[1]白皙 朱惠娟 陈适 阳洪波 潘慧.生长激素对免疫系统功能的影响[J].国际内分泌代谢杂志,2020,40(01):45-48.[doi:10.3760/cma.j.issn.1673-4157.2020.01.010]
　Bai Xi,Zhu Huijuan,Chen Shi,et al.Influence of growth hormone on the function of immune system[J].International Journal of Endocrinology and Metabolism,2020,40(01):45-48.[doi:10.3760/cma.j.issn.1673-4157.2020.01.010]
点击复制

生长激素对免疫系统功能的影响()
分享到：

《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
40
期数:
2020年01期
页码:
45-48
栏目:
基础研究
出版日期:
2020-01-20

文章信息/Info

Title:
Influence of growth hormone on the function of immune system
作者:
白皙 朱惠娟 陈适 阳洪波 潘慧
中国医学科学院,北京协和医学院,北京协和医院内分泌科,国家卫生健康委员会内分泌重点实验室,协和转化医学中心 100730
Author(s):
Bai Xi;  Zhu Huijuan;  Chen Shi;  Yang Hongbo;  Pan Hui
Key Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, The Translational Medicine Center of Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College(CAMS & PUMC), Beijing 100730, China
关键词:
生长激素;  免疫系统;  固有免疫;  适应性免疫;  炎症
Keywords:
Growth hormone;  Immune system;  Innate immunity;  Adaptive immunity;  Inflammation
DOI:
10.3760/cma.j.issn.1673-4157.2020.01.010
摘要:
生长激素是一种由腺垂体前叶细胞分泌的肽类激素,可作用于多种免疫器官和免疫细胞,发挥免疫调节作用。在固有免疫系统中,生长激素可增强巨噬细胞、树突状细胞和自然杀伤细胞的免疫活性; 在适应性免疫系统中,生长激素可提高胸腺细胞的迁移能力,促进胸腺细胞亚群的调节,影响脾脏和B淋巴细胞的发育。此外,生长激素还可以影响机体的炎性反应状态,抑制胶原性关节炎的关节破坏,对艾滋病患者免疫系统也具有多种有益作用。因此,生长激素作为一种重要的免疫调节因子,有望在临床上成为抗感染、治疗免疫缺陷或免疫功能低下的一种有效手段。
Abstract:
Growth hormone(GH)is a peptide hormone secreted primarily by the somatotrophs in the anterior pituitary gland. It can act on varieties of immune organs or immune cells to exert immunomodulatory effect. In the innate immune system, GH can enhance the immunological activity of macrophages, dendritic cells and natural killer cells. In the adaptive immune system, GH can increase the migratory capacity of thymocytes, promote the modulation of thymocyte subsets and impact the development of the spleen and B lymphocytes. In addition, GH can influence the inflammatory state, prevent the inflammatory joint destruction in the collagen-induced arthritis. Moreover, low-dose GH therapy has beneficial effects on the immune system of patients with acquired immune deficiency syndrome. Therefore, GH, as an important immunoregulatory factor, is expected to become a potential therapy for the infectious diseases, immunodeficiency or immune dysfunction.

参考文献/References:

[1] Høybye C,Cohen P,Hoffman AR,et al.Status of long-acting-growth hormone preparations--2015[J].Growth Horm IGF Res,2015,25(5):201-206.DOI:10.1016/j.ghir.2015.07.004.
[2] Lesniak MA,Roth J.Regulation of receptor concentration by homologous hormone. Effect of human growth hormone on its receptor in IM-9 lymphocytes[J].J Biol Chem,1976,251(12):3720-3729.
[3] Hattori N. Expression, regulation and biological actions of growth hormone(GH)and ghrelin in the immunesystem[J].Growth Horm IGF Res,2009,19(3):187-197. DOI:10.1016/j.ghir.2008.12.001.
[4] Richmond E,Rogol AD.Current indications for growth hormone therapy for children and adolescents[J].Endocr Dev,2010,18:92-108.DOI:10.1159/000316130.
[5] Dos Santos Reis MD,Dos Santos YMO,de Menezes CA,et al.Resident murine macrophage migration and phagocytosis are modulated by growth hormone[J].Cell Biol Int,2018,42(5):615-623.DOI:10.1002/cbin.10939.
[6] Liu QL,Zhang J,Liu X,et al.Role of growth hormone in maturation and activation of dendritic cells via miR-200a and the Keap1/Nrf2 pathway[J].Cell Prolif,2015,48(5):573-581.DOI:10.1111/cpr.12206.
[7] Wei L,Chang J,Han Z,et al.Recombinant human growth hormone(rhGH)treatment of MKN-45 xenograft mice improves nutrition status and strengthens immune function without promoting tumor growth[J].PLoS One,2019,14(1):e0210613.DOI:10.1371/journal.pone.0210613.
[8] Bodart G,Farhat K,Charlet-Renard C,et al.The somatotrope growth hormone-releasing hormone/growth hormone/insulin-like growth factor-1 axis in immunoregulation and immunosenescence[J].Front Horm Res,2017,48:147-159.DOI:10.1159/000452913.
[9] Lins MP,de Araújo Vieira LF,Rosa AA,et al.Growth hormone in the presence of laminin modulates interaction of human thymic epithelial cells and thymocytes in vitro[J].Biol Res,2016,49(1):37.DOI:10.1186/s40659-016-0097-0.
[10] Bodart G,Farhat K,Renard-Charlet C,et al.The severe deficiency of the somatotrope GH-releasing hormone/growth hormone/insulin-like growth Factor 1 axis of Ghrh-/- mice is associated with an important splenic atrophy and relative B lymphopenia[J].Front Endocrinol(Lausanne),2018,9:296.DOI:10.3389/fendo.2018.00296.
[11] Oliveira CR,Salvatori R,Nóbrega LM,et al.Sizes of abdominal organs in adults with severe short stature due to severe, untreated, congenital GH deficiency caused by a homozygous mutation in the GHRH receptor gene[J].Clin Endocrinol(Oxf),2008,69(1):153-158.DOI:10.1111/j.1365-2265.2007.03148.x.
[12] Farhat K,Bodart G,Charlet-Renard C,et al.Growth hormone(GH)deficient mice with GHRH gene ablation are severely deficient in vaccine and immune responses against streptococcus pneumoniae[J].Front Immunol,2018,9:2175.DOI:10.3389/fimmu.2018.02175.
[13] Lohr J,Grotevendt A,Nauck M,et al.Relation of insulin-like growth factor-Ⅰ and IGF binding protein 3 with markers of inflammation: results of a population-based study[J].Clin Endocrinol(Oxf),2014,80(1):148-154.DOI:10.1111/cen.12241.
[14] Burgers AM,Biermasz NR,Schoones JW,et al.Meta-analysis and dose-response metaregression: circulating insulin-like growth factor Ⅰ(IGF-Ⅰ)and mortality[J].J Clin Endocrinol Metab,2011,96(9):2912-2920.DOI:10.1210/jc.2011-1377.
[15] Villares R,Criado G,Juarranz Y,et al.Inhibitory role of growth hormone in the induction and progression phases of collagen-induced arthritis[J].Front Immunol,2018,9:1165.DOI:10.3389/fimmu.2018.01165.
[16] Heijligenberg R,Sauerwein HP,Brabant G,et al.Circadian growth hormone secretion in asymptomatic human immune deficiency virus infection and acquired immunodeficiency syndrome[J].J Clin Endocrinol Metab,1996,81(11):4028-4032. DOI:10.1210/jcem.81.11.8923855.
[17] Hansen BR,Kolte L,Haugaard SB,et al.Improved thymic index, density and output in HIV-infected patients following low-dose growth hormone therapy: a placebo controlled study[J].AIDS,2009,23(16):2123-2131.DOI:10.1097/QAD.0b013e3283303307.
[18] Herasimtschuk AA,Hansen BR,Langkilde A,et al.Low-dose growth hormone for 40 weeks induces HIV-1-specific T cell responses in patients on effective combination anti-retroviral therapy[J].Clin Exp Immunol,2013,173(3):444-453. DOI: 10.1111/cei.12141.
[19] Lindboe JB,Langkilde A,Eugen-Olsen J,et al.Low-dose growth hormone therapy reduces inflammation in HIV-infected patients: a randomized placebo-controlled study[J].Infect Dis(Lond),2016,48(11-12):829-837.DOI:10.1080/23744235.2016.1201722.

相似文献/References:

[1]罗天谊,孙咏琪,魏莹.生长激素对1型糖尿病合并生长迟缓儿童影响的研究进展[J].国际内分泌代谢杂志,2023,43(03):203.[doi:10.3760/cma.j.cn121383-20220629-06066]
　Luo Tianyi,Sun Yongqi,Wei Ying..Effect of growth hormone in children with type 1 diabetes complicated with growth retardation[J].International Journal of Endocrinology and Metabolism,2023,43(01):203.[doi:10.3760/cma.j.cn121383-20220629-06066]

备注/Memo

备注/Memo:
通信作者:潘慧,Email:panhui20111111@163.com
基金项目:中国医学科学院医学与健康科技创新工程项目(2016-I2M-1-008)
Corresponding author: Pan Hui, Email:panhui20111111@163.com
Fund program:Chinese Academy of Medical Science Innovation Fund for Medical Science(2016-I2M-1-008)
更新日期/Last Update: 2020-01-20