[1]迪丽清娜·迪力木拉提,张君宜,曲伸.肥胖对新型冠状病毒肺炎患者的影响[J].国际内分泌代谢杂志,2021,41(06):632-635.[doi:10.3760/cma.j.cn121383-20200706-07014]
　Diliqingna·Dilimulati,Zhang Junyi,Qu Shen..Effects of obesity on patients with COVID-19[J].International Journal of Endocrinology and Metabolism,2021,41(06):632-635.[doi:10.3760/cma.j.cn121383-20200706-07014]
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肥胖对新型冠状病毒肺炎患者的影响()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
41
期数:
2021年06期
页码:
632-635
栏目:
综述
出版日期:
2021-12-20

文章信息/Info

Title:
Effects of obesity on patients with COVID-19
作者:
迪丽清娜·迪力木拉提1; 张君宜1; 2; 曲伸1
1同济大学附属第十人民医院内分泌科 200072; 2南京医科大学 211166
Author(s):
Diliqingna·Dilimulati1;  Zhang Junyi1; 2;  Qu Shen1.
1Department of Endocrinology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200072, China; 2Nanjing Medical University, Nanjing 211166, China
关键词:
新型冠状病毒肺炎;  肥胖症;  体重指数;  肥胖悖论
Keywords:
COVID-19;  Obesity;  Body mass index;  Obesity paradox
DOI:
10.3760/cma.j.cn121383-20200706-07014
摘要:
2020年初,新型冠状病毒肺炎(COVID-19)席卷全球,主要累及老年人及慢性病人群,肥胖者也不例外。新型冠状病毒(SARS-CoV-2)感染住院者的数据分析结果表明,肥胖住院患者比其他住院患者预后更差。许多研究强调了肥胖在SARS-CoV-2感染中有重要影响。其主要作用机制可能包括影响病毒的传染性、增加人类血管紧张素转换酶2(ACE2)的表达、激活哺乳动物雷帕霉素靶蛋白(mTOR)通路、使免疫系统更易受损、加剧炎性反应。
Abstract:
The coronavirus disease 2019(COVID-19), which swept the world at the end of 2019, mainly affected the elderly and those with chronic diseases, not excepting obesity. The results of the analysis of the data in regard to the inpatients who infected severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)showed that inpatients with obesity had a worse prognosis than the rest of inpatients. Many studies have emphasized that obesity plays an important role in SARS-CoV-2 infection. The main mechanisms may include affecting the contagiousness of the virus, increasing the expression of human angiotensin-converting enzyme 2(ACE2), hyperactivating mammalian target of rapamycin(mTOR)pathway, making the immune system more vulnerable and enhancing inflammation.

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备注/Memo

备注/Memo:
基金项目:国家科技部重点研发计划(2018YFC1314100,2016YFC1305600); 国家自然科学基金(81970677); 同济大学“中央高校基本科研业务费专项资金”(22120190210); 上海市科委基金(19DZ1910200,18411951803,17DZ1910603)
通信作者:曲伸,Email:qushencn@hotmail.com
更新日期/Last Update: 2021-12-10