[1]丘如 黄贵心 黄晓君.双醋瑞因治疗2型糖尿病的研究进展[J].国际内分泌代谢杂志,2019,39(06):402-404.[doi:10.3760/cma.j.issn.1673-4157.2019.06.010]
　Qiu Ru,Huang Guixin,Huang Xiaojun.Research progress of diacerein in the treatment of type 2 diabetes mellitus[J].International Journal of Endocrinology and Metabolism,2019,39(06):402-404.[doi:10.3760/cma.j.issn.1673-4157.2019.06.010]
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双醋瑞因治疗2型糖尿病的研究进展()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
39
期数:
2019年06期
页码:
402-404
栏目:
综述
出版日期:
2019-11-20

文章信息/Info

Title:
Research progress of diacerein in the treatment of type 2 diabetes mellitus
作者:
丘如1 黄贵心2 黄晓君2
1广东医科大学研究生学院,湛江 524000; 2广东医科大学附属医院内分泌科,湛江 524000
Author(s):
Qiu Ru1;  Huang Guixin2;  Huang Xiaojun2
1Guangdong Medical University Graduate School, Zhanjiang 524000, China; 2Department of Endocrinology, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524000, China
关键词:
双醋瑞因;  炎症因子;  2型糖尿病;  胰岛素抵抗
Keywords:
Diacerein;  Inflammatory factor;  Type 2 diabetes mellitus;  Insulin resistance
DOI:
10.3760/cma.j.issn.1673-4157.2019.06.010
摘要:
双醋瑞因是白细胞介素(IL)-1受体阻滞剂之一,具有消炎、镇痛、退热等作用,可以促进软骨生成,是临床常用的一种骨关节消炎药物。目前发现,其能改善胰岛素信号转导、胰岛素抵抗及胰岛细胞损伤作用,增强胰岛素敏感性。因此,基于目前国内、外现有的研究文献,从作用机制、基础及临床研究、不良反应等方面介绍双醋瑞因治疗T2DM的研究进展,可为临床治疗提供科学的参考依据。
Abstract:
Diacerein is one of the interleukin(IL)-1 receptor blockers, which has the effects of anti-inflammation, antipain, antipyretic and so on. It can promote cartilage formation and is a commonly used anti-inflammatory drug for bone and joint. At present, it has been found that it can improve insulin signal transduction, insulin resistance and islet cell injury, and enhance insulin sensitivity. Therefore, based on the current research literature at home and abroad, from the aspects of mechanism, basic and clinical trial research, adverse reactions, etc., the introduction of research progress of diacerein in the treatment of type 2 diabetes could provide a scientific reference for clinical treatment.

参考文献/References:

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备注/Memo

备注/Memo:
通信作者:黄贵心,Email:hgx13702736397@163.com
Corresponding author:Huang Guixin, Email:hgx13702736397@163.com
更新日期/Last Update: 2019-11-20