[1]杨梦萦 袁莉.胰岛内源性胰高血糖素样肽-1信号的研究进展[J].国际内分泌代谢杂志,2019,39(06):413-418.[doi:10.3760/cma.j.issn.1673-4157.2019.06.013]
 Yang Mengying,Yuan Li.Recent progress of the islet endogenous glucagon-like peptide-1 signaling[J].International Journal of Endocrinology and Metabolism,2019,39(06):413-418.[doi:10.3760/cma.j.issn.1673-4157.2019.06.013]
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胰岛内源性胰高血糖素样肽-1信号的研究进展()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
39
期数:
2019年06期
页码:
413-418
栏目:
综述
出版日期:
2019-11-20

文章信息/Info

Title:
Recent progress of the islet endogenous glucagon-like peptide-1 signaling
作者:
杨梦萦 袁莉
华中科技大学同济医学院附属协和医院内分泌科,武汉 430022
Author(s):
Yang Mengying Yuan Li
Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
关键词:
胰岛 胰高血糖素样肽-1 胰岛功能 糖尿病
Keywords:
Islet Glucagon-like peptide 1 Islet function Diabetes mellitus
DOI:
10.3760/cma.j.issn.1673-4157.2019.06.013
摘要:
研究表明,在一些特定的条件如糖尿病、胰岛素抵抗、肥胖、妊娠等代谢应激过程中,胰岛α细胞可被诱导表达激素原转换酶1/3,进而产生有生物活性的胰高血糖素样肽-1(GLP-1)。这种在代谢应激条件下被激活的胰岛内源性GLP-1信号可能通过局部旁分泌形式作用于邻近的β细胞,作为保护胰岛β细胞免受代谢应激损伤的内源性适应性代偿性机制。而且,多种生理及病理因素如GLP-1、葡萄糖依赖性促胰岛素释放肽、胰岛素、胆囊收缩素及细胞因子如白细胞介素-6、基质细胞衍生因子-1等都可以通过多种细胞内信号机制调节胰岛内源性GLP-1信号的表达。以增强内源性GLP-1信号为靶点的药物可能用于糖尿病的治疗。
Abstract:
Recent studies have shown that islet α cells are induced to express prohormone convertases 1/3 and produce biologically active glucagon-like peptide(GLP)-1 under certain conditions such as diabetes, insulin resistance, obesity, pregnancy and other metabolic stress process. The endogenous GLP-1 signaling induced by metabolic stress may act on the adjacent β cells in a local paracrine manner, which acts as an endogenous adaptive compensatory mechanism to protect islet β cells from stress damage. Moreover, many factors such as GLP-1, gastric inhibitory polypeptide, insulin, cholecystokinin, and cytokines such as interleukin-6, stromal cell-derived factor-1, etc, can regulate the expression of endogenous GLP-1 in islets through a variety of intracellular signaling mechanisms. Drugs that target endogenous GLP-1 signaling in the islets may be a new and effective treatment for type 2 diabetes.

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备注/Memo

备注/Memo:
通信作者:袁莉,Email:yuanli18cn@163.com
Corresponding author: Yuan Li, Email: yuanli18cn@163.com
更新日期/Last Update: 2019-11-20