[1]严克敏,龚凤英.Betatrophin与胰岛β细胞增殖及糖脂代谢的关系[J].国际内分泌代谢杂志,2016,36(04):253-256,265.[doi:10.3760/cma.j.issn.1673-4157.2016.04.10]
　Yan Kemin,Gong Fengying.Relationships between betatrophin, islet β cell proliferation and glucose-lipid metabolism[J].International Journal of Endocrinology and Metabolism,2016,36(04):253-256,265.[doi:10.3760/cma.j.issn.1673-4157.2016.04.10]
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Betatrophin与胰岛β细胞增殖及糖脂代谢的关系()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
36
期数:
2016年04期
页码:
253-256,265
栏目:
综述
出版日期:
2016-07-20

文章信息/Info

Title:
Relationships between betatrophin, islet β cell proliferation and glucose-lipid metabolism
作者:
严克敏; 龚凤英
100730 北京,中国医学科学院,北京协和医学院,北京协和医院内分泌科,卫生部内分泌重点实验室,协和转化医学中心
Author(s):
Yan Kemin;  Gong Fengying
Department of Endocrinology, Key Laboratory of Endocrinology of Ministry of Health, The Translational Medicine Center of PUMCH, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences&Peking Union Medical College, Beijing 100730, China
关键词:
Betatrophin;  β细胞增殖;  糖代谢;  脂代谢
Keywords:
Betatrophin;  β cell proliferation;  Glucose metabolism;  Lipid metabolism
DOI:
10.3760/cma.j.issn.1673-4157.2016.04.10
摘要:
Betatrophin是2013年Yi等研究发现的、主要由肝脏和脂肪组织产生的分泌性蛋白质。其通过调节细胞周期相关因子的表达,显著且特异性地促进小鼠胰岛β细胞的增殖。此外,betatrophin还能改善小鼠的糖耐量,参与糖、脂代谢的调节。Betatrophin促进胰岛β细胞增殖、改善糖耐量的作用,使其有望成为糖尿病治疗的新靶点。
Abstract:
Betatrophin, which was found by Yi et al in 2013, is a secreted protein mainly produced by liver and adipose tissue. Betatrophin can promote pancreatic β cell proliferation significantly and specifically in mice by regulating the expression of cell cycle related factors. Moreover, betatrophin can also improve glucose tolerance in mice and participate in the regulation of glucose and lipid metabolism. The function of betatrophin that promoting β cell proliferation and improving glucose tolerance makes it prospectively to be a new target in the treatment of diabetes.

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相似文献/References:

[1]吕丹 李晓思 陈树春 王泽普.Betatrophin:糖尿病再生治疗的新希望[J].国际内分泌代谢杂志,2015,(05):351.[doi:DOI:10.3760/cma.j.issn.1673-4157.2015.05.016]
　Lyu Dan*,Li Xiaosi,Chen Shuchun,et al.Betatrophin:new hope for regeneration therapy of diabetes[J].International Journal of Endocrinology and Metabolism,2015,(04):351.[doi:DOI:10.3760/cma.j.issn.1673-4157.2015.05.016]

备注/Memo

备注/Memo:
通信作者:龚凤英,Email:fygong@aliyun.com
更新日期/Last Update: 2016-09-20