[1]徐传翀,尚文斌.脂肪固有免疫细胞与胰岛素抵抗[J].国际内分泌代谢杂志,2016,36(04):257-260.[doi:10.3760/cma.j.issn.1673-4157.2016.04.11]
 Xu Chuanchong,Shang Wenbin.Innate immune cells in adipose tissue and insulin resistance[J].International Journal of Endocrinology and Metabolism,2016,36(04):257-260.[doi:10.3760/cma.j.issn.1673-4157.2016.04.11]
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脂肪固有免疫细胞与胰岛素抵抗()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
36
期数:
2016年04期
页码:
257-260
栏目:
综述
出版日期:
2016-07-20

文章信息/Info

Title:
Innate immune cells in adipose tissue and insulin resistance
作者:
徐传翀尚文斌
210023 南京中医药大学第一临床医学院,代谢病中医研究重点实验室
Author(s):
Xu Chuanchong Shang Wenbin
Key Laboratory for Metabolic Diseases in Chinese Medicine,First College of Clinical Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China
关键词:
胰岛素抵抗 固有免疫细胞 脂肪组织 炎症
Keywords:
Insulin resistance Innate immune cells Adipose tissue Inflammation
DOI:
10.3760/cma.j.issn.1673-4157.2016.04.11
摘要:
胰岛素抵抗是指外周组织对胰岛素敏感性及反应性降低,肥胖是胰岛素抵抗的主要原因。近年来研究显示,脂肪组织内的炎性反应状态与胰岛素抵抗及2型糖尿病等代谢疾病之间存在密切关系,而脂肪组织中的巨噬细胞、肥大细胞、中性粒细胞、树突状细胞、嗜酸性粒细胞以及自然杀伤T细胞等多种固有免疫细胞通过活化和释放炎性反应介质,参与炎性反应,从而促进机体胰岛素抵抗的形成。进一步深入阐明固有免疫细胞在脂肪组织炎性反应和胰岛素抵抗方面的作用,可以为糖尿病基础研究和治疗提供新的方向和思路。
Abstract:
Insulin resistance(IR)refers to the reduced sensitivity and reactivity of insulin in peripheral tissue,while obesity is a major cause of it. In recent years, researches have shown that there is a close relationship between adipose tissue inflammation and metabolic diseases, such as IR and type 2 diabetes. A variety of innate immune cells in adipose tissue involve in the inflammatory response through activation and release of inflammatory mediators,such as macrophage,mast cell,neutrophil,dendritic cell,eosinophil,natural killer T cell, thus inducing IR. Further clarification of the role of innate immune cells in adipose tissue inflammation and IR will provide a new direction for basic research and treatment of diabetes.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金面上项目(81473391) 通信作者:尚文斌,Email:wbshang@njucm.edu.cn
更新日期/Last Update: 2016-09-20