[1]李扬 薛萌 胡芳 关美萍 薛耀明.Klotho在糖尿病肾脏疾病中的抗纤维化作用[J].国际内分泌代谢杂志,2018,38(01):48-51.[doi:10.3760/cma.j.issn.1673-4157.2018.01.013]
　Li Yang,Xue Meng,Hu Fang,et al.Anti-fibrotic effects of Klotho in diabetic kidney disease[J].International Journal of Endocrinology and Metabolism,2018,38(01):48-51.[doi:10.3760/cma.j.issn.1673-4157.2018.01.013]
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Klotho在糖尿病肾脏疾病中的抗纤维化作用()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
38
期数:
2018年01期
页码:
48-51
栏目:
综述
出版日期:
2018-01-20

文章信息/Info

Title:
Anti-fibrotic effects of Klotho in diabetic kidney disease
作者:
李扬 薛萌 胡芳 关美萍 薛耀明
510515 广州,南方医科大学南方医院内分泌代谢科
Author(s):
Li Yang;  Xue Meng;  Hu Fang;  Guan Meiping;  Xue Yaoming
Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
关键词:
Klotho;  糖尿病肾脏疾病;  肾脏纤维化
Keywords:
Klotho;  Diabetic kidney disease;  Renal fibrosis
DOI:
10.3760/cma.j.issn.1673-4157.2018.01.013
摘要:
Klotho是一种抗衰老蛋白,主要在肾远曲小管表达。近年研究发现,糖尿病肾脏疾病患者早期即出现血清Klotho蛋白水平下降,肾组织内Klotho表达水平亦明显下降,且随着糖尿病肾脏疾病的进展,Klotho蛋白水平进一步降低。在链脲佐菌素诱导的糖尿病动物模型或体外高糖培养的细胞研究中证实,Klotho通过抗氧化应激、抑制转化生长因子-β信号通路、抑制Wnt信号通路、抗炎及抗凋亡等作用发挥抗肾脏纤维化的作用。因此,Klotho蛋白与糖尿病肾脏疾病的发生、发展密切相关。
Abstract:
Klotho is an anti-aging protein, highly expressed in the renal distal convoluted tubules. Recent studies reveal that plasma Klotho decreases in the early stage of patients with diabetic kidney disease(DKD), accompanied by decreased expression of Klotho in kidney. Moreover, protein level of Klotho further decreases with the progressoin of DKD. In streptozotocin induced diabetic animal models or high glucose cultured cell lines in vitro, it has been demonstrated that Klotho prevented renal fibrosis by antioxidation, inhibition of transforming growth factor-β and Wnt signaling, anti-inflammation and anti-apoptosis. Therefore, Klotho is intimately associated with the occurrence and development of DKD.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金(81570724)
通信作者:薛耀明,Email:xueyaoming999@126.com
更新日期/Last Update: 2018-01-30