[1]徐瑶 王秋月.Akt/FoxOs信号通路与糖尿病肾脏疾病[J].国际内分泌代谢杂志,2018,38(02):117-120.[doi:10.3760/cma.j.issn.1673-4157.2018.02.012]
　Xu Yao,Wang Qiuyue..Akt/FoxOs signal pathway and diabetic kidney disease[J].International Journal of Endocrinology and Metabolism,2018,38(02):117-120.[doi:10.3760/cma.j.issn.1673-4157.2018.02.012]
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Akt/FoxOs信号通路与糖尿病肾脏疾病()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
38
期数:
2018年02期
页码:
117-120
栏目:
综述
出版日期:
2018-03-20

文章信息/Info

Title:
Akt/FoxOs signal pathway and diabetic kidney disease
作者:
徐瑶 王秋月
110001 沈阳,中国医科大学附属第一医院内分泌科
Author(s):
Xu Yao;  Wang Qiuyue.
Deparment of Endocrinology,The First Affiliated Hospital, China Medical University, Shenyang 110001, China
关键词:
蛋白激酶B;  叉头转录因子;  糖尿病肾脏疾病
Keywords:
Protein kinase B;  Forkhead transcription factor;  Diabetic kidney disease
DOI:
10.3760/cma.j.issn.1673-4157.2018.02.012
摘要:
蛋白激酶B(PKB/Akt)/叉头转录因子(FoxO)信号通路是广泛存在于肾脏的重要信号通路。近年来,多种研究表明Akt/FoxO信号通路通过影响氧化应激、细胞增殖和凋亡、细胞外基质堆积、细胞自噬等方面,促进糖尿病肾脏疾病(DKD)的病理生理改变,在DKD的发生、发展中起重要作用。
Abstract:
Protein kinase B(PKB/Akt)/forkhead transcription factor(FoxO)signal pathway is a vital signal pathway which is widely present in kidney. In recent years, a variety of studies have shown that Akt/FoxO signal pathway affected the pathophysiological changes of diabetic kidney disease through affecting oxidative stress, cell proliferation and apoptosis, extracellular matrix deposition, autophagy and so on, which plays an important role in the development and progression of diabetic kidney disease.

参考文献/References:


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备注/Memo

备注/Memo:
基金项目:辽宁省高等学校“高端人才队伍建设工程”项目([2014]187); 辽宁省自然科学基金(201602862)
通信作者:王秋月,Email:wqycmu123@163.com
更新日期/Last Update: 1900-01-01