[1]罗天谊,孙咏琪,魏莹.生长激素对1型糖尿病合并生长迟缓儿童影响的研究进展[J].国际内分泌代谢杂志,2023,43(03):203-206.[doi:10.3760/cma.j.cn121383-20220629-06066]
　Luo Tianyi,Sun Yongqi,Wei Ying..Effect of growth hormone in children with type 1 diabetes complicated with growth retardation[J].International Journal of Endocrinology and Metabolism,2023,43(03):203-206.[doi:10.3760/cma.j.cn121383-20220629-06066]
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生长激素对1型糖尿病合并生长迟缓儿童影响的研究进展()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
43
期数:
2023年03期
页码:
203-206
栏目:
综述
出版日期:
2023-05-20

文章信息/Info

Title:
Effect of growth hormone in children with type 1 diabetes complicated with growth retardation
作者:
罗天谊; 孙咏琪; 魏莹
天津医科大学总医院儿科,天津 300052
Author(s):
Luo Tianyi;  Sun Yongqi;  Wei Ying.
Department of Pediatric, Tianjin Medical University General Hospital, Tianjin 300052, China
关键词:
生长激素;  胰岛素样生长因子1;  1型糖尿病;  生长迟缓;  儿童
Keywords:
Growth hormone;  Insulin-like growth factor 1;  type 1 diabetes mellitus;  Growth retardation;  Children
DOI:
10.3760/cma.j.cn121383-20220629-06066
摘要:
患有1型糖尿病的儿童与健康的同龄人相比,胰岛素样生长因子-1更低,更易合并生长迟缓。国际青少年糖尿病联盟在营养管理指南中指出,监测儿童线性增长是糖尿病管理的重要组成部分。但是,由于生长激素切点值不确定及担心生长激素、胰岛素两种拮抗激素联合应用血糖控制不佳,对于1型糖尿病合并生长迟缓的患儿,儿科医生常在应用生长激素/胰岛素样生长因子1、胰岛素联合治疗方面犹豫不决。该文综述了生长激素对1型糖尿病合并生长迟缓儿童各方面影响的研究进展,以期为生长激素/胰岛素样生长因子1治疗1型糖尿病合并生长迟缓患儿提供临床参考。
Abstract:
Children with type 1 diabetes have insulin-like growth factor 1 and are more likely to suffer from growth retardation than their healthy peers. The International Juvenile Diabetes Federation points out in the nutritional management guidelines that monitoring the linear growth of children is an important part of diabetes management. However, due to the uncertainty of the cut-point value of growth hormone and the fear of poor blood sugar control with the combination of growth hormone and insulin antagonistic hormones, pediatricians often hesitate to use the combination of growth hormone and insulin for children withtype 1 diabetes mellitus(T1DM)and growth retardation. This article reviews the research progress on the effects of rhGH/rhIGF-1 on various aspects of children with T1DM and growth retardation, in order to provide clinical reference for rhGH/rhIGF-1 therapy in children with T1DM and growth retardation.

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备注/Memo

备注/Memo:
通信作者:魏莹,Email:zzz_wy1@sina.com
基金项目:天津市科技计划项目(19KPHDRC00020); 天津市医学重点学科(专科)建设项目(TJYXZDXK-068C)
更新日期/Last Update: 2023-05-20