[1]涂萍,杨清,段鹏,等.江西省居民中国人内脏脂肪指数与糖代谢异常的相关性分析[J].国际内分泌代谢杂志,2021,41(06):606-611.[doi:10.3760/cma.j.cn121383-20210309-03023]
　Tu Ping,Yang Qing,Duan Peng,et al.Correlation analysis between Chinese visceral adiposity index and abnormal glucose metabolism among residents of Jiangxi province[J].International Journal of Endocrinology and Metabolism,2021,41(06):606-611.[doi:10.3760/cma.j.cn121383-20210309-03023]
点击复制

江西省居民中国人内脏脂肪指数与糖代谢异常的相关性分析()
分享到：

《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
41
期数:
2021年06期
页码:
606-611
栏目:
论著
出版日期:
2021-12-20

文章信息/Info

Title:
Correlation analysis between Chinese visceral adiposity index and abnormal glucose metabolism among residents of Jiangxi province
作者:
涂萍1; 杨清2; 段鹏1; 柳江1; 杨枝1; 万兵花1; 胡亚琦1; 李卫红2; 胡承3
1南昌市第三医院内分泌科 330009; 2江西中医药大学,南昌 330000; 3上海交通大学附属第六人民医院内分泌代谢科,上海市糖尿病研究所 200223
Author(s):
Tu Ping1;  Yang Qing2;  Duan Peng1;  Liu Jiang1;  Yang Zhi1;  Wan Binghua1;  Hu Yaqi1;  Li Weihong2;  Hu Cheng3.
1Department of Endocrinology, the Third Hospital of Nanchang, Nanchang 330009, China; 2Jiangxi University of Traditional Chinese Medicine, Nanchang 330000, China; 3 Department of Endocrinology and Metabolism, Shanghai Jiao
关键词:
中国人内脏脂肪指数;  糖代谢异常;  糖尿病前期;  糖尿病
Keywords:
Chinese visceral adiposity index;  Abnormal glucose metabolism;  Pre-diabetes;  Diabetes mellitus
DOI:
10.3760/cma.j.cn121383-20210309-03023
摘要:
目的 探究江西省居民中国人内脏脂肪指数(CVAI)与糖代谢异常患病的关系。方法 该研究基于2018年江西省成人慢性病及其危险因素监测调查结果,用多元logistic回归分析,分析不同性别、不同CVAI水平(四分位数分组)纳入者与糖尿病前期、糖尿病患病的关系。结果 糖耐量正常组2 996名,糖尿病前期组1 097名,糖尿病组697例。3组研究对象中不同CVAI水平组居民糖代谢异常患病分布差异有统计学意义(P<0.001),且糖尿病前期和糖尿病患病率均随CVAI的增长呈上升趋势,且女性较男性增长明显。多元logistic回归分析结果表明,糖尿病前期和糖尿病的患病率随着CVAI水平的升高而增加(P均<0.05),在校正年龄后,CVAI仍与糖代谢状态显著相关,其中男性CVAI最高和最低四分位数之间的比较中,糖尿病前期和糖尿病的优势比(95% CI)分别为2.40(1.66～3.46)、2.76(1.83～4.16),女性CVAI最高和最低四分位数之间的比较中,糖尿病前期和糖尿病的OR(95% CI)分别为4.81(3.45～6.72)、7.38(4.84～11.26),差异有统计学意义(P均<0.05); 再校正相关混杂因素后,女性CVAI最高和最低四分位数之间的比较中,糖尿病前期和糖尿病的OR(95% CI)分别为2.23(1.14～4.38)、3.87(1.73～8.61),差异有统计学意义(P均<0.05)。结论 CVAI与糖代谢异常密切相关,且女性较男性显著。CVAI值越大,糖尿病前期和糖尿病患病风险越高,对糖代谢异常患病的预测有重要价值。
Abstract:
Objective To investigate the relationship between Chinese visceral adiposity index(CVAI)and abnormal glucose metabolism among residents of Jiangxi province.Methods This study was based on the survey results of adult chronic diseases and their risk factors in Jiangxi province in 2018.Multivariate logistic regression analysis was used to analyze the relationship between different genders, different CVAI levels(quartile grouping)and prediabetes and diabetes.Results There were 2 996 patients in the normal glucose tolerance group, 1 097 patients in the pre-diabetes group, and 697 patients in the diabetes group. In the 3 groups,there was a statistically significant difference in the distribution of abnormal glucose metabolism among residents of different CVAI level groups(P<0.001), and the pre-diabetes and diabetes prevalence rates both increased with the increase of CVAI, and the increase in women was more obvious than that of men. The results of multivariate logistic regression analysis showed that with the increase of CVAI level, the pre-diabetes and diabetes prevalence rates also increased(all P<0.05). After adjusting for age, CVAI was still significantly correlated with glucose metabolism status, and male CVAI was the highest in the comparison with the lowest quartile, the OR(95% CI)of prediabetes and diabetes were 2.40(1.66-3.46)and 2.76(1.83-4.16), respectively; In the comparison between the highest and lowest quartile of female CVAI, the OR(95% CI)of prediabetes and diabetes were 4.81(3.45-6.72)and 7.38(4.84-11.26), respectively, and the differences were statistically significant(all P<0.05); After correcting for related confounding factors, the comparison between the highest and lowest quartile of female CVAI, the OR of prediabetes and diabetes(95% CI)were 2.23(1.14-4.38)and 3.87(1.73-8.61), respectively, the differences were statistically significant(all P<0.05).Conclusion CVAI is closely related to abnormal blood glucose metabolism, and it is more significant in women than men. The greater the CVAI value, the higher the risk of pre-diabetes and diabetes, and it has important clinical value for the prevention and diagnosis of abnormal glucose metabolism.

参考文献/References:

[1] Hwang YC,Hayashi T,Fujimoto WY,et al.Visceral abdominal fat accumulation predicts the conversion of metabolically healthy obese subjects to an unhealthy phenotype[J].Int J Obes(Lond),2015,39(9):1365-1370.DOI:10.1038/ijo.2015.75.
[2] Oh JY,Sung YA,Lee HJ.The visceral adiposity index as a predictor of insulin resistance in young women with polycystic ovary syndrome[J].Obesity(Silver Spring),2013,21(8):1690-1694.DOI:10.1002/oby.20096.
[3] 张玲敏,郑晓雅,谢欣,等.中国内脏脂肪指数对中国成人生长激素缺乏患者胰岛素抵抗的评估作用[J].解放军医学杂志,2019,44(11):942-947.DOI:10.11855/j.issn.0577-7402.2019.11.08.
[4] Xia MF,Chen Y,Lin HD,et al.A indicator of visceral adipose dysfunction to evaluate metabolic health in adult Chinese[J].Sci Rep,2016,6:38214.DOI:10.1038/srep38214.
[5] Wu J,Gong L,Li Q,et al.A novel visceral adiposity index for prediction of type 2 diabetes and pre-diabetes in Chinese adults:a 5-year prospective study[J].Sci Rep,2017,7(1):13784.DOI:10.1038/s41598-017-14251-w.
[6] Wei J,Liu X,Xue H,et al.Comparisons of visceral adiposity index,body shape index,body mass index and waist circumference and their associations with diabetes mellitus in adults[J].Nutrients,2019,11(7):1580.DOI:10.3390/nu11071580.
[7] 涂萍,李卫红,段鹏,等.江西省成人脂质蓄积指数与糖代谢异常患病的相关性分析[J].中华糖尿病杂志,2021,13(2):169-174.DOI:10.3760/cma.j.cn115791-20200607-00351.
[8] 涂萍,胡亚琦,胡承,等.江西省成人糖尿病患病率调查及与血脂异常的相关性分析[J].中华糖尿病杂志,2019.11(12):793-798.DOI:10.3760/cma.j.issn.1674-5809.2019.12.005.
[9] Amato MC,Giordano C,Galia M,et al.Visceral adiposity index:a reliable indicator of visceral fat function associated with cardiometabolic risk[J].Diabetes Care,2010,33(4):920-922.DOI:10.2337/dc09-1825.
[10] 中华医学会糖尿病学分会.中国2型糖尿病防治指南(2017年版)[J].中华糖尿病杂志,2018,10(1):467.DOI:10.3760/cma.j.issn.16745809.2018.01.003.
[11] Cheng CH,Ho CC,Yang CF,et al.Waist-to-hip ratio is a better anthropometric index than body mass index for predicting the risk of type 2 diabetes in Taiwanese population[J].Nutr Res,2010,30(9):585-593.DOI:10.1016/j.nutres.2010.08.007.
[12] Ashwell M,Gunn P,Gibson S.Waist-to-height ratio is a better screening tool than waist circumference and BMI for adult cardiometabolic risk factors:systematic review and metaanalysis[J].Obes Rev,2012,13(3):275-286.DOI:10.1111/j.1467-789X.2011.00952.x.
[13] Bozorgmanesh M,Hadaegh F,Azizi F.Diabetes prediction,lipid accumulation product,and adiposity measures; 6-year follow-up:Tehran lipid and glucose study[J].Lipids Health Dis,2010,9:45.DOI:10.1186/1476-511X-9-45.
[14] Nascimento-Ferreira MV,Rendo-Urteaga T,Vilanova-Campelo RC,et al.The lipid accumulation product is a powerful tool to predict metabolic syndrome in undiagnosed Brazilian adults[J].Clin Nutr,2017,36(6):1693-1700.DOI:10.1016/j.clnu.2016.12.020.
[15] Kavaric N,Klisic A,Ninic A.Are visceral adiposity index and lipid accumulation product reliable indices for metabolic disturbances in patients with type 2 diabetes mellitus?[J].J Clin Lab Anal,2018,32:e22283.DOI:10.1002/jcla.22283.
[16] Wakabayashi I,Daimon T.The "cardiometabolic index" as a new marker determined by adiposity and blood lipids for discrimination of diabetes mellitus[J].Clin Chim Acta,2015,438:274-278.DOI:10.1016/j.cca.2014.08.042.
[17] Shi WR,Wang HY,Chen S,et al.Estimate of prevalent diabetes from cardiometabolic index in general Chinese population:a community-based study[J].Lipids Health Dis,2018,17(1):236.DOI:10.1186/s12944-018-0886-2.
[18] Wang Y,He S,He J,et al.Predictive value of visceral adiposity index for type 2 diabetes mellitus:a 15-year prospective cohort study[J].Herz,2015,40 Suppl 3:277-281.DOI:10.1007/s00059-014-4175-1.
[19] Gu D,Ding Y,Zhao Y,Qu Q.Visceral adiposity index was a useful predictor of prediabetes[J].Exp Clin Endocrinol Diabetes,2018,126(10):596-603.DOI:10.1055/s-0043-120440.
[20] Yang Y,Feng Y,Ma X,et al.Visceral adiposity index and insulin secretion and action in first-degree relatives of subjects with type 2 diabetes[J].Diabetes Metab Res Rev,2015,31(3):315-321.DOI:10.1002/dmrr.2615.
[21] Janghorbani M,Amini M.The visceral adiposity index in comparison with easily measurable anthropometric markers did not improve prediction of diabetes[J].Can J Diabetes,2016,40(5):393-398.DOI:10.1016/j.jcjd.2016.02.008.
[22] 张书平,张晓静,汪志红,等.重庆某社区中国人内脏脂肪指数与2型糖尿病发病的相关性分析[J].解放军医学杂志,2020,45(7):725-729.DOI:10.11855/j.issn.0577-7402.2020.07.08.

相似文献/References:

[1]张超,王先令,陈予龙,等.136例POEMS综合征患者内分泌代谢异常的临床特点回顾性分析[J].国际内分泌代谢杂志,2021,41(01):38.[doi:10.3760/cma.j.cn121383-20200413-04035]
　Zhang Chao,Wang Xianling,Chen Yulong,et al.Retrospective analysis of the clinical characteristics of endocrine-metabolic abnormalities in 136 patients with POEMS syndrome[J].International Journal of Endocrinology and Metabolism,2021,41(06):38.[doi:10.3760/cma.j.cn121383-20200413-04035]

备注/Memo

备注/Memo:
基金项目:国家自然科学基金(81760153); 江西省重点研发计划项目(20171ACH80002)
通信作者:涂萍,Email:tuping8877@126.com
更新日期/Last Update: 2021-12-10