[1]胡欣 韦晓 孙胜禄 陈煜 刘超.胰岛β细胞去分化、再分化与转分化的调控与功能[J].国际内分泌代谢杂志,2022,42(01):36-40.[doi:10.3760/cma.j.cn121383-20201026-10030]
　Hu Xin,Wei Xiao,Sun Shenglu,et al.Regulation and function of β cell dedifferentiation, redifferentiation and transdifferentiation[J].International Journal of Endocrinology and Metabolism,2022,42(01):36-40.[doi:10.3760/cma.j.cn121383-20201026-10030]
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胰岛β细胞去分化、再分化与转分化的调控与功能()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
42
期数:
2022年01期
页码:
36-40
栏目:
综述
出版日期:
2022-01-20

文章信息/Info

Title:
Regulation and function of β cell dedifferentiation, redifferentiation and transdifferentiation
作者:
胡欣1 韦晓2 孙胜禄3 陈煜2 刘超1
1南京中医药大学附属中西医结合医院内分泌科 210028; 2江苏省中医药研究院瘿病证治重点研究室,南京 210028; 3南京中医药大学附属中西医结合医院放射科 210028
Author(s):
Hu Xin1;  Wei Xiao2;  Sun Shenglu3;  Chen Yu2;  Liu Chao1.
1Department of Endocrinology, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210028, China; 2Key Laboratory of TCM Syndrome & Treatment of Yingbing of State Administration of Traditional Chinese Medicine, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing 210028, China; 3Department of Radiology, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210028, China
关键词:
胰岛β细胞功能;  去分化;  再分化;  转分化
Keywords:
β cell function;  Dedifferentiation;  Redifferentiation;  Transdifferentiation
DOI:
10.3760/cma.j.cn121383-20201026-10030
摘要:
胰岛β细胞功能衰竭是2型糖尿病(T2DM)发生及进展的中心环节,β细胞去分化可能是导致β细胞数量下降及功能障碍的核心机制。预防β细胞去分化和(或)促进去分化细胞再分化为β细胞是T2DM治疗的关键策略。通过诱导胚胎干细胞或多潜能干细胞分化或β细胞增殖、再分化及转分化可促进β细胞数量或体积的增加。深入理解β细胞去分化、再分化及转分化的调控过程有助于维持β细胞稳态,从而为T2DM的治疗提供新思路。
Abstract:
β cell failure plays a crucial role in the pathogenesis of type 2 diabetes mellitus, and β cell dedifferentiation has been shown to be one of the main causes leading to decreased β cell mass and β cell dysfunction. Preventing β cell dedifferentiation and(or)increasing β cell redifferentiation is a critical way in the management of diabetes. Increased β-cell mass or volume could be achieved via differentiation of embryonic stem(ES)cells or pluripotent stem cells or through β-cell renewal, including proliferation, redifferentiation, and transdifferentiation. Understanding pancreatic β-cell dedifferentiation, dedifferentiation and transdifferentiation could provide important information on developing effective strategies to cure diabetes.

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相似文献/References:

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备注/Memo

备注/Memo:
通信作者:刘超,Email: liuchao@nfmcn.com
更新日期/Last Update: 2022-01-20