参考文献/References:
[1] Hemmelgarn BR,Manns BJ,Lloyd A,et al.Relation between kidney function,proteinuria,and adverse outcomes[J].JAMA,2010,303(5):423-429.DOI:10.1001/jama.2010.39.
[2] Looker HC,Mauer M,Saulnier PJ,et al.Changes in albuminuria but not GFR are associated with early changes in kidney structure in type 2 diabetes[J].J Am Soc Nephrol,2019,30(6):1049-1059.DOI:10.1681/ASN.2018111166.
[3] Tong X,Yu Q,Ankawi G,et al.Insights into the Role of Renal Biopsy in Patients with T2DM:A Literature Review of Global Renal Biopsy Results[J].Diabetes Ther,2020,11(9):1983-1999.DOI:10.1007/s13300-020-00888-w.
[4] Wang JY,Yang JH,Xu J,et al.Renal tubular damage may contribute more to acute hyperglycemia induced kidney injury in non-diabetic conscious rats[J].J Diabetes Complications,2015,29(5):621-628.DOI:10.1016/j.jdiacomp.2015.04.014.
[5] Sharma SG,Bomback AS,Radhakrishnan J,et al.The modern spectrum of renal biopsy findings in patients with diabetes[J].Clin J Am Soc Nephrol,2013,8(10):1718-1724.DOI:10.2215/CJN.02510213.
[6] Ekinci EI,Jerums G,Skene A,et al.Renal structure in normoalbuminuric and albuminuric patients with type 2 diabetes and impaired renal function[J].Diabetes Care,2013,36(11):3620-3626.DOI:10.2337/dc12-2572.
[7] Maezawa Y,Takemoto M,Yokote K.Cell biology of diabetic nephropathy:roles of endothelial cells,tubulointerstitial cells and podocytes[J].J Diabetes Invest,2015,6(1):3-15.DOI:10.1111/jdi.12255.
[8] Zerbini G,Bonfanti R,Meschi F,et al.Persistent renal hypertrophy and faster decline of glomerular filtration rate precede the development of microalbuminuria in type 1 diabetes[J].Diabetes,2006,55(9):2620-2625.DOI:10.2337/db06-0592.
[9] Vallon V,Thomson SC.Renal function in diabetic disease models:the tubular system inthe pathophysiology of the diabetic kidney[J].Annu Rev Physiol,2012,74:351-375.DOI:10.1146/annurev-physiol-020911-153333.
[10] An Y,Xu F,Le W,et al.Renal histologic changes and the outcome in patients with diabetic nephropathy[J].Nephrol Dial Transplant,2015,30(2):257-266.DOI:10.1093/ndt/gfu250.
[11] Mise K,Hoshino J,Ueno T,et al.Clinical and pathological predictors of estimated GFR decline in patients with type 2 diabetes and overt proteinuric diabetic nephropathy[J].Diabetes Metab Res Rev,2015,31(6):572-581.DOI:10.1002/dmrr.2633.
[12] Vaidya VS,Niewczas MA,Ficociello LH,et al.Regression of microalbuminuria in type 1 diabetes is associated with lower levels of urinary tubular injury biomarkers,kidney injury molecule-1,and N-acetyl-β-D-glucosaminidase[J].Kidney Int,2011,79(4):464-470.DOI:10.1038/ki.2010.404.
[13] Nauta FL,Boertien WE,Bakker SJ,et al.Glomerular and tubular damage markers are elevated in patients with diabetes[J].Diabetes Care,2011,34(4):975-981.DOI:10.2337/dc10-1545.
[14] Comper WD.Albuminuria is controlled primarily by proximal tubules[J].Nat Rev Nephrol,2014,10(3):180.DOI:10.1038/nrneph.2013.58-c1.
[15] Wagner MC,Campos-Bilderback SB,Chowdhury M,et al.Proximal tubules have the capacity to regulate uptake of albumin[J].J Am Soc Nephrol,2016,27(2):482-494.DOI:10.1681/ASN.2014111107.
[16] Desideri S,Onions KL,Qiu Y,et al.A novel assay provides sensitive measurement of physiologically relevant changes in albumin permeability in isolated human and rodent glomeruli[J].Kidney Int,2018,93(5):1086-1097.DOI:10.1016/j.kint.2017.12.003.
[17] Russo LM,Sandoval RM,McKee M,et al.The normal kidney filters nephrotic levels of albumin retrieved by proximal tubule cells:retrieval is disrupted in nephrotic states[J].Kidney Int,2007,71(6):504-513.DOI:10.1038/sj.ki.5002041.
[18] Christensen EI,Birn H.Proteinuria:Tubular handling of albumin-degradation or salvation?[J].Nat Rev Nephrol,2013,9(12):700-702.DOI:10.1038/nrneph.2013.212.
[19] Tenten V,Menzel S,Kunter U,et al.Albumin is recycled from the primary urine by tubular transcytosis[J].J Am Soc Nephrol,2013,24(12):1966-1980.DOI:10.1681/ASN.2013010018.
[20] Ren Q,Weyer K,Rbaibi Y,et al.Distinct functions of megalin and cubilin receptors in recovery of normal and nephrotic levels of filtered albumin[J].Am J Physiol Renal Physiol,2020,318(5):F1284-F1294.DOI:10.1152/ajprenal.00030.2020.
[21] Grove KJ,Lareau NM,Voziyan PA,et al.Imaging mass spectrometry reveals direct albumin fragmentation within the diabetic kidney[J].Kidney Int,2018,94(2):292-302.DOI:10.1016/j.kint.2018.01.040.
[22] Tojo A,Onozato ML,Ha H,et al.Reduced albumin reabsorption in the proximal tubule of early-stage diabetic rats[J].Histochem Cell Biol,2001,116(3):269-276.DOI:10.1007/s004180100317.
[23] Peres GB,Juliano MA,Simo～es MJ,et al.Lysosomal enzymes are decreased in the kidney of diabetic rats[J].Biochim Biophys Acta,2013,1832(1):85-95.DOI:10.1016/j.bbadis.2012.09.011.
[24] Russo LM,Brammar GC,Jerums G,et al.The effect of ramipril on albumin excretion in diabetes and hypertension:the role of increased lysosomal activity and decreased transforming growth factor-beta expression[J].J Hypertens,2003,21(2):419-428.DOI:10.1097/00004872-200302000-00035.
[25] Russo LM,Sandoval RM,Campos SB,et al.Impaired tubular uptake explains albuminuria in early diabetic nephropathy[J].J Am Soc Nephrol,2009,20(3):489-494.DOI:10.1681/ASN.2008050503.
[26] Peruchetti DB,Silva-Aguiar RP,Siqueira GM,et al.High glucose reduces megalin-mediated albumin endocytosis in renal proximal tubule cells through protein kinase B O-GlcNAcylation[J].J Biol Chem,2018,293(29):11388-11400.DOI:10.1074/jbc.RA117.001337.
[27] Zhou L,Liu F,Huang XR,et al.Amelioration of albuminuria in ROCK1 knockout mice with streptozotocin-induced diabetic kidney disease[J].Am J Nephrol,2011,34(5):468-475.DOI:10.1159/000332040.
[28] Hall AM,Unwin RJ.The not so 'mighty chondrion':emergence of renal diseases due to mitochondrial dysfunction[J].Nephron Physiol,2007,105(1):1-10.DOI:10.1159/000096860.
[29] Navarro-González JF,Mora-Fernández C,Muros de Fuentes M,et al.Inflammatory molecules and pathways in the pathogenesis of diabetic nephropathy[J].Nat Rev Nephrol,2011,7(6):327-340.DOI:10.1038/nrneph.2011.51.
[30] Rosca MG,Vazquez EJ,Chen Q,et al.Oxidation of fatty acids is the source of increased mitochondrial reactive oxygen species production in kidney cortical tubules in early diabetes[J].Diabetes,2012,61(8):2074-2083.DOI:10.2337/db11-1437.
[31] Samikkannu T,Thomas JJ,Bhat GJ,et al.Acute effect of high glucose on long-term cell growth:a role for transient glucose increase in proximal tubule cell injury[J].Am J Physiol Renal Physiol,2006,291(1):F162-175.DOI:10.1152/ajprenal.00189.2005.
[32] Qiu YY,Tang LQ.Roles of the NLRP3 inflammasome in the pathogenesis of diabetic nephropathy[J].Pharmacol Res,2016,114:251-264.DOI:10.1016/j.phrs.2016.11.004.
[33] Wang S,Li Y,Fan J,et al.Interleukin-22 ameliorated renal injury and fibrosis in diabetic nephropathy through inhibition of NLRP3 inflammasome activation[J].Cell Death Dis,2017,8(7):e2937.DOI:10.1038/cddis.2017.292.
[34] Clavant SP,Forbes JM,Thallas V,et al.Reversible angiotensin II-mediated albuminuria in rat kidneys is dynamically associated with cytoskeletal organization[J].Nephron Physiol,2003,93(2):p51-60.DOI:10.1159/000068528.
[35] Feliers D,Kasinath BS.Mechanism of VEGF expression by high glucose in proximal tubule epithelial cells[J].Mol Cell Endocrinol,2010,314(1):136-142.DOI:10.1016/j.mce.2009.09.009.
[36] Tojo A,Onozato ML,Kurihara H,et al.Angiotensin II blockade restores albumin reabsorption in the proximal tubules of diabetic rats[J].Hypertens Res,2003,26(5):413-419.DOI:10.1291/hypres.26.413.
[37] Nilsson LM,Zhang L,Bondar A,et al.Prompt apoptotic response to high glucose in SGLT-expressing renal cells[J].Am J Physiol Renal Physiol,2019,316(5):F1078-F1089.DOI:10.1152/ajprenal.00615.2018.
[38] Zhang XQ,Dong JJ,Cai T,et al.High glucose induces apoptosis via upregulation of Bim expression in proximal tubule epithelial cells[J].Oncotarget,2017,8(15):24119-24129.DOI:10.18632/oncotarget.15491.
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