[1]刘琳,高鑫.肥胖与心脏结构及功能的改变[J].国际内分泌代谢杂志,2015,(03):187-189.[doi:10.3760/cma.j.issn.1673-4157.2015.03.012]
　Liu Lin,Gao Xin..Relationship between obesity and changes of cardiac structure and function[J].International Journal of Endocrinology and Metabolism,2015,(03):187-189.[doi:10.3760/cma.j.issn.1673-4157.2015.03.012]
点击复制

肥胖与心脏结构及功能的改变()
分享到：

《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
期数:
2015年03
页码:
187-189
栏目:
综述
出版日期:
2015-05-20

文章信息/Info

Title:
Relationship between obesity and changes of cardiac structure and function
作者:
刘琳; 高鑫
200032　上海，复旦大学附属中山医院内分泌科
Author(s):
Liu Lin; Gao Xin.
Department of Endocrinology，Zhongshan Hospital，Fudan University，Shanghai 200032，China Corresponding author：Gao Xin，Email：happy20061208@126.com
关键词:
肥胖; 心脏结构; 心脏功能
Keywords:
Obesity; Cardiac structure; Cardiac function
DOI:
10.3760/cma.j.issn.1673-4157.2015.03.012
摘要:
肥胖者心血管疾病风险增加。研究发现肥胖引起的心脏结构及功能的改变，主要表现为心室重构和心室肥厚，以及心室舒张和收缩功能障碍，这些结构及功能异常严重时可引起心脏衰竭。而肥胖者心脏结构和功能的改变受到多种因素影响，包括血流动力学异常、代谢紊乱、炎性反应、线粒体功能障碍和氧化应激以及神经体液因素。多数研究都发现，减轻体重尤其是减重手术能够逆转肥胖引起的心脏结构和功能改变。
Abstract:
The risk of cardiovascular disease is increased in obese patients. Changes in cardiac structure and function such as ventricular remodeling and hypertrophy as well as diastolic and systolic dysfunction exist in obese patients. These structural and functional abnormalities can eventually cause heart failure. These changes are caused by multiple factors，including the hemodynamic abnormalities，metabolic disorders， inflammation，mitochondrial dysfunction，oxidative stress，and neurohormonal factors. Most studies have found that changes in cardiac structure and function can be reversed by medications of weight loss，especially by bariatric surgery.

参考文献/References:

[1]　Cuspidi C，Rescaldani M，Sala C，et al.Left-ventricular hypertrophy and obesity：a systematic review and meta-analysis of echocar-diographic studies[J].J Hypertens，2014，32（1）：16-25. 　
[2]　Rider OJ，Lewandowski A，Nethononda R，et al.Gender-specific differences in left ventricular remodeling in obesity：insights from cardiovascular magnetic resonance imaging[J].Eur Heart J，2013，34（4）：292-299. 　
[3]　Ito K，Date T，Kawai M，et al.Morphological change of left atrium in obese individuals[J].Int J Cardiol，2011，152（1）：117-119. 　
[4]　Abed HS，Samuel CS，Lau DH，et al.Obesity results in progres-sive atrial structural and electrical remodeling：implications for atrial fibrillation[J].Heart Rhythm，2013，10（1）：90-100. 　
[5]　Chahal H，McClelland RL，Tandri H，et al.Obesity and right ventricular structure and function：the MESA-Right Ventricle Study[J].Chest，2012，141（2）：388-395. 　
[6]　Haddad F，Hunt SA，Rosenthal DN，et al.Right ventricular function in cardiovascular disease，part I：anatomy，physiology，aging， and functional assessment of the right ventricle[J].Circulation，2008，117（11）：1436-1448. 　
[7]　Mahajan R，Lau DH，Sanders P.Impact of obesity on cardiac metabolism，fibrosis，and function[J].Trends Cardiovasc Med，2015， 25（2）：119-126. 　
[8]　Russo C，Jin Z，Homma S，et al.Effect of obesity and overweight on left ventricular diastolic function：a community-based study in an elderly cohort[J].J Am Coll Cardiol，2011，57（57）：1368-1374. 　
[9]　Di Salvo G，Pacileo G，Del Giudice EM，et al.Abnormal myocardial deformation properties in obese， non-hypertensive children：an ambulatory blood pressure monitoring，standard echocardiographic，and strain rate imaging study[J].Eur Heart J，2006，27（22）：2689-2695.
[10]　Orhan AL，Uslu N，Dayi SU，et al.Effects of isolated obesity on left and right ventricular function：a tissue Doppler and strain rate imaging study[J].Echocardiography，2010，27（3）：236-243.
[11]　Aurigemma GP，de Simone G，Fitzgibbons TP.Cardiac remodeling in obesity[J].Circ Cardiovasc Imaging，2013，6（1）：142-152.
[12]　Peterson LR，Herrero P，Schechtman KB，et al.Effect of obesity and insulin resistance on myocardial substrate metabolism and efficiency in young women[J].Circulation，2004，109（18）：2191-2196.
[13]　Boudina S，Sena S，Theobald H，et al.Mitochondrial energetics in the heart in obesity-related diabetes：direct evidence for increased uncoupled respiration and activation of uncoupling proteins[J].Diabetes，2007，56（10）：2457-2466.
[14]　Lumeng CN，Saltiel AR.Inflammatory links between obesity and metabolic disease[J].J Clin Invest，2011，121（6）：2111-2117.
[15]　Kong P，Christia P，Frangogiannis NG.The pathogenesis of cardiac fibrosis[J].Cell Mol Life Sci，2014，71（4）：549-574.
[16]　Cavalera M，Wang J，Frangogiannis NG.Obesity，metabolic dysfunction，and cardiac fibrosis：pathophysiological pathways，molecular mechanisms，and therapeutic opportunities[J].Transl Res，2014，164（4）：323-335.
[17]　Rider OJ，Francis JM，Ali MK，et al.Beneficial cardiovascular effects of bariatric surgical and dietary weight loss in obesity[J].J Am Coll Cardiol，2009，54（8）：718-726.
[18]　Takatsu M，Nakashima C，Takahashi K，et al.Calorie restriction attenuates cardiac remodeling and diastolic dysfunction in a rat model of metabolic syndrome[J].Hypertension，2013，62（5）：957-965.
[19]　Haufe S，Utz W，Engeli S，et al.Left ventricular mass and function with reduced-fat or reduced-carbohydrate hypocaloric diets in overweight and obese subjects[J].Hypertension，2012，59（1）：70-75.
[20]　de las Fuentes L，Waggoner AD，Mohammed BS，et al.Effect of moderate diet-induced weight loss and weight regain on cardio-vascular structure and function[J].J Am Coll Cardiol，2009，54（25）：2376-2381.
[21]　Ippisch HM，Inge TH，Daniels SR，et al.Reversibility of cardiac abnormalities in morbidly obese adolescents[J].J Am Coll Cardiol，2008，51（14）：1342-1348.
[22]　Owan T，Avelar E，Morley K，et al.Favorable changes in cardiac geometry and function following gastric bypass surgery：2-year follow-up in the Utah obesity study[J].J Am Coll Cardiol，2011，57（6）：732-739.
[23]　Vest AR，Heneghan HM，Agarwal S，et al.Bariatric surgery and cardiovascular outcomes：a systematic review[J].Heart，2012，98（24）：1763-1777.

相似文献/References:

[1]刘艳清 易秋艳 邵加庆.肠道菌群与肥胖和糖尿病的关系[J].国际内分泌代谢杂志,2015,(01):31.[doi:DOI：10.3760/cma.j.issn.1673-4157.2015.01.007]
　Liu Yanqing,Yi Qiuyan,Shao Jiaqing..Relationship between gut microbiota, obesity and diabetes[J].International Journal of Endocrinology and Metabolism,2015,(03):31.[doi:DOI：10.3760/cma.j.issn.1673-4157.2015.01.007]
[2]姚旻 赵爱源 张宏.肠道菌群与2型糖尿病[J].国际内分泌代谢杂志,2015,(01):35.[doi:DOI：10.3760/cma.j.issn.1673-4157.2015.01.008]
　Yao Min*,Zhao Aiyuan,Zhang Hong..Relationship between gut microbiota and type 2 diabetes[J].International Journal of Endocrinology and Metabolism,2015,(03):35.[doi:DOI：10.3760/cma.j.issn.1673-4157.2015.01.008]
[3]胡明玥 沈山梅.棕色脂肪检测技术的研究进展[J].国际内分泌代谢杂志,2015,(01):41.[doi:10.3760/cma.j.issn.1673-4157.2015.01.010]
　Hu Mingyue*,Shen Shanmei..Assessments of brown adipose tissue Hu Mingyue*,Shen Shanmei.*Medical College of Southeast University,Nanjing 210009,China[J].International Journal of Endocrinology and Metabolism,2015,(03):41.[doi:10.3760/cma.j.issn.1673-4157.2015.01.010]
[4]郑仁东,曹琳,刘克冕,等.超重或肥胖的男性2型糖尿病患者 性激素水平的研究[J].国际内分泌代谢杂志,2015,(02):84.[doi:10.3760/cma.j.issn.1673-4157.2015.02.004]
　Zheng Rendong,Cao Lin,Liu Kemian,et al.Study on sex hormone levels in overweight or obese type 2 diabetic male patients[J].International Journal of Endocrinology and Metabolism,2015,(03):84.[doi:10.3760/cma.j.issn.1673-4157.2015.02.004]
[5]王滢,李倩.脑利钠肽与糖脂代谢的关系[J].国际内分泌代谢杂志,2015,(02):103.[doi:10.3760/cma.j.issn.1673-4157.2015.02.008]
　Wang Ying,Li Qian..Association between brain natriuretic peptide and glycolipid metabolism[J].International Journal of Endocrinology and Metabolism,2015,(03):103.[doi:10.3760/cma.j.issn.1673-4157.2015.02.008]
[6]王兴纯,程晓芸,曲伸.代餐饮食对代谢紊乱改善的作用及其机制[J].国际内分泌代谢杂志,2015,(02):106.[doi:10.3760/cma.j.issn.1673-4157.2015.02.009]
　Wang Xingchun,Cheng Xiaoyun,Qu Shen..Roles of meal replacement in the improvement of metabolic disorders and related mechanism[J].International Journal of Endocrinology and Metabolism,2015,(03):106.[doi:10.3760/cma.j.issn.1673-4157.2015.02.009]
[7]贺肴,张弛,刘瑛,等.代谢正常肥胖合并非酒精性脂肪性肝病的临床特征及内皮功能研究[J].国际内分泌代谢杂志,2015,(03):163.[doi:10.3760/cma.j.issn.1673-4157.2015.03.005]
　He Yao,Zhang Chi,Liu Ying,et al.Clinical features and endothelial function in metabolically healthy obese patients with nonalcoholic fatty liver disease[J].International Journal of Endocrinology and Metabolism,2015,(03):163.[doi:10.3760/cma.j.issn.1673-4157.2015.03.005]
[8]黄莉吉,谢绍锋,刘超.肥胖相关性肾病的研究进展[J].国际内分泌代谢杂志,2015,(03):180.[doi:10.3760/cma.j.issn.1673-4157.2015.03.010]
　Huang Liji*,Xie Shaofeng,Liu Chao..Obesity-related glomerulopathy[J].International Journal of Endocrinology and Metabolism,2015,(03):180.[doi:10.3760/cma.j.issn.1673-4157.2015.03.010]
[9]刘美娟,朱惠娟,龚凤英.Glypican-，4与肥胖及胰岛素抵抗[J].国际内分泌代谢杂志,2015,(03):183.[doi:10.3760/cma.j.issn.1673-4157.2015.03.011]
　Liu Meijuan,Zhu Huijuan,Gong Fengying..Glypican-4 and obesity，insulin resistance[J].International Journal of Endocrinology and Metabolism,2015,(03):183.[doi:10.3760/cma.j.issn.1673-4157.2015.03.011]
[10]黄桥,白洁,杜洪泉.一种新的脂肪细胞因子——cartonectin[J].国际内分泌代谢杂志,2015,(04):265.[doi:10.3760/cma.j.issn.1673-4157.2015.04.014]
　Huang Qiao*,Bai Jie,Du Hongquan..A novel adipokine--cartonectin[J].International Journal of Endocrinology and Metabolism,2015,(03):265.[doi:10.3760/cma.j.issn.1673-4157.2015.04.014]

备注/Memo

备注/Memo:
通信作者：高鑫，Email: happy20061208@126.com
更新日期/Last Update: 2015-05-20