[1]徐家欢 李文扬 王玮.下丘脑-垂体-靶腺轴在阻塞性睡眠呼吸暂停低通气综合征 患者认知障碍中的作用[J].国际内分泌代谢杂志,2018,38(05):350-353.[doi:10.3760/cma.j.issn.1673-4157.2018.05.017]
　Xu Jiahuan,Li Wenyang,Wang Wei.Effect of hypothalamus-pituitary-target gland axis on cognitive impairment in patients with obstructive sleep apnea-hypopnea syndrome[J].International Journal of Endocrinology and Metabolism,2018,38(05):350-353.[doi:10.3760/cma.j.issn.1673-4157.2018.05.017]
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下丘脑-垂体-靶腺轴在阻塞性睡眠呼吸暂停低通气综合征 患者认知障碍中的作用()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
38
期数:
2018年05期
页码:
350-353
栏目:
基础研究
出版日期:
2018-09-20

文章信息/Info

Title:
Effect of hypothalamus-pituitary-target gland axis on cognitive impairment in patients with obstructive sleep apnea-hypopnea syndrome
作者:
徐家欢 李文扬 王玮
作者单位:110001 沈阳,中国医科大学附属第一医院呼吸与危重症医学科
Author(s):
Xu Jiahuan;  Li Wenyang;  Wang Wei
Department of Respiratory and Critical Care Medicine, The First Hospital of China Medical University, Shenyang 110001, China
关键词:
阻塞性睡眠呼吸暂停低通气综合征;  下丘脑-垂体-靶腺轴;  认知障碍
Keywords:
Obstructive sleep apnea hypopnea syndrome;  Hypothalamus-pituitary-target gland axis;  Cognitive impairment
DOI:
10.3760/cma.j.issn.1673-4157.2018.05.017
摘要:
认知障碍是指大脑学习记忆、思维判断等过程出现异常的心理障碍性病态,严重影响患者的生活质量。近年来研究发现,阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者发生认知障碍的风险明显高于非OSAHS人群,但具体机制仍不清楚。有研究者发现,OSASH可引起下丘脑-垂体-靶腺轴激素水平变化,而后者又可通过一系列分子机制参与认知障碍的发生、发展。相应的激素替代治疗可改善患者的认知功能,对合并认知障碍的OSAHS患者的治疗具有指导意义。
Abstract:
Cognitive impairment refers to an abnormal psychological disorder of learning and memory, thinking and judgment, which seriously affects the quality of life of patients. In recent years, studies have found that the risk of cognitive impairment in patients with obstructive sleep apnea-hypopnea syndrome(OSAHS)was significantly higher than those without, but the exact mechanism remained unclear. Some researchers have found that OSASH could cause changes in the hormone levels of the hypothalamus-pituitary-target gland axis, which in turn could participate in the development of cognitive disorders through a series of molecular mechanisms. Hormone replacement therapy can improve the cognitive function of patients, which is a great significance to guide the treatment of cognitive impairment of patients with OSAHS.

参考文献/References:


[1] Kapur VK,Auckley DH,Chowdhuri S,et al.Clinical practice guideline for diagnostic testing for adult obstructive sleep apnea: an american academy of sleep medicine clinical practice guideline[J].J Clin Sleep Med,2017,13(3):479-504.DOI:10.5664/jcsm.6506.
[2] 冯学威,康健,王赞峰,等.阻塞性睡眠呼吸暂停低通气综合征患者下丘脑-垂体-肾上腺轴和生长激素轴激素水平的变化分析[J].中华结核和呼吸杂志,2006,29(4):230-232. DOI:10.3760/j:issn:1001-0939.2006.04.008.
[3] Li RC,Guo SZ,Raccurt M,et al.Exogenous growth hormone attenuates cognitive deficits induced by intermittent hypoxia in rats[J].Neuroscience,2011,196:237-250. DOI:10.1016/j.neuroscience.2011.08.029.
[4] Nair D,Ramesh V,Li RC,et al. Growth hormone releasing hormone(GHRH)signaling modulates intermittent hypoxia-induced oxidative stress and cognitive deficits in mouse[J].J Neurochem,2013,127(4):531-540. DOI:10.1111/jnc.12360.
[5] Chang WP,Liu ME,Chang WC,et al.Sleep apnea and the risk of dementia: a population-based 5-year follow-up study in Taiwan[J].PLoS One,2013,8(10):e78655.DOI:10.1371/journal.pone.0078655.
[6] 谢子珍, 龙才权, 孟晓梅, 等. 阻塞性睡眠呼吸暂停综合征成年患者认知障碍研究[J].实用医学杂志, 2016,32(6):955-957.DOI:10.3969/j.issn.1006-5725.2016.06.028.
[7] Zhou J,Camacho M,Tang X,et al.A review of neurocognitive function and obstructive sleep apnea with or without daytimesleepiness[J].Sleep Med,2016,23:99-108.DOI:10.1016/j.sleep.2016.02.008.
[8] Lam EWK,Chung F,Wong J.Sleep-disordered breathing, postoperative delirium, and cognitive impairment[J].Anesth Analg,2017,124(5):1626-1635.DOI:10.1213/ANE.0000000000001914.
[9] 王丽晶.腺样体肥大儿童生长激素和血清骨钙素的测定及其与身高体重的关系[D].吉林大学,2016.
[10] Izumi S,Ribeiro-Filho FF,Carneiro G,et al.IGF-1 levels are inversely associated with metabolic syndrome in obstructive sleep apnea[J].J Clin Sleep Med,2016,12(4):487-493.DOI:10.5664/jcsm.5672.
[11] Kritikou I,Basta M,Vgontzas AN,et al.Sleep apnoea and the hypothalamic-pituitary-adrenal axis in men and women: effects of continuous positive airway pressure[J].Eur Respir J,2016,47(2):531-540.DOI:10.1183/13993003.00319-2015.
[12] Baker LD,Barsness SM,Borson S,et al.Effects of growth hormone-releasing hormone on cognitive function in adults with mild cognitive impairment and healthy older adults: results of a controlled trial[J].Arch Neurol,2012,69(11):1420-1429.DOI:10.1001/archneurol.2012.1970.
[13] Zhang H,Han M,Zhang X,et al.The effect and mechanism of growth hormone replacement on cognitive function in rats with traumatic brain injury[J].PLoS One,2014,9(9):e108518.DOI:10.1371/journal.pone.0108518.
[14] Dykens EM,Roof E,Hunt-Hawkins H. Cognitive and adaptive advantages of growth hormone treatment in children with Prader-Willi syndrome[J].J Child Psychol Psychiatry,2017,58(1):64-74.DOI:10.1111/jcpp.12601.
[15] Elbornsson M,Horvath A,Götherström G,et al.Seven years of growth hormone(GH)replacement improves quality of life in hypopituitary patients with adult-onset GH deficiency[J].Eur J Endocrinol,2017,176(2):99-109.DOI:10.1530/EJE-16-0875.
[16] Kanbay A,Demir NC,Tutar N,et al.The effect of CPAP therapy on insulin-like growth factor and cognitive functions in obstructive sleep apnea patients[J].Clin Respir J,2017,11(4):506-513.DOI:10.1111/crj.12365.
[17] de la Tremblaye PB,Benoit SM,Schock S,et al.CRHR1 exacerbates the glial inflammatory response and alters BDNF/TrkB/pCREB signaling in a rat model of global cerebral ischemia: implications for neuroprotection and cognitive recovery[J].Prog Neuropsychopharmacol Biol Psychiatry,2017,79(Pt B):234-248.DOI:10.1016/j.pnpbp.2017.06.021.
[18] Le MH,Weissmiller AM,Monte L,et al.Functional impact of corticotropin-releasing factor exposure on tau phosphorylation and axon transport[J].PLoS One,2016,11(1):e0147250.DOI:10.1371/journal.pone.0147250.
[19] Grimm S,Gärtner M,Fuge P,et al.Variation in the corticotropin-releasing hormone receptor 1(CRHR1)gene modulates age effects on working memory[J].J Psychiatr Res,2015,61:57-63.DOI:10.1016/j.jpsychires.2014.12.001.
[20] Scantlebury MH,Chun KC,Ma SC,et al.Adrenocorticotropic hormone protects learning and memory function in epileptic Kcna1-null mice[J].Neurosci Lett,2017,645:14-18.DOI:10.1016/j.neulet.2017.02.069.
[21] Deuschle M,Gotthardt U,Schweiger U,et al.Hypothalamic-pituitary-adrenocortical dysfunction in elderly, male marathon runners: feedback sensitivity, stress response, and effects on verbal memory[J].Neuroendocrinology,2017,105(2):150-156.DOI:10.1159/000450856.
[22] Edwards KM,Kamat R,Tomfohr LM,et al.Obstructive sleep apnea and neurocognitive performance:the role of cortisol[J].Sleep Med,2014,15(1):27-32. DOI:10.1016/j.sleep.2013.08.789.
[23] Shavit Stein E,Itsekson Hayosh Z,Vlachos A,et al.Stress and corticosteroids modulate muscarinic long term potentiation(mLTP)in the hippocampus[J].Front Cell Neurosci,2017,11:299.DOI:10.3389/fncel.2017.00299.
[24] Dhikav V,Anand KS.Glucocorticoids may initiate Alzheimer's disease: a potential therapeutic role for mifepristone(RU-486)[J].Med Hypotheses,2007,68(5):1088-1092.DOI:10.1016/j.mehy.2006.09.038.

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备注/Memo

备注/Memo:
基金项目:辽宁省科学技术计划项目(2017225022)
Fund program:Science and Technology Project of Liaoning Province(2017225022)
作者单位:110001 沈阳,中国医科大学附属第一医院呼吸与危重症医学科
通信作者:王玮,Email:wwbycmu@126.com
更新日期/Last Update: 2018-09-30