[1]时磊,王莉,梁声茹,等.青中年时期体重状态变化与中老年时期高血压的关系[J].国际内分泌代谢杂志,2021,41(02):100-104.[doi:10.3760/cma.j.cn121383-20200625-06078]
　Shi Lei,Wang Li,Liang Shengru,et al.Relationship between changes of body weight status in young and middle-aged and hypertension in middle-aged and elderly people[J].International Journal of Endocrinology and Metabolism,2021,41(02):100-104.[doi:10.3760/cma.j.cn121383-20200625-06078]
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青中年时期体重状态变化与中老年时期高血压的关系()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
41
期数:
2021年02期
页码:
100-104
栏目:
论著
出版日期:
2021-03-20

文章信息/Info

Title:
Relationship between changes of body weight status in young and middle-aged and hypertension in middle-aged and elderly people
作者:
时磊; 王莉; 梁声茹; 鱼馨文; 李乔岳; 苟嘉琨; 姬秋和
空军军医大学西京医院内分泌科,西安 710032
Author(s):
Shi Lei;  Wang Li;  Liang Shengru;  Yu Xinwen;  Li Qiaoyue;  Gou Jiakun;  Ji Qiuhe.
Department of Endocrinology, Xijing Hospital, The Military Medical University of Air Force, Xi'an 710032, China
关键词:
高血压;  超重;  肥胖;  体重变化
Keywords:
Hypertension;  Overweight;  Obesity;  Weight change
DOI:
10.3760/cma.j.cn121383-20200625-06078
摘要:
目的 探讨青年及中年时期超重后的体重状态变化及减重比与中老年高血压患病风险的关系。方法 选取中国糖尿病和代谢紊乱研究中年龄40～79岁的人群。减重比定义为(最大体重-目前体重)/最大体重。采用多因素logistic回归分析,分别探讨青年及中年超重后的体重状态变化及减重比与高血压的关系。结果 共19 823人纳入分析,共7 623人诊断为高血压。(1)与正常体重组[最大体重指数(MAXBMI)及体重指数(BMI)均在18.5～23.9 kg/m2]相比,青年时期持续超重(MAXBMI及BMI≥ 24.0 kg/m2,18岁≤最大体重年龄<40岁)及中年时期持续超重(MAXBMI及BMI ≥24.0 kg/m2,40岁≤最大体重年龄<60岁)高血压患病风险的OR(95% CI)分别为2.66(2.38～2.96)和2.79(2.56～3.03),青年时期既往超重(MAXBMI≥24.0 kg/m2,18.5 kg/m2≤BMI<24.0 kg/m2,18岁≤最大体重年龄<40岁)及中年时期既往超重(MAXBMI≥24.0 kg/m2,18.5 kg/m2≤BMI<24.0 kg/m2,40岁≤最大体重年龄<60岁)高血压患病风险的OR(95% CI)分别为1.20(1.04～1.37)和1.58(1.40～1.78)。(2)正常体重(18.5 kg/m2≤MAXBMI<24.0 kg/m2)及超重(MAXBMI≥ 24.0kg/m2)人群中,与减重比<5%相比,减重比≥5%与高血压患病风险降低相关。结论 青年及中年时期的超重与中老年高血压的患病风险增加密切相关,与目前BMI不相关。最大体重减轻≥5%与高血压患病风险降低密切相关,与MAXBMI不相关。
Abstract:
Objective To investigate the relationship between changes of weight status after becoming overweight in young adults and middle-aged and weight loss ratio and the risk of hypertension in middle-aged and elderly population.Methods Participants aged 40-79 years old were selected from China National Diabetes and Metabolic Disorders Survey. Weight loss ratio was defined as(maximum weight-current weight)/maximum weight. The association between changes of weight status after becoming overweight in young adults and middle-aged and weight loss ratio and the risk of hypertension was examined by using multivariate logistic regression. Results A total of 7 623 cases of hypertension were diagnosed among 19 823 study participants.(1)Compared with normal weight group(18.5 kg/m2≤both MAXBMI and BMI<24.0 kg/m2), the OR(95% CI)of hypertension for continuous overweight group from young adults(both MAXBMI and BMI≥24.0 kg/m2, 18 years≤age of maximum weight<40 years), continuous overweight group from middle-aged(both MAXBMI and BMI≥24.0 kg/m2, 40 years≤age of maximum weight<60 years)were 2.66(2.38-2.96)and 2.79(2.56-3.03), and the OR(95% CI)for past overweight from young adults(MAXBMI ≥24.0 kg/m2, 18.5 kg/m2≤BMI<24.0 kg/m2, 18 years ≤ age of maximum weight<40 years), past overweight from middle-aged(MAXBMI≥24.0 kg/m2, 18.5 kg/m2≤BMI<24.0 kg/m2, 40 years≤age of maximum weight<60 years)were 1.20(1.04-1.37)and 1.58(1.40-1.78).(2)Compared with weight loss ratio<5%,weight loss ratio ≥5% was associated with decreased risk of hypertension in normal weight(18.5 kg/m2≤MAXBMI<24.0 kg/m2)and overweight(MAXBMI≥24.0 kg/m2)population.Conclusion Overweight in young adults and middle-aged is associated with increased risk of hypertension in middle-aged and aged population regardless of current BMI. Weight loss of 5% or more from maximum body weight may be a protective factor against hypertension regardless of MAXBMI.

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备注/Memo

备注/Memo:
通信作者:姬秋和,Email:jqiuhe@fmmu.edu.cn 基金项目:国家重点研发计划(2017YFC1309803); 陕西省重点研发计划(2017ZDCXLSF0201)
更新日期/Last Update: 2021-03-20