[1]杨盛旻,朱惠娟,段炼.GIP/GIPR通路与神经内分泌肿瘤关系的研究进展[J].国际内分泌代谢杂志,2022,42(06):501-504.[doi:10.3760/cma.j.cn121383-20210704-07010]
 Yang Shengmin,Zhu Huijuan,Duan Lian..Recent progress in the relationship between GIP/GIPR signaling and neuroendocrine tumors[J].International Journal of Endocrinology and Metabolism,2022,42(06):501-504.[doi:10.3760/cma.j.cn121383-20210704-07010]
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GIP/GIPR通路与神经内分泌肿瘤关系的研究进展 ()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
42
期数:
2022年06期
页码:
501-504
栏目:
综述
出版日期:
2022-11-20

文章信息/Info

Title:
Recent progress in the relationship between GIP/GIPR signaling and neuroendocrine tumors
作者:
杨盛旻12朱惠娟1段炼1
1中国医学科学院,北京协和医学院,北京协和医院内分泌科,国家卫生健康委员会内分泌重点实验室,协和转化医学中心 100730; 2临床医学专业试点班,北京协和医学院,中国医学科学院 100730
Author(s):
Yang Shengmin12 Zhu Huijuan1 Duan Lian1.
1Department of Endocrinology,Translational Medicine Center, Key Laboratory of Endocrinology of National Health Commission, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing 100730, China; 24+4 Medical Doctor Program, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China
关键词:
葡萄糖依赖的促胰岛素多肽 葡萄糖依赖的促胰岛素多肽受体 神经内分泌肿瘤
Keywords:
Glucose-dependent insulinotropic polypeptide Glucose-dependent insulinotropic polypeptide receptor Neuroendocrine tumors
DOI:
10.3760/cma.j.cn121383-20210704-07010
摘要:
葡萄糖依赖性促胰岛素多肽(GIP)是一种可以促进餐后胰岛素分泌的肠促胰岛素。GIP及其受体(GIPR)与神经内分泌肿瘤(NETs)的病理机制及临床表现息息相关。GIP/GIPR通路的异常激活在食物依赖性库欣综合征、糖耐量试验中生长激素(GH)反常升高的肢端肥大症以及胃肠道NETs中最为典型。GIP与肾上腺皮质腺瘤及垂体GH腺瘤异位表达的GIPR结合后,促进相应激素分泌增加及细胞增殖。再者,部分生长抑素受体阴性的胃肠道NETs高表达GIPR,基于GIPR的示踪剂可准确定位此类NETs。深入了解GIP/GIPR在NETs中的病理机制及临床应用可为进一步研究和临床工作提供理论依据。
Abstract:
Glucose dependent insulinotropic polypeptide(GIP)is an incretin that promotes the postprandial secretion of insulin. GIP and its receptor(GIPR)are highly involved in the pathological and clinical manifestations of neuroendocrine tumors(NETs). In particular, GIP/GIPR coupling plays an active part in the development of food-dependent Cushing's syndrome, the paradoxical increase in GH level during oral glucose tolerance test in some acromegaly patients, and the imaging of gastrointestinal NETs. The binding of GIP with ectopically expressed GIPR in adrenal adenoma(or pituitary adenoma)promotes the excessive secretion of cortisol(or GH)and cell hyperplasia. Moreover, imaging via radiolabeled GIPR facilitates the precise localization of somatostatin receptor negative NETs. The recent research progress in the relation between the GIP/GIPR axis and NETs was reviewed, in order to provide suggestions for further research and guide the clinical practice in NETs treatment.

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备注/Memo

备注/Memo:
通信作者:段炼,Email: duanlianpumc@163.com
基金项目:中央高水平医院临床科研业务费资助(2022-PUMCH-A-155); 北京协和医学院2021年中央高校教育教学改革专项资金支持项目(2021zlgc0109)
更新日期/Last Update: 2022-12-01