[1]张玥 张慧娟.铁代谢与糖尿病及其并发症的关系[J].国际内分泌代谢杂志,2020,40(02):117-120.[doi:10.3760/cma.j.issn.1673-4157.2020.02.011]
　Zhang Yue,Zhang Huijuan.Relationship between iron metabolism, diabetes mellitus and its complications[J].International Journal of Endocrinology and Metabolism,2020,40(02):117-120.[doi:10.3760/cma.j.issn.1673-4157.2020.02.011]
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铁代谢与糖尿病及其并发症的关系()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
40
期数:
2020年02期
页码:
117-120
栏目:
基础研究
出版日期:
2020-03-20

文章信息/Info

Title:
Relationship between iron metabolism, diabetes mellitus and its complications
作者:
张玥 张慧娟
哈尔滨医科大学附属第一医院内分泌科 150001
Author(s):
Zhang Yue;  Zhang Huijuan
Department of Endocrinology, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China
关键词:
血清铁;  铁蛋白;  糖尿病;  糖尿病并发症
Keywords:
Serum iron;  Ferritin;  Diabetes mellitus;  Diabetes complications
DOI:
10.3760/cma.j.issn.1673-4157.2020.02.011
摘要:
铁是生命活动中重要的微量元素之一。铁代谢稳态对其发挥生理功能具有重要意义。然而目前较多研究表明,铁代谢异常导致的铁过载是引起糖尿病的原因之一。体内铁过载会诱导氧化应激、炎性反应增强,引起细胞损伤、胰岛素抵抗及糖脂代谢紊乱,促使糖尿病及其并发症的发生。目前国内外研究表明,铁代谢的相关指标参与糖尿病及其并发症的发生、发展,故铁代谢的干预可能在未来糖尿病及其并发症的治疗中具有重要意义。
Abstract:
Iron is one of the important trace elements in life activities. The iron homeostasis plays an important role in its physiological function. However, more studies have shown that iron overload caused by abnormal iron metabolism is one of the causes of diabetes. Iron overload in the body can induce oxidative stress and inflammatory response, causing cell damage, insulin resistance and disorders of glycolipid metabolism to promote diabetes and its complications.Studies at home and abroad show that the related indicators of iron metabolism are involved in the development of diabetes and its complications. So the intervention of iron metabolism may be significant in the treatment of diabetes and its complications in the future.

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备注/Memo

备注/Memo:
通信作者:张慧娟,Email:hydzhj@126.com
Corresponding author: Zhang Huijuan, Email:hydzhj@126.com
更新日期/Last Update: 2020-03-20