[1]徐婷,吴丹,胡翠宁,等.甲状腺乳头状癌的淋巴结转移预测模型建立[J].国际内分泌代谢杂志,2021,41(06):596-600,611.[doi:10.3760/cma.j.cn121383-20200826-08042]
　Xu Ting,Wu Dan,Hu Cuining,et al.Construction of a risk-scoring model to predict lymph node metastasis in papillary thyroid carcinoma[J].International Journal of Endocrinology and Metabolism,2021,41(06):596-600,611.[doi:10.3760/cma.j.cn121383-20200826-08042]
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甲状腺乳头状癌的淋巴结转移预测模型建立()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
41
期数:
2021年06期
页码:
596-600,611
栏目:
论著
出版日期:
2021-12-20

文章信息/Info

Title:
Construction of a risk-scoring model to predict lymph node metastasis in papillary thyroid carcinoma
作者:
徐婷1; 吴丹1; 胡翠宁1; 刘翠萍2; 唐伟1
1南京医科大学附属老年医院内分泌科 210024; 2南京医科大学第一附属医院公共平台实验室 210000
Author(s):
Xu Ting1;  Wu Dan1;  Hu Cuining1;  Liu Cuiping2;  Tang Wei1.
1Department of Endocrinology, the Affiliated Geriatric Hospital of Nanjing Medical University, Nanjing 210024, China; 2Public Laboratory Platform, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210000, China
关键词:
甲状腺乳头状癌;  淋巴结转移;  预测模型
Keywords:
Papillary thyroid carcinoma;  Lymph node metastasis;  Prediction model
DOI:
10.3760/cma.j.cn121383-20200826-08042
摘要:
目的 建立甲状腺乳头状癌(PTC)淋巴结转移预测模型。方法 选取南京医科大学第一附属医院普外科行甲状腺切除术及颈部淋巴结清扫术的PTC患者139例,收集其术前临床特征、实验室检查、高分辨超声及术后病理、基因等资料,利用单因素、多因素分析筛选独立预测淋巴结转移的变量建立模型,构建受试者工作特征(ROC)曲线评估模型的预测价值。结果 79.9%(111例)患者病理证实存在淋巴结转移。二分类logistic回归分析结果示超声可疑转移性淋巴结、结节直径为独立预测指标,根据OR值分别赋分为14分、1分。模型的敏感性、特异性、曲线下面积分别为81.1%、82.1%、0.864。结论 超声可疑转移性淋巴结以及结节直径为PTC淋巴结转移的独立预测指标,构建的淋巴结转移预测模型具有较高的预测价值。
Abstract:
Objective To construct a risk-scoring model to predict lymph node metastasis in papillary thyroid carcinoma(PTC).Methods A total of 139 patients with PTC who received thyroidectomy and radical neck dissection in the Department of General Surgery, the First Affiliated Hospital of Nanjing Medical University were enrolled in this study. The demographic features, laboratory test results, high-resolution ultrasound results, pathological findings and gene test results were retrospectively collected. Univariate and multivariate analysis were performed to select the independent variables to predict lymph node metastasis. Receiver operating characteristic(ROC)curves were conducted to evaluate the diagnostic performance.Results Lymph node metastasis existed in 111(79.9%)patients by histopathology. Binary logistic regression analysis showed that only two variables could independently predict lymph node metastasis including suspicious lymph node on ultrasonography and nodule diameter. These two variables were assigned with 14 and 1 scores based on OR values, respectively. The sensitivity, specificity and AUC of the constructed model were 81.1%, 82.1% and 0.864, respectively.Conclusion A risk-scoring model that consist of two variables including suspicious lymph node on ultrasonography and nodule diameter was constructed to predict lymph node metastasis of papillary thyroid cancer with excellent prediction performance.

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备注/Memo

备注/Memo:
基金项目:江苏卫生健康职业学院院级科研项目(JKB201722)
通信作者:唐伟,Email: drtangwei@njmu.edu.cn
更新日期/Last Update: 2021-12-10