[1]刘宇,王秋月.microRNA-124与糖尿病肾脏疾病[J].国际内分泌代谢杂志,2017,37(04):246-249.
　Liu Yu,Wang Qiuyue..microRNA-124 and diabetic kidney diseases[J].International Journal of Endocrinology and Metabolism,2017,37(04):246-249.
点击复制

microRNA-124与糖尿病肾脏疾病()
分享到：

《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
37
期数:
2017年04期
页码:
246-249
栏目:
综述
出版日期:
2017-07-20

文章信息/Info

Title:
microRNA-124 and diabetic kidney diseases
作者:
刘宇; 王秋月
110001 沈阳,中国医科大学附属第一医院内分泌与代谢病科
Author(s):
Liu Yu; Wang Qiuyue.
Department of Endocrinology and Metabolism, The First Affiliated Hospital of China Medical University, Shenyang 110001, China
关键词:
microRNA-124;  糖尿病肾脏疾病;  整合素;  Rho/Rho相关蛋白激酶信号通路;  PI3K/Akt信号通路
Keywords:
microRNA-124;  Diabetic kidney disease;  Integrin;  Rho/Rho-associated kinase signaling pathway;  PI3K/Akt signaling pathway
文献标志码:
A
摘要:
microRNA(miRNA)广泛存在于真核生物体内,参与蛋白质的转录和转录后的调控。miRNA具有高度进化保守性及组织特异性,在生物的生长发育、细胞分化、疾病的发展过程中起作用。miRNA-124是microRNAs家族的重要成员,近年研究显示,miRNA-124能够作用于整合素,进而影响肾脏纤维化进程,可能作用于Rho/Rho相关蛋白激酶信号通路,起到保护肾小球滤过屏障的作用,能够作用于信号转导与转录激活因子3、Toll样受体、磷脂酰肌醇3激酶/蛋白激酶B信号通路调节炎性反应,可能成为糖尿病肾脏疾病诊断和治疗的新靶点。
Abstract:
microRNA(miRNA)is widely existed in the eukaryotic organisms, and is involved in the regulation of the transcription and posttranscriptional regulation of proteins. miRNA has a high degree of evolutionary conservation and tissue specificity, which plays an important role in the process of growth and development, cell differentiation and diseases. miRNA-124 is an important member of the family of miRNAs, recent studies showed that miRNA-124 could act on the integrin and influence the process of renal fibrosis, played a role in the Rho/Rho-associated kinase(ROCK)signaling pathway to protect the glomerular filtration barrier function, and affected signal transducer and activator of transcription 3, Toll-like receptors, phosphoinositide 3-kinase/protein kinase B signaling pathways to regulate inflammation reaction, therefore might become a new target for diagnosis and treatment of diabetic kidney disease.

参考文献/References:

[1] Ebert MS, Sharp PA. Roles for microRNAs in conferring robustness to biological processes[J].Cell,2012,149(3):515-524. DOI:10.1016/j.cell.2012.04.005.
[2] Lovis P, Gattesco S, Regazzi R. Regulation of the expression of components of the exocytotic machinery of insulin-secreting cells by microRNAs[J].Biol Chem,2008,389(3):305-312. DOI:10.1515/BC.2008.026.
[3] Qadir AS, Woo KM, Ryoo HM,et al. Insulin suppresses distal-less homeobox 5 expression through the up-regulation of microRNA-124 in 3T3-L1 cells[J].Exp Cell Res,2013,319(14):2125-2134. DOI:10.1016/j.yexcr.2013.04.020.
[4] Ridley AJ. Rho GTPase signalling in cell migration[J].Curr Opin Cell Biol,2015,36:103-112. DOI:10.1016/j.ceb.2015.08.005.
[5] Komers R, Oyama TT, Beard DR,et al. Effects of systemic inhibition of Rho kinase on blood pressure and renal haemodynamics in diabetic rats[J].Br J Pharmacol,2011,162(1):163-174. DOI:10.1111/j.1476-5381.2010.01031.x.
[6] An L, Liu Y, Wu A,et al. microRNA-124 inhibits migration and invasion by down-regulating ROCK1 in glioma[J].PLoS One,2013,8(7):e69478. DOI:10.1371/journal.pone.0069478.
[7] Xu X, Li S, Lin Y,et al. MicroRNA-124-3p inhibits cell migration and invasion in bladder cancer cells by targeting ROCK1[J].J Transl Med,2013,11:276. DOI:10.1186/1479-5876-11-276.
[8] Jun JH, Joo CK. MicroRNA-124 controls transforming growth factor β1-induced epithelial-mesenchymal transition in the retinal pigment epithelium by targeting RHOG[J].Invest Ophthalmol Vis Sci,2016,57(1):12-22. DOI:10.1167/iovs.15-17111.
[9] Wu JH, Gao Y, Ren AJ,et al. Altered microRNA expression profiles in retinas with diabetic retinopathy[J].Ophthalmic Res,2012,47(4):195-201. DOI:10.1159/000331992.
[10] Ishizaka M, Gohda T, Takagi M,et al. Podocyte-specific deletion of Rac1 leads to aggravation of renal injury in STZ-induced diabetic mice[J].Biochem Biophys Res Commun,2015,467(3):549-555. DOI:10.1016/j.bbrc.2015.09.158.
[11] Eid AA, Gorin Y, Fagg BM,et al. Mechanisms of podocyte injury in diabetes: role of cytochrome P450 and NADPH oxidases[J].Diabetes,2009,58(5):1201-111. DOI:10.2337/db08-1536.
[12] Mouawad F, Tsui H, Takano T. Role of Rho-GTPases and their regulatory proteins in glomerular podocyte function[J].Can J Physiol Pharmacol,2013,91(10):773-782. DOI:10.1139/cjpp-2013-0135.
[13] Wang S, Chen C, Su K,et al. Angiotensin Ⅱ induces reorganization of the actin cytoskeleton and myosin light-chain phosphorylation in podocytes through rho/ROCK-signaling pathway[J].Ren Fail,2016,38(2):268-275. DOI:10.3109/0886022X.2015.1117896.
[14] Cao X, Pfaff SL, Gage FH. A functional study of miR-124 in the developing neural tube[J].Genes Dev,2007,21(5):531-536. DOI:10.1101/gad.1519207.
[15] Li D, Lu Z, Jia J,et al. MiR-124 is related to podocytic adhesive capacity damage in STZ-induced uninephrectomized diabetic rats[J].Kidney Blood Press Res,2013,37(4-5):422-431. DOI:10.1159/000355721.
[16] Li D, Lu Z, Jia J,et al. Curcumin ameliorates Podocytic adhesive capacity damage under mechanical stress by inhibiting miR-124 expression[J].Kidney Blood Press Res,2013,38(1):61-71. DOI:10.1159/000355755.
[17] Soetikno V, Suzuki K, Veeraveedu PT,et al. Molecular understanding of curcumin in diabetic nephropathy[J].Drug Discov Today,2013,18(15-16):756-763. DOI:10.1016/j.drudis.2013.04.009.
[18] Vaure C, Liu Y. A comparative review of toll-like receptor 4 expression and functionality indifferent animal species[J].Front Immunol,2014,5:316. DOI:10.3389/fimmu.2014.00316.
[19] Gluba A, Banach M, Hannam S,et al. The role of Toll-like receptors in renal diseases[J].Nat Rev Nephrol,2010,6(4):224-235. DOI:10.1038/nrneph.2010.16.
[20] Ma J, Chadban SJ, Zhao CY,et al. TLR4 activation promotes podocyte injury and interstitial fibrosis in diabetic nephropathy[J].PLoS One,2014,9(5):e97985. DOI:10.1371/journal.pone.0097985.
[21] Qiu S, Feng Y, LeSage G,et al. Chronic morphine-induced microRNA-124 promotes microglial immunosuppression by modulating P65 and TRAF6[J].J Immunol,2015,194(3):1021-1030. DOI:10.4049/jimmunol.1400106.
[22] Chuang PY, He JC. JAK/STAT signaling in renal diseases[J].Kidney Int,2010,78(3):231-234. DOI:10.1038/ki.2010.158.DOI:10.1038/ki.2010.158.
[23] Lu TC, Wang ZH, Feng X,et al. Knockdown of Stat3 activity in vivo prevents diabetic glomerulopathy[J].Kidney Int,2009,76(1):63-71. DOI:10.1038/ki.2009.98.
[24] Wei J, Wang F, Kong LY,et al. miR-124 inhibits STAT3 signaling to enhance T cell-mediated immune clearance of glioma[J].Cancer Res,2013,73(13):3913-3926. DOI:10.1158/0008-5472.CAN-12-4318.
[25] Tian J, Wang Y, Guo H,et al. The Akt/mTOR/p70S6K pathway is activated in IgA nephropathy and rapamycin may represent a viable treatment option[J].Exp Mol Pathol,2015,99(3):435-440. DOI:10.1016/j.yexmp.2015.08.004.
[26] Kato M, Putta S, Wang M,et al. TGF-beta activates Akt kinase through a microRNA-dependent amplifying circuit targeting PTEN[J].Nat Cell Biol,2009,11(7):881-889. DOI:10.1038/ncb1897.
[27] Lang Q, Ling C. MiR-124 suppresses cell proliferation in hepatocellular carcinoma by targeting PIK3CA[J].Biochem Biophys Res Commun,2012,426(2):247-252. DOI:10.1016/j.bbrc.2012.08.075.
[28] Qadir AS, Woo KM, Ryoo HM,et al. Insulin suppresses distal-less homeobox 5 expression through the up-regulation of microRNA-124 in 3T3-L1 cells[J].Exp Cell Res,2013,319(14):2125-2134. DOI:10.1016/j.yexcr.2013.04.020.
[29] Gu X, Meng S, Liu S,et al. miR-124 represses ROCK1 expression to promote neurite elongation through activationof the PI3K/Akt signal pathway[J].J Mol Neurosci,2014,52(1):156-165.DOI:10.1007/s12031-013-0190-6.

相似文献/References:

[1]陈芬琴,王秋月.柚皮苷对糖尿病肾脏疾病的作用机制[J].国际内分泌代谢杂志,2017,37(04):239.
　Chen Fenqin*,Wang Qiuyue..The mechanisms of naringin on diabetic kidney diseases[J].International Journal of Endocrinology and Metabolism,2017,37(04):239.
[2]邓雪凤,曹雪亭,杨萍,等.慢性低度炎性反应与糖尿病肾脏疾病的 相关性分析:一项大样本病例-对照研究[J].国际内分泌代谢杂志,2017,37(06):373.
　Deng Xuefeng,Cao Xueting,Yang Ping,et al.Relationship between chronic low-grade inflammation and diabetic kidney disease: a large case-control study[J].International Journal of Endocrinology and Metabolism,2017,37(04):373.
[3]李扬 薛萌 胡芳 关美萍 薛耀明.Klotho在糖尿病肾脏疾病中的抗纤维化作用[J].国际内分泌代谢杂志,2018,38(01):48.[doi:10.3760/cma.j.issn.1673-4157.2018.01.013]
　Li Yang,Xue Meng,Hu Fang,et al.Anti-fibrotic effects of Klotho in diabetic kidney disease[J].International Journal of Endocrinology and Metabolism,2018,38(04):48.[doi:10.3760/cma.j.issn.1673-4157.2018.01.013]
[4]徐瑶 王秋月.Akt/FoxOs信号通路与糖尿病肾脏疾病[J].国际内分泌代谢杂志,2018,38(02):117.[doi:10.3760/cma.j.issn.1673-4157.2018.02.012]
　Xu Yao,Wang Qiuyue..Akt/FoxOs signal pathway and diabetic kidney disease[J].International Journal of Endocrinology and Metabolism,2018,38(04):117.[doi:10.3760/cma.j.issn.1673-4157.2018.02.012]
[5]王珊珊 俞冰鸿 傅雯雯 杨艳辉 孔岩 王靖宇 常宝成 郑妙艳 杨菊红 王颖许杰 单春艳.亚临床甲状腺功能减退症与2型糖尿病肾功能损伤的相关性研究[J].国际内分泌代谢杂志,2019,39(06):368.[doi:10.3760/cma.j.issn.1673-4157.2019.06.002]
　Wang Shanshan,Yu Binghong,Fu Wenwen,et al.Correlation between subclinical hypothyroidism and renal function injury in patients with type 2 diabetes mellitus[J].International Journal of Endocrinology and Metabolism,2019,39(04):368.[doi:10.3760/cma.j.issn.1673-4157.2019.06.002]
[6]申奥 赵艳艳.尿外泌体与糖尿病肾脏疾病[J].国际内分泌代谢杂志,2019,39(06):391.[doi:10.3760/cma.j.issn.1673-4157.2019.06.007]
　Shen Ao,Zhao Yanyan.Urinary exosomes and diabetic kidney disease[J].International Journal of Endocrinology and Metabolism,2019,39(04):391.[doi:10.3760/cma.j.issn.1673-4157.2019.06.007]
[7]袁紫东 王秋月.LPA/LPA1信号通路与糖尿病肾脏疾病[J].国际内分泌代谢杂志,2020,40(01):55.[doi:10.3760/cma.j.issn.1673-4157.2020.01.013]
　Yuan Zidong,Wang Qiuyue.LPA/LPA1 signaling pathway and diabetic kidney disease[J].International Journal of Endocrinology and Metabolism,2020,40(04):55.[doi:10.3760/cma.j.issn.1673-4157.2020.01.013]

备注/Memo

备注/Memo:
基金项目:辽宁省高等学校“高端人才队伍建设工程”项目([2014]187)
通信作者:王秋月,Email: wqycmu@163.com
更新日期/Last Update: 2017-07-30