[1]严克敏 朱惠娟 龚凤英.红花黄色素改善肝功能和糖脂代谢作用的研究进展[J].国际内分泌代谢杂志,2019,39(02):97-100.[doi:10.3760/cma.j.issn.1673-4157.2019.02.006]
　Yan Kemin,Zhu Huijuan,Gong Fengying.Advances in the roles of safflower yellow in improving liver function and glucose and lipid metabolism[J].International Journal of Endocrinology and Metabolism,2019,39(02):97-100.[doi:10.3760/cma.j.issn.1673-4157.2019.02.006]
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红花黄色素改善肝功能和糖脂代谢作用的研究进展()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
39
期数:
2019年02期
页码:
97-100
栏目:
综述
出版日期:
2019-03-20

文章信息/Info

Title:
Advances in the roles of safflower yellow in improving liver function and glucose and lipid metabolism
作者:
严克敏 朱惠娟 龚凤英
中国医学科学院,北京协和医学院,北京协和医院内分泌科,国家卫生健康委内分泌重点实验室,协和转化医学中心 100730
Author(s):
Yan Kemin;  Zhu Huijuan;  Gong Fengying
Department of Endocrinology, Key Laboratory of Endocrinology of National Health Commission, The Translational Medicine Center of Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China
关键词:
红花黄色素;  肝功能;  糖脂代谢;  脂肪;  肝脏
Keywords:
Safflower yellow;  Liver function;  Glucose and lipid metabolism;  Adipose tissue;  Liver
DOI:
10.3760/cma.j.issn.1673-4157.2019.02.006
摘要:
红花黄色素是中药红花的主要有效成分,已用于临床治疗心、脑血管疾病等。近年研究发现,红花黄色素还具有改善肝功能和糖、脂代谢的作用。一方面,红花黄色素能作用于肝脏,增强肝脏抗氧化应激的能力,减轻肝脏脂肪变性和纤维化; 另一方面,红花黄色素能作用于脂肪组织和脂肪细胞,激活胰岛素信号通路、促进白色脂肪组织棕色化、抑制脂质合成。红花黄色素具有上述改善代谢的作用,其有望成为未来治疗肥胖及其相关并发症的一种药物。
Abstract:
Safflower yellow, the main active component of the traditional Chinese medicine safflower, has been applied to clinical treatment for cardiovascular and cerebrovascular diseases. Recent studies have demonstrated that safflower yellow played a role in improving liver function and glucose and lipid metabolism. On one hand, safflower yellow could enhance the antioxidant capacity of liver and reduce steatosis and fibrosis of liver. On the other hand, safflower yellow could activate insulin signaling pathway, promote the browning of white adipose tissue and inhibit adipogenesis in adipose tissue and adipocytes. All of these beneficial effects of safflower yellow make it a potential drug to treat obesity and its related diseases in the future.

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备注/Memo

备注/Memo:
通信作者:龚凤英, Email:fygong@sina.com
基金项目:国家自然科学基金(30540036,30771026,81370898,81471024); 北京市自然科学基金(7082079,7182130); 人社部留学人员科技活动项目择优资助经费(启动类); 国家临床重点专科建设项目单位(WBYZ2011-873)
Corresponding author: Gong Fengying, Email: fygong@sina.com
Fund program:National Natural Science Foundation of China(30540036, 30771026, 81370898, 81471024); Natural Science Foundation of Beijing of China(7082079,7182130); Scientific Research Foundation for the Selected Returned Overseas Chinese Scholars, Ministry of Human Resources and Social Security of China; Program of National Key Clinical Specialty Construction(WBYZ2011-873)
更新日期/Last Update: 2019-03-20