[1]罗冬强,邵莹,潘凯瑶,等.间歇性禁食对超重及肥胖患者体重和代谢指标影响的网状荟萃分析[J].国际内分泌代谢杂志,2023,43(04):291-396.[doi:10.3760/cma.j.cn121383-20220111-01019]
　Luo Dongqiang,Shao Ying,Pan Kaiyao,et al.Net meta-analysis of intermittent fasting in improving body weight and metabolic parameters in overweight and obese patients[J].International Journal of Endocrinology and Metabolism,2023,43(04):291-396.[doi:10.3760/cma.j.cn121383-20220111-01019]
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间歇性禁食对超重及肥胖患者体重和代谢指标影响的网状荟萃分析()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
43
期数:
2023年04期
页码:
291-396
栏目:
论著
出版日期:
2023-07-20

文章信息/Info

Title:
Net meta-analysis of intermittent fasting in improving body weight and metabolic parameters in overweight and obese patients
作者:
罗冬强1; 2; 邵莹3; 潘凯瑶1; 2; 黄美婷1; 2; 刘峰4
1广州中医药大学,广州 510080; 2广东祈福医院,广州 511400; 3武汉轻工大学,武汉 430000; 4广州中医药大学第三附属医院,广州 510000
Author(s):
Luo Dongqiang1; 2;  Shao Ying3;  Pan Kaiyao1; 2;  Huang Meiting1; 2;  Liu Feng4
1Guangzhou University of Chinese Medicine, Guangzhou 510080, China; 2Guangdong Clifford Hospital, Guangzhou 511400, China; 3Wuhan Polytechnic University, Wuhan 430000, China; 4The Third Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510000
关键词:
间歇性禁食;  代谢指标;  肥胖;  网状荟萃分析
Keywords:
Intermittent fasting;  Metabolic indicators;  Obesity;  Net meta-analysis
DOI:
10.3760/cma.j.cn121383-20220111-01019
摘要:
目的 探讨不同间歇性禁食对超重、肥胖患者的临床疗效及优势。方法 通过检索中英文数据库间歇性禁食治疗超重、肥胖患者的随机对照试验,进行网状荟萃分析。结果 本研究共纳入18篇文献,网状荟萃分析结果显示:通过SUCRA排序,限时禁食(TRF)在改善体重指数、体重、腰围、脂肪重量以及脱落率指标上成为最佳干预措施的可能性最大,次之为隔日禁食(ADF); 对于总胆固醇、空腹血糖、胰岛素抵抗控制,ADF表现更佳,次之为TRF; 结合可信区间及两两对比分析,TRF在不同指标上并不劣于ADF,且在脱落率上优于ADF; 本研究结果无明显不一致性,但存在一定的小样本效应或发表偏倚。结论 相对于持续性能量限制饮食,TRF及ADF改善超重肥胖患者脱落率、肥胖及代谢指标效果更佳; 体重指数及脱落率指标上,TRF具有优于ADF的可能性,而对于腰围、体重、脂肪重量、空腹血糖、总胆固醇、胰岛素抵抗指标,TRF并不劣于ADF,因此,TRF更适合依从性较差的超重、肥胖人群,但仍需临床试验进一步证实。
Abstract:
Objective To investigate the clinical efficacy and advantages of different intermittent fasts in overweight or obese patients.Methods A net meta-analysis was performed by searching English and Chinese databases of randomized controlled trials of intermittent fasting for the treatment of overweight and obese patients.Results A total of 18 papers were included in this study, and the results of the reticulated Meta-analysis: by SUCRA ranking, time-restricted fasting(TRF)was the most likely to be the best intervention in terms of improving BMI, weight, waist circumference, fat weight, and shedding rate indicators, followed by alternate-day fasting(ADF); for total cholesterol, fasting glucose, and insulin resistance control, ADF performed better, followed by TRF. Combined with the confidence interval and two-comparison analysis, TRF was not inferior to ADF in different indicators and was better than ADF in shedding rate; the results of this study were not significantly inconsistent but there was some small sample effect or publication bias.Conclusion Compared with continuous energy-restricted diet, time-restricted fasting and alternate-day fasting are more effective in improving shedding rate, obesity and metabolic indexes in overweight and obese patients; for BMI and shedding rate indexes, time-restricted fasting is more likely than alternate-day fasting, while for waist circumference, body weight, fat weight, fasting glucose, total cholesterol and insulin resistance indexes, time-restricted fasting is not inferior to alternate-day fasting, therefore, time-restricted fasting is more suitable for overweight obese patients with poor compliance, but further confirmation in clinical trials is needed.

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备注/Memo

备注/Memo:
通信作者:刘峰,Email:lftcm@163.com
更新日期/Last Update: 2023-08-15