[1]任惠珠,杨菊红,郑妙艳,等.肾炎康复片对早期糖尿病肾病患者肾小球、肾小管标志性蛋白/酶的影响[J].国际内分泌代谢杂志,2014,(03):158-161.[doi:10.3760/cma.j.issn.1673-4157.2014.03.004]
　Ren Huizhu,Yang Juhong,Zheng Miaoyan,et al.Effects of Shenyankangfu tablet on glomerular and tubular iconic protein/enzyme in patients with early diabetic nephropathy[J].International Journal of Endocrinology and Metabolism,2014,(03):158-161.[doi:10.3760/cma.j.issn.1673-4157.2014.03.004]
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肾炎康复片对早期糖尿病肾病患者肾小球、肾小管标志性蛋白/酶的影响()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
期数:
2014年03期
页码:
158-161
栏目:
论著
出版日期:
2014-06-30

文章信息/Info

Title:
Effects of Shenyankangfu tablet on glomerular and tubular iconic protein/enzyme in patients with early diabetic nephropathy
作者:
任惠珠; 杨菊红; 郑妙艳; 王颖; 孔岩; 郭航; 单春艳
300070　天津医科大学代谢病医院糖尿病肾病科,卫生部激素与发育重点实验室 　　
Author(s):
Ren Huizhu; Yang Juhong; Zheng Miaoyan; Wang Ying; Kong Yan; Guo Hang; Shan Chunyan.
Department of Nephrology,The Metabolic Disease Hospital, Tianjin Medical University,Key Lab of Hormones and Development,Ministry of Health,Tianjin 300070,China Corresponding author:Shan Chunyan,Email:chunyanshan@hotmail.com
关键词:
肾炎康复片; 早期糖尿病肾病; 肾小球; 肾小管; 标志性蛋白/酶
Keywords:
Shenyankangfu tablet; Early diabetic nephropathy; Glomerular; Tubular; Iconic pro-tein/enzyme
DOI:
10.3760/cma.j.issn.1673-4157.2014.03.004
摘要:
目的　研究肾炎康复片对早期糖尿病肾病患者肾小球、肾小管标志性蛋白/酶的影响。方法　早期糖尿病肾病患者50例,随机分为治疗组和对照组,各25例,两组均采用糖尿病适宜的饮食、运动方案,在控制血糖、血脂等基础上,治疗组给予肾炎康复片5片,每日3次口服,3个月为1个疗程,对照组给予安慰剂。观察治疗前、后两组血肌酐（Scr）、尿素氮（BUN）、糖化血红蛋白A1c（HbA1c）、超敏C反应蛋白（hs-CRP）及24 h尿总蛋白、白蛋白、N-乙酰-β-氨基葡萄糖苷酶（NAG）、β2-微球蛋白（β2-MG）、视黄醇结合蛋白（RBP）的变化。结果　治疗组治疗后血hs-CRP由（4.52±2.01） mg/L降至（3.09±0.85） mg/L,尿NAG由（19.28±7.04） U/L降至（13.70±6.61） U/L,β2-MG由（0.56±0.13） mg/L降至（0.35±0.20） mg/L,RBP由（2.83±1.21） mg/L降至（1.40±0.69） mg/L,较治疗前明显下降,差异有统计学意义（t值分别为2.808,4.523,3.418,3.977,P ＜0.05）,而对照组治疗前、后无明显变化（P 均＞0.05）。治疗组治疗后24 h尿总蛋白由（0.40±0.12） g/24 h降至（0.28±0.15） g/24 h,ALB由（105.91±41.50） mg/24 h降至（65.05±42.52） mg/24 h,治疗前、后差异有统计学意义（t值分别为5.726,4.234,P 均＜0.05）,对照组24 h尿总蛋白和ALB也均下降（t值分别为2.325,1.701,P 均＜0.05）,但治疗组下降更明显（P ＜0.05）。结论　肾炎康复片可减少肾小球性尿白蛋白排泄,减轻肾小管损伤。
Abstract:
Objective　To investigate the effects of Shenyankangfu tablet on glomerular and tubular iconic protein/enzyme in patients with early diabetic nephropathy. Methods　Fifty patients with early diabetic nephropathy were randomly divided into treatment group（n=25） and control group（n=25）.Both groups adopted the diabetic diet,exercise programs. Patients in the treatment group were treated with Shenyankangfu tablet on the base of their blood glucose and lipids control,while patients in the control group received placebo.The changes of serum creatinine（Scr）,blood urea nitrogen（BUN）,glycated hemoglobulinA1c（HbA1c）,hs-C reactive protein（CRP）,and 24-hour urine total protein,albumin,N-acetyl-β-amino-glucosidase （NAG）,β2-microglobulin （β2-MG）,retinol binding protein （RBP） before and after the treatment were tested. Results　The blood hs-CRP,urinary NAG dropped,β2-MG,RBP decreased significantly in treatment group（all P ＜0.05）,but did not change in control group （all P ＞0.05）.The level of blood hs-CRP decreased from （4.52±2.01） mg/L to （3.09±0.85） mg/L,urinary NAG dropped from（19.28±7.04） U/L to （13.70±6.61） U/L,β2-MG reduced from （0.56±0.13） mg/L to （0.35±0.20） mg/L,RBP decreased from （2.83±1.21） mg/L to （1.40±0.69） mg/L respectively（t value were 2.808,4.523,3.418 and 3.977,all P ＜0.05） in treatment group.After treatment,24-hour urinary total protein and albumin decreased in both groups （all P ＜0.05）,but reduced more in treatment group（P ＜0.05）. The level of 24-hour urinary total protein decreased from（0.40±0.12） g/24 h to（0.28±0.15） g/24 h,and urinary albumin decreased from（105.91±41.50） mg/24 h to（65.05±42.52） mg/24 h,respectively（t value were 5.726,4.234,all P ＜0.05） in treatment group. Conclusion　 Shenyankangfu tablet can reduce glomerular urinary protein excretion and tubular injury.

参考文献/References:

　[1]　Phillips AO,Steadman R.Diabetic nephropathy：the central role of renal proximal tubular cells in tubulointerstitial injury[J].Histol Histopathol,2002,17(1)：247-252. 　
[2]　Bonventre JV.Can we target tubular damage to prevent renal function decline in diabetes?[J].Semin Nephrol,2012,32（5）：452-462. 　
[3]　Vallon V.The proximal tubule in the pathophysiology of the diabetic kidney[J].Am J Physiol Regul Integr Comp Physiol,2011,300（5）：R1009-R1022. 　
[4]　Jenkin KA,Verty AN,McAinch AJ,et al.Endocannabinoids and the renal proximal tubule：an emerging role in diabetic nephropathy[J].Int J Biochem Cell Biol,2012,44（11）：2028-2031. 　
[5]　Kim SS,Song SH,Kim IJ,et al.Urinary cystatin C and tubular proteinuria predict progression of diabetic nephropathy[J].Diabetes Care,2013,36（3）：656-661. 　
[6]　Moresco RN,Sangoi MB,De Carvalho JA,et al.Diabetic neph- ropathy：traditional to proteomic markers[J].Clin Chim Acta,2013,421：17-30. 　
[7]　谢红,黄智勇,刘玉.肾炎康复片治疗肾小球肾炎的作用机理及疗效观察[J].河南中医学院学报,2005,20（5）：22-23. 　
[8]　徐疆,陈文玲.肾炎康复片治疗糖尿病肾病疗效观察[J].现代中西医结合杂志,2009,18（4）：374-375. 　
[9]　邓跃毅,陈以平,唐红,等.肾炎康复片治疗糖尿病肾病的疗效观察[J].中国中西医结合肾病杂志,2005,6（3）：151-153.
[10]　Moriguchi J,Inoue Y,Kamiyama S,et al.N-acetyl-beta-D-glucosaminidase（NAG） as the most sensitive marker of tubular dysfunction for monitoring residents in non-polluted areas[J].Toxicol Lett, 2009,190（1）：1-8.
[11]　郭振球.慢性肾脏病与微观证治学研究[J].河南中医,2007,27（1）：13-15.
[12]　Chen NK,Chong TW,Loh HL,et al.Negative regulatory respons-es to metabolically triggered inflammation impair renal epithe-lial immunity in diabetes mellitus[J].J Mol Med （Berl）,2013,91（5）：587-598.
[13]　马广蕊,金秀平.不同病程2型糖尿病患者血清C反应蛋白水平的比较[J].中国全科医学,2011,14（5）：494-496.
[14]　吴慧芳.2型糖尿病肾病患者超敏C反应蛋白的测定及分析[J].实用全科医学,2008,6（6）：594-595.
[15]　许敏玲,袁帅,丁德良.糖尿病肾病不同进展阶段的微炎症状态及其干预治疗研究[J].解剖学研究,2010,32（2）：121-125.

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备注/Memo

备注/Memo:
基金项目：天津市自然科学基金重点资助项目（13JCZDJC30500） 通信作者：单春艳,Email:chunyanshan@hotmail.com
更新日期/Last Update: 2014-05-20