[1]李雪梅.miRNA在肿瘤糖代谢中的调节作用[J].国际内分泌代谢杂志,2023,43(02):109-112.[doi:10.3760/cma.j.cn121383-20211025-10054]
　Li Xuemei..The regulatory role of miRNA in tumor glucose metabolism[J].International Journal of Endocrinology and Metabolism,2023,43(02):109-112.[doi:10.3760/cma.j.cn121383-20211025-10054]
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miRNA在肿瘤糖代谢中的调节作用 ()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
43
期数:
2023年02期
页码:
109-112
栏目:
综述
出版日期:
2023-03-20

文章信息/Info

Title:
The regulatory role of miRNA in tumor glucose metabolism
作者:
李雪梅
天津医科大学朱宪彝纪念医院、天津市内分泌研究所、国家卫生健康委员会激素与发育重点实验室、天津市代谢性疾病重点实验室,天津 300134
Author(s):
Li Xuemei.
NHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory of Metabolic Diseases, Chu Hsien-I Memorial Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin 300134, China
关键词:
糖代谢;  微小RNA;  肿瘤
Keywords:
Glucose metabolism;  MicroRNA;  Tumor
DOI:
10.3760/cma.j.cn121383-20211025-10054
摘要:
代谢重编程是肿瘤发生的重要特征,其中糖代谢异常在肿瘤的发生和转移中扮演了重要角色,而微小RNA(micro RNA,miRNA)直接或间接参与肿瘤细胞糖代谢的调控。miRNAs通过对糖代谢关键酶、信号通路以及转录因子的正向或负向调节,改变肿瘤细胞糖代谢过程,进而对肿瘤细胞的生物学特性产生影响。一些临床前期研究已经观察到基于miRNA靶向治疗的安全性和有效性。因此,对miRNAs在肿瘤糖代谢中的调控作用进行综述,可能为肿瘤发病机制的研究和治疗提供新的方向。
Abstract:
Metabolic reprogramming is an important feature of tumorigenesis, and in this process abnormal glucose metabolism plays an important role in tumorigenesis and metastasis, while microRNA(miRNA)are involved in the regulation of glucose metabolism of tumor cells directly or indirectly. miRNAs change the process of glucose metabolism of tumor cells through positive or negative regulation of key enzymes, signal pathways and transcription factors of glucose metabolism, thus affecting the biological characteristics of tumor cells. Some preclinical studies have observed the safety and effectiveness of miRNA-based targeted therapy. A review of the regulatory role of miRNA in tumor glucose metabolism may provide new directions for the study of pathogenesis and treatment of tumor.

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备注/Memo

备注/Memo:
通信作者:李雪梅,Email:xmlixmli@163.com
更新日期/Last Update: 2023-04-15