[1]严琴慧 李晓南.线粒体自噬与白色脂肪棕色化的关系[J].国际内分泌代谢杂志,2019,39(02):87-90.[doi:10.3760/cma.j.issn.1673-4157.2019.02.004]
　Yan Qinhui,Li Xiaonan.Relationship between mitophagy and browning of white adipose[J].International Journal of Endocrinology and Metabolism,2019,39(02):87-90.[doi:10.3760/cma.j.issn.1673-4157.2019.02.004]
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线粒体自噬与白色脂肪棕色化的关系()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
39
期数:
2019年02期
页码:
87-90
栏目:
综述
出版日期:
2019-03-20

文章信息/Info

Title:
Relationship between mitophagy and browning of white adipose
作者:
严琴慧 李晓南
南京医科大学附属儿童医院儿童保健科 210008
Author(s):
Yan Qinhui;  Li Xiaonan
Department of Child Health Care, Children's Hospital of Nanjing Medical University, Nanjing 210008, China
关键词:
线粒体自噬;  白色脂肪棕色化;  肥胖
Keywords:
Mitophagy;  Browning of white adipose;  Obesity
DOI:
10.3760/cma.j.issn.1673-4157.2019.02.004
摘要:
已知肥胖与多种疾病相关,白色脂肪棕色化作为可能治疗肥胖的新靶点受到了广泛的关注。在白色脂肪棕色化过程中,线粒体的数量和功能会发生明显的变化,而线粒体自噬是调控线粒体数量和控制线粒体质量的重要方式。目前有研究证实,抑制线粒体自噬可阻断脂肪干细胞向白色脂肪细胞分化和促进成熟白色脂肪细胞向米色脂肪细胞转化,但线粒体自噬和白色脂肪棕色化的关系尚不确定,还需进一步探索。
Abstract:
As we all known, obesity is associated with many diseases. Browning of white adipose, as a new way for the treatment of obesity, has received the widespread attention. During the process of white-to-brown, the numbers and function of mitochondria have been significantly changed. Mitophagy is an important way, which changes the number of mitochondria and controls the quality of mitochondria. Recently, some studies have revealed that the inhibition of mitophagy could prevent adipose-derived stem cells from differentiating into white adipocyte and promote the transformation of mature white adipocyte into beige adipocyte. However, the relationship between mitophagy and browning process is still unclear, which needs further study.

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备注/Memo

备注/Memo:
通信作者:李晓南,Email:xnli@njmu.edu.cn
基金项目:国家自然科学基金(81773421)
Corresponding author: Li Xiaonan, Email:xnli@njmu.edu.cn
Fund program:National Natural Science Foundation of China(81773421)
更新日期/Last Update: 2019-03-20