[1]陈堃,陈国芳,郑仁东,等.碳酸锂对甲状腺功能和形态的影响[J].国际内分泌代谢杂志,2014,(04):248-249，256.[doi:10.3760/cma.j.issn.1673-4157.2014.04.009]
Chen Kun,Chen Guofang,Zheng Rendong,et al.Effects of carbonate lithium therapy on morphology and function of thyroid gland[J].International Journal of Endocrinology and Metabolism,2014,(04):248-249，256.[doi:10.3760/cma.j.issn.1673-4157.2014.04.009]
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碳酸锂对甲状腺功能和形态的影响(
)
《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]
- 卷:
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- 期数:
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2014年04期
- 页码:
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248-249，256
- 栏目:
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甲状腺疾病专栏
- 出版日期:
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2014-08-31
文章信息/Info
- Title:
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Effects of carbonate lithium therapy on morphology and function of thyroid gland
- 作者:
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陈堃; 陈国芳; 郑仁东; 刘超
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作者单位：210028 南京，中国中医科学院江苏分院，南京中医药大学附属中西医结合医院内分泌代谢病院区
- Author(s):
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Chen Kun; Chen Guofang; Zheng Rendong; Liu Chao.
-
Endocrine and Diabetes Center，Jiangsu Province Hospital on Integration of Chinese and Western Medicine，Nanjing University of Traditional Chinese Medicine，Jiangsu Branch of China Academy of Chinese Medical Science，Nanjing 210028， China
Corresponding author
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- 关键词:
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锂治疗; 甲状腺异常; 甲状腺功能减退症; 甲状腺功能亢进症; 甲状腺肿
- Keywords:
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Lithium therapy; Thyroid abnormalities; Hypothyroidism; Hyperthyroidism; Goiter
- DOI:
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10.3760/cma.j.issn.1673-4157.2014.04.009
- 摘要:
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碳酸锂是用于治疗急性躁狂症，单向或双向抑郁以及预防精神障碍的基础药物。治疗中发现碳酸锂可影响甲状腺激素水平及甲状腺大小，患者可出现临床或者亚临床甲状腺功能减退症、甲状腺功能亢进症以及甲状腺肿大等不良反应，在长期使用过程中主要易造成甲状腺功能减退症及甲状腺肿大，其原理可能涉及锂抑制甲状腺激素的合成和释放等，但目前发病率和机制尚未完全明确，值得进一步研究和关注。
- Abstract:
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Lithium is a fundamental drug used in the management of acute mania，unipolar and bipolar depression and prophylaxis of bipolar disorders. It has been proved that lithium treatment may affect thyroid hormone levels and thyroid size，resulting in clinical or subclinical hypothyroidism，hyperthyroidism， goiter and so on. Hypothyroidism and goiter are the major adverse effects in long-term use of lithium. The mechanism may involve the inhibition of lithium on the synthesis and release of thyroid hormone，but the precise prevalance and pathogenesis are not clear. More attention should be paid to the relationship between carbonate lithium therapy and thyroid disorders.
参考文献/References:
[1] López-Jaramillo C，Lopera-Vásquez J，Ospina-Duque J，et al. Lithium treatment effects on the neuropsychological functioning of patients with bipolar I disorder[J].J Clin Psychiatry，2010，71（8）：1055-1060.
[2] Bocchetta A，Loviselli A.Lithium treatment and thyroid abnor-malities[J].Clin Pract Epidemiol Ment Health，2006，2：23.
[3] Emerson CH，Dysno WL，Utiger RD.Serum thyrotropin and thyroxine concentrations in patients recieving Lithium carbonate[J].J Clin Endocrinol Metab，1973，36（2）：338-346.
[4] Kirov G，Tredget J，John R，et al.A cross-sectional and a prospective study of thyroid disorders in lithium-treated patients[J].J Affect Disord，2005，87（2-3）：313-317.
[5] Johnston AE.Risk factors-lithium-associated clinical hypothy-roidism[J].Br J Psychiatry，1999，175：336-339.
[6] Lazarus JH.Lithium and thyroid[J].Best Pract Res Clin Endocrinol Metab，2009，23（6）：723-733.
[7] Chakrabarti S.Thyroid functions and bipolar affective disorder. J Thyroid Res，2011，2011：306367.
[8] Kirov G.Thyroid disorders in lithium-treated patients[J].J Affect Disord，1998，50（1）：33-40.
[9] Bocchetta A，Cocco F，Velluzzi F，et al.Fifteen-year follow-up of thyroid function in Lithium patients[J].J Endocrinol Invest， 2007，
30（5）：363-366.
[10] Miller KK，Daniels GH.Association between Lithium use and thyrotoxicosis caused by silent thyroiditis[J].Clin Endocrinol （Oxf）， 2001，55（4）：501-508.
[11] Brownlie B.Turner J.Lithium associated thyrotoxicosis[J].Clin Endocrinol（Oxf），2011，75（3）：402-403.
[12] Wilson R，Mckillop JH，Crocket GT，et al.The effect of Lithium therapy on parameters thought to be involved in the develop-ment of autoimmune thyroid disease[J].Clin Endocrinol （Oxf），1991，34（5）：357-361.
[13] Schou M，Amdisen A，Eskjaer Jensen S，et al.Occurrence of goitre during Lithium treatment[J].Br Med J，1968，3（5620）：710-713.
[14] Bocchetta A，Bernardi F，Pedditzi M，et al.Thyroid abnormalities during Lithium treatment[J].Acta Psychiatr Scand，1991，83：193-198.
[15] Bauer M，Blumentritt H，Finke R，et al.Using ultrasonography to determine thyroid size and prevalence of goiter in lithium-treated patients with affective disorders[J].J Affect Disord，2007，104（1-3）：45-51.
[16] Barbesino G.Drugs affecting thyroid function[J].Thyroid， 2010，20（7）：763-770.
[17] Rao AS，Kremenevskaja N，Resch J，et al.Lithium stimulates proliferation in cultured thyrocytes by activating Wnt/beta-catenin signalling[J].Eur J Endocrinol，2005，153（6）：929-938
[18] Bocchetta A，Cherchi A，Loviselli A，et al.Six-year follow-up of thyroid function during Lithium treatment[J].Acta Psychiatr Scand，1996，94（1）：45-48.
备注/Memo
- 备注/Memo:
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通信作者：刘超，Email：liuchao@nfmcn.com
更新日期/Last Update:
2014-07-20