[1]冯周琴,邵加庆,叶小珍.眼眶成纤维细胞异常脂肪分化与甲状腺相关性眼病关系的研究进展[J].国际内分泌代谢杂志,2021,41(01):15-19.[doi:10.3760/cma.j.cn121383-20200508-05011]
 Feng Zhouqin,Shao Jiaqing,Ye Xiaozhen..Abnormal adipogenesis originated from orbital fibroblasts in thyroid-associated ophthalmopathy[J].International Journal of Endocrinology and Metabolism,2021,41(01):15-19.[doi:10.3760/cma.j.cn121383-20200508-05011]
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眼眶成纤维细胞异常脂肪分化与甲状腺相关性眼病关系的研究进展()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
41
期数:
2021年01期
页码:
15-19
栏目:
甲状腺疾病专题
出版日期:
2021-01-20

文章信息/Info

Title:
Abnormal adipogenesis originated from orbital fibroblasts in thyroid-associated ophthalmopathy
作者:
冯周琴邵加庆叶小珍
南方医科大学第一临床医学院东部战区总医院内分泌科,南京 210000
Author(s):
Feng Zhouqin Shao Jiaqing Ye Xiaozhen.
Department of Endocrinology, General Hospital of Eastern Theater Command, the First School of Clinical Medicine, Southern Medical University, Nanjing 210000, China
关键词:
甲状腺相关性眼病 眼眶成纤维细胞 脂肪分化
Keywords:
Thyroid-associated ophthalmopathy Orbital fibroblasts Adipogenisis
DOI:
10.3760/cma.j.cn121383-20200508-05011
摘要:
甲状腺相关性眼病也称为Graves眼病(Graves' ophthalmopathy,GO),是一种发病机制尚未完全阐明、累及眼眶组织的自身免疫炎性疾病。突眼是该病最常见、也是最难缓解的症状,目前认为其主要与透明质酸沉积、眼外肌增粗、脂肪组织重塑等致眼眶内容物增加有关。其中,眼眶内脂肪组织的增多似乎与突眼关系更为紧密。眼眶成纤维细胞(orbital fibroblasts,OF)中的Thy1-亚型可以分化为脂肪细胞。OF具有分化为脂肪细胞的潜能,影响该分化过程的因素可能涉及信号转导通路的调节。综述GO发病过程中OF的脂肪分化异常,深入了解影响OF分化为脂肪细胞的机制,早期干预该分化过程,为GO治疗提供新的思路和切入点。
Abstract:
Thyroid-associated ophthalmopathy, also named Graves' ophthalmopathy(GO), is an autoimmune inflammatory disease involved in orbital tissue whose pathogenesis has not been fully elucidated. As the most common and difficultly relieved symptom clinically, proptosis is currently believed caused by the increase of orbital contents, such as hyaluronic acid deposition, extraocular muscle thickening and adipose tissue remodeling. Among them, the expansion of the orbital adipose tissue seems to relate closer to it. Thy1- subtypes in orbital fibroblasts(OF)can differentiate into adipocytes. OF has the potential to differentiate into adipocytes, and the factors affecting the differentiation process may involve in the regulation of signal transduction pathways. Abnormal adipogenesis originated from orbital fibroblasts in GO was reviewed to further understand the adipogenic mechanism, and to intervene it at an early stage, so as to provide new ideas and new action sites for treating GO.

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备注/Memo

备注/Memo:
通信作者:叶小珍,Email: yiyiye520@126.com
更新日期/Last Update: 2021-01-20