[1]褚月颉,王鹏华.糖尿病伤口愈合不良的相关机制[J].国际内分泌代谢杂志,2014,(02):131-134.[doi:10.3760/cma.j.issn.1673-4157.2014.02.017]
　Chu Yuejie,Wang Penghua..Pathogenesis of impaired diabetic wound healing[J].International Journal of Endocrinology and Metabolism,2014,(02):131-134.[doi:10.3760/cma.j.issn.1673-4157.2014.02.017]
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糖尿病伤口愈合不良的相关机制()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
期数:
2014年02期
页码:
131-134
栏目:
综述
出版日期:
2014-04-30

文章信息/Info

Title:
Pathogenesis of impaired diabetic wound healing
作者:
褚月颉; 王鹏华
300070　天津医科大学代谢病医院足病科,卫生部激素与发育重点实验室
Author(s):
Chu Yuejie; Wang Penghua.
Department of Diabetic Foot,The Metabolic Disease Hospital,Tianjin Medical University,Key Laboratory of Hormones and Development,Ministry of Health,Tianjin 300070,China
关键词:
糖尿病; 伤口愈合; 生长因子; 炎症因子; 血管新生; 表观遗传学
Keywords:
Diabetic mellitus; Wound healing; Growth factor; Inflammatory cytokine; Angiogenesis; Epigenetic
DOI:
10.3760/cma.j.issn.1673-4157.2014.02.017
摘要:
糖尿病伤口愈合不良是临床常见并亟待解决的问题。其确切发病机制尚不清楚,可能是多种复杂因素共同作用的结果。目前研究发现其可能与高血糖引起的晚期糖基化终末产物蓄积、氧化应激增强和细胞凋亡增加有关。同时,各种生长因子缺乏,炎性反应因子异常表达以及与血管新生有关的细胞,如内皮祖细胞功能障碍和细胞外基质破坏,都会阻碍糖尿病伤口的愈合。另外,高血糖所引起的表观遗传学改变可能也是造成糖尿病伤口经久不愈的原因之一。对糖尿病伤口愈合不良机制的不断探索,将为加速糖尿病伤口愈合提供新的治疗靶点。
Abstract:
In diabetic patients,the impaired wound healing is a common clinical problem and needs to be solved urgently. Its exact pathogenesis is unclear. It is probably the result of joint action of many complex factors. Recent studies show that it may be associated with the accumulation of advanced glycation end products,the increased oxidative stress and cell apoptosis caused by hyperglycemia. Simultaneously,growth factors deficiency,abnormal expression of inflammatory cytokines,angiogenesis-related cells dysfunction （such as endothelial progenitor cell,and extracellular matrix destruction）would hinder the wound healing in diabetic patients. Furthermore,the epigenetic changes caused by hyperglycemia might also cause a prolonged wound healing in diabetic patients. Further studies about the pathogenesis of the impaired diabetic wound healing will provide new therapeutic targets for the improvement of diabetic wound healing.

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备注/Memo

备注/Memo:
基金项目：天津市应用基础及前沿技术研究计划项目（天津市自然科学基金重点项目）（10JCZDJC19800）；天津医科大学科学基金（2008KY17）；天津市卫生局科技基金（09KZ87）
更新日期/Last Update: 2014-03-20