[1]周茜,狄红杰,刘超,等.白细胞介素-18在糖尿病肾病中的介导作用[J].国际内分泌代谢杂志,2020,40(05):347-350.[doi:10.3760/cma.j.cn121383-20191210-12034]
　Zhou Qian,Di Hongjie,Liu Chao,et al.Intermediate role of interleukin-18 in diabetic nephropathy[J].International Journal of Endocrinology and Metabolism,2020,40(05):347-350.[doi:10.3760/cma.j.cn121383-20191210-12034]
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白细胞介素-18在糖尿病肾病中的介导作用()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
40
期数:
2020年05期
页码:
347-350
栏目:
综述
出版日期:
2020-09-20

文章信息/Info

Title:
Intermediate role of interleukin-18 in diabetic nephropathy
作者:
周茜1; 狄红杰1; 刘超2; 殷立平3
1南京中医药大学第二附属医院,江苏省第二中医院内分泌科 210017; 2南京中医药大学附属中西医结合医院内分泌科 210028; 3南京 中医药大学第二附属医院,江苏省第二中医院肾内科 210017
Author(s):
Zhou Qian1;  Di Hongjie1;  Liu Chao2;  Yin Liping3
1Department of Endocrinology, The Second Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Second Chinese Traditional Medicine Hospital, Nanjing 210017, China; 2Department of Endocrinology, Affiliated Hospital of Integrated Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210028, China; 3Department of Nephrology, The Second Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Second Chinese Medicine Hospital, Nanjing 210017, China
关键词:
糖尿病肾病;  IL-18;  炎症;  细胞凋亡;  氧化应激;  肿瘤坏死因子-α
Keywords:
Diabetic nephropathy;  IL-18;  Inflammation;  Apoptosis;  Oxidative stress;  Tumor necrosis factor-α
DOI:
10.3760/cma.j.cn121383-20191210-12034
文献标志码:
A
摘要:
糖尿病肾病(DN)是终末期肾脏疾病的主要原因,其发病机制尚未完全清楚。研究表明DN是一种炎症性疾病,在DN发病过程中白细胞介素-1(IL-1)、IL-6、IL-18、 肿瘤坏死因子-α(TNF-α)、转化生长因子-β(TGF-β)等参与了细胞黏附、分化与组织损伤。其中,IL-18更具有特异性,IL-18在肾组织中表达,并被包括高血糖在内的多种 刺激因子上调,IL-18表达的水平与糖尿病肾病的进展呈正相关。
Abstract:
Diabetic nephropathy(DN)is the main cause of end-stage renal disease, and its pathogenesis has not been fully understood. Studies show that DN is an inflammatory disease. During the pathogenesis of DN, interleukin-1(IL-1), IL-6,IL-18, tumor necrosis factor-α(TNF-α), transforming growth factor-β(TGF-β), etc. are involved in cell adhesion, differentiation and tissue damage. Among them, IL-18 is more specific. IL-18 is expressed in renal tissue and is upregulated by several stimuli including hyperglycemia. The expression of IL-18 is positively correlated with the progression of diabetic nephropathy.

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备注/Memo

备注/Memo:
通信作者:殷立平,Email:Yinliping003@aliyun.com
更新日期/Last Update: 2020-09-20