[1]张玥,张慧娟.铁代谢与糖尿病早期微血管病变的相关性研究[J].国际内分泌代谢杂志,2021,41(01):44-47.[doi:10.3760/cma.j.cn121383-20200411-04022]
　Zhang Yue,Zhang Huijuan..Correlation between iron metabolism and early diabetic microangiopathy[J].International Journal of Endocrinology and Metabolism,2021,41(01):44-47.[doi:10.3760/cma.j.cn121383-20200411-04022]
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铁代谢与糖尿病早期微血管病变的相关性研究()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
41
期数:
2021年01期
页码:
44-47
栏目:
论著
出版日期:
2021-01-20

文章信息/Info

Title:
Correlation between iron metabolism and early diabetic microangiopathy
作者:
张玥; 张慧娟
哈尔滨医科大学附属第一医院内分泌科 150000
Author(s):
Zhang Yue;  Zhang Huijuan.
Department of Endocrinology, the First Affiliated Hospital of Harbin Medical University, Harbin 150000, China
关键词:
血清铁;  非增殖期糖尿病视网膜病变;  早期糖尿病肾病
Keywords:
Serum iron;  Nonproliferative diabetic retinopathy;  Early diabetic nephropathy
DOI:
10.3760/cma.j.cn121383-20200411-04022
摘要:
目的 评估铁代谢相关指标在2型糖尿病早期微血管并发症中的作用。方法 收集2019年1月至12月就诊于哈尔滨医科大学附属第一医院内分泌科的2型糖尿病患者作为研究对象,共计141例。单纯2型糖尿病(T2DM)患者60例为T2DM组,非增殖期糖尿病视网膜病变(NPDR)患者47例为NPDR组,早期糖尿病肾病(EDN)患者34例为EDN组。检测3组患者血清铁、铁蛋白以及空腹血糖等生化指标。Logistic回归分析法分析血清铁与NPDR和EDN发生的关系。结果 NPDR组[(16.22±5.06)μmol/L]和EDN组[(15.71±4.15)μmol/L]血清铁水平显著低于T2DM组[(18.38±5.91)μmol/L]。NPDR组和EDN组与T2DM组相比,病程、甘油三酯、血肌酐和肾小球滤过率等指标有显著的统计学意义,高血压与糖尿病肾病发生密切相关(P<0.05)。Logistic回归分析显示,血清铁是NPDR和EDN发生的保护性因素(OR=0.925,95% CI:0.857～0.998,P<0.05; OR=0.899,95% CI:0.818～0.988,P<0.05),血肌酐和病程是NPDR发生的危险因素(OR=1.093,95% CI:1.027～1.160,P<0.05; OR=1.044,95% CI:1.014～1.075,P<0.05)。结论 血清铁是糖尿病早期微血管并发症发生的保护性因素。
Abstract:
Objective To evaluate the effects of iron metabolism-related indicators on mild microvascular complications in type 2 diabetes.Methods A total of 141 patients with type 2 diabetes who attended in the Department of Endocrinology, the First Affiliated Hospital of Harbin Medical University from January to December 2019 were collected. A total of 60 patients with simple type 2 diabetes mellitus(T2DM)were selected as the T2DM group, 47 patients with nonproliferative diabetic retinopathy(NPDR)as the NPDR group, and 34 patients with early diabetic nephropathy(EDN)as the EDN group. The levels of serum iron, ferritin and fasting blood glucose were measured. Logistic regression analysis was used to analyze the relationship between serum iron and the occurrence of NPDR and EDN.Results The serum iron level in the NPDR group [(16.22±5.06)μmol/L] or the EDN group [(15.71±4.15)μmol/L] was lower than that in the simple T2DM group [(18.38±5.91)μmol/L](P<0.05). Compared with simple T2DM group, NPDR group and EDN group had statistically significant differences in disease course, triacylglycerol, glomerular filtration rate and creatinine, and hypertension was associated with the occurrence of diabetic nephropathy(P<0.05). Logistic regression analysis showed that serum iron was a protective factor for the occurrence of NPDR and EDN(OR=0.925, 95% CI: 0.857-0.998, P<0.05; OR=0.899, 95% CI: 0.818-0.988, P<0.05), whereas blood creatinine and course of disease were risk factors for the occurrence of NPDR(OR=1.093, 95% CI: 1.027-1.160, P<0.05; OR=1.044, 95% CI: 1.014-1.075, P<0.05). Conclusion Serum iron is a protective factor for early microvascular complications in T2DM.

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相似文献/References:

[1]张玥 张慧娟.铁代谢与糖尿病及其并发症的关系[J].国际内分泌代谢杂志,2020,40(02):117.[doi:10.3760/cma.j.issn.1673-4157.2020.02.011]
　Zhang Yue,Zhang Huijuan.Relationship between iron metabolism, diabetes mellitus and its complications[J].International Journal of Endocrinology and Metabolism,2020,40(01):117.[doi:10.3760/cma.j.issn.1673-4157.2020.02.011]

备注/Memo

备注/Memo:
通信作者:张慧娟,Email:hydzhj@126.com 基金项目:黑龙江省自然科学基金(H2016040)
更新日期/Last Update: 2021-01-20