[1]陈俊秀 杜宏.肠道菌群与口服降糖药物[J].国际内分泌代谢杂志,2018,38(05):305-308.[doi:10.3760/cma.j.issn.1673-4157.2018.05.005]
 Chen Junxiu*,Du Hong.Intestinal microbiota and oral hypoglycemic agents[J].International Journal of Endocrinology and Metabolism,2018,38(05):305-308.[doi:10.3760/cma.j.issn.1673-4157.2018.05.005]
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肠道菌群与口服降糖药物()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
38
期数:
2018年05期
页码:
305-308
栏目:
综述
出版日期:
2018-09-20

文章信息/Info

Title:
Intestinal microbiota and oral hypoglycemic agents
作者:
陈俊秀 杜宏
作者单位:210000 南京大学医学院(陈俊秀); 210002 解放军南京总医院内分泌科(杜宏)
Author(s):
Chen Junxiu* Du Hong
*Medical School of Nanjing University, Nanjing 210000, China
关键词:
肠道菌群 口服降糖药物 2型糖尿病
Keywords:
Intestinal microbiota Oral hypoglycemic agents Type 2 diabetes mellitus
DOI:
10.3760/cma.j.issn.1673-4157.2018.05.005
摘要:
人类肠道中微生物与2型糖尿病发展之间的联系越来越明显。肠道菌群可以通过短链脂肪酸、胆汁酸代谢、炎性反应等多种机制来影响2型糖尿病的发展。二甲双胍和α-葡萄糖苷酶抑制剂可能通过其对肠道L细胞的作用,导致胰高血糖素样肽(GLP)-1的分泌增加,达到治疗糖尿病的目的; 中药大黄酸、小檗碱和白术也可以通过改变肠道菌群数量,发挥降糖作用。各种口服降糖药物的具体肠道作用机制还有待进一步研究和阐明。
Abstract:
The link between gut microbiota in human and the development of type 2 diabetes mellitus is becoming more clear. Intestinal microbiota can influence the development of type 2 diabetes mellitus through various mechanisms such as short chain fatty acids, bile acid metabolism, and inflammation. Through their effect on intestinal L cells, metformin and α-glucosidase inhibitors can contribute to treatment of diabetes by increasing the secretion of glucagon-like peptide(GLP)-1; traditional Chinese medicine rhein, berberine and atractylodes can also treat type 2 diabetes mellitus by influencing the number of intestinal microbiota. The specific intestinal mechanism of oral hypoglycemic agents remains to be further studied and clarified.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金(81173622); 江苏省自然科学基金(BK20161384)
作者单位:210000 南京大学医学院(陈俊秀); 210002 解放军南京总医院内分泌科(杜宏)
通信作者:杜宏,Email: duhong5@126.com
更新日期/Last Update: 2018-09-30