4157.2019.02.015]
 Liang Hanting,Lu Lin,Zhu Huijuan.USP8, nuclear receptors and Cushing's disease[J].International Journal of Endocrinology and Metabolism,2019,39(02):131-135.[doi:10.3760/cma.j.issn.1673-4157.2019.02.015]
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USP8及核受体与库欣病()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
39
期数:
2019年02期
页码:
131-135
栏目:
综述
出版日期:
2019-03-20

文章信息/Info

Title:
USP8, nuclear receptors and Cushing's disease
作者:
梁寒婷 卢琳 朱惠娟
中国医学科学院,北京协和医学院,北京协和医院内分泌科,卫生健康委内分泌重点实验室,协和转化医学中心 100730; 中国医学科学院罕见病研究中心,北京 100730
Author(s):
Liang Hanting Lu Lin Zhu Huijuan
Key Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100730, China; Center for Rare Disease Research, Chinese Academy of Medical Sciences, Beijing 100730, China
关键词:
库欣病 泛素特异肽酶8 核受体 促肾上腺皮质激素
Keywords:
Cushing's disease Ubiquitin specific peptidase 8 Nuclear receptor Adrenocorticotropic hormone
DOI:
10.3760/cma.j.issn.1673-4157.2019.02.015
摘要:
库欣病发生、发展的分子机制包括受体类、配体类、相关的转录因子、基因突变、蛋白修饰等,涵盖了促肾上腺皮质激素(ACTH)的产生及分泌的过程。泛素特异肽酶8及主要的核受体包括糖皮质激素受体、睾丸孤核受体4、孤核受体Nur77、视黄酸受体与类视黄醇X受体、肝X受体、过氧化物酶体增殖物活化受体,在库欣病发病机制中具有一定作用,对其深入研究,将为库欣病的早期诊断及潜在的靶向治疗提供思路。
Abstract:
The molecular mechanisms of the occurrence and development of Cushing's disease include receptors, ligands, related transcription factors, gene mutations, protein modifications etc, covering the process of adrenocorticotropic hormone(ACTH)production and secretion. Ubiquitin specific peptidase 8 and major nuclear receptors include glucocorticoid receptor, testicular orphan receptor 4, nuclear receptor Nur77, retinoic acid receptor and retinoid X receptor, liver X receptor, peroxisome proliferator-activated receptor play a role in the pathogenesis of Cushing's disease, and its in-depth study will help to provide the ideas for early diagnosis and potential targeted therapy of Cushing's disease.

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[1]魏薇,王卫庆.库欣病的分子发病机制[J].国际内分泌代谢杂志,2014,(03):203.[doi:10.3760/cma.j.issn.1673-4157.2014.03.017]
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备注/Memo

备注/Memo:
通信作者:朱惠娟, Email:shengxin2004@163.com
基金项目:中国医学科学院医学与健康科技创新工程(2016-I2M-1-002, 2017-I2M-1-011)
Corresponding author: Zhu Huijuan, Email:shengxin2004@163.com
Fund program:CAMS Innovation Fund for Medical Science(2016-I2M-1-002, 2017-I2M-1-011)
更新日期/Last Update: 2019-03-20