[1]王静 张梅.胰高血糖素在1型糖尿病治疗中的研究进展[J].国际内分泌代谢杂志,2018,38(01):19-22.[doi:10.3760/cma.j.issn.1673-4157.2018.01.005]
 Wang Jing,Zhang Mei.Research progress of glucagon for the treatment of type 1 diabetes mellitus[J].International Journal of Endocrinology and Metabolism,2018,38(01):19-22.[doi:10.3760/cma.j.issn.1673-4157.2018.01.005]
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胰高血糖素在1型糖尿病治疗中的研究进展()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
38
期数:
2018年01期
页码:
19-22
栏目:
综述
出版日期:
2018-01-20

文章信息/Info

Title:
Research progress of glucagon for the treatment of type 1 diabetes mellitus
作者:
王静 张梅
210029 南京医科大学第一附属医院内分泌科
Author(s):
Wang Jing Zhang Mei
Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
关键词:
1型糖尿病 胰高血糖素 胰高血糖素样肽-1
Keywords:
Type 1 diabetes mellitus Glucagon Glucagon like peptide-1
DOI:
10.3760/cma.j.issn.1673-4157.2018.01.005
摘要:
葡萄糖在体内的平衡依赖于胰岛α细胞分泌的胰高血糖素以及β细胞分泌的胰岛素的精确调节。胰高血糖素在1型糖尿病患者中分泌异常,提示其在1型糖尿病的发生、发展中起重要的辅助作用。作为升糖激素,胰高血糖素用于治疗1型糖尿病患者的低血糖。此外,阻断胰高血糖素受体或抑制α细胞分泌胰高血糖素并以胰高血糖素为靶点研制临床药物已成为1型糖尿病治疗的热点。胰岛素联合胰高血糖素的“双激素治疗”成为治疗1型糖尿病的新方向。
Abstract:
The balance of glucose in the body depends on the precise regulation of glucagon secreted by pancreatic islet α cells and insulin secreted by β cells. The secretion of glucagon is abnormal in type 1 diabetes, suggesting that it plays an important auxiliary role in the occurrence and development of type 1 diabetes. As a hormone that raises blood glucose, glucagon is used to treat hypoglycemia in patients with type 1 diabetes. In addition,blocking the glucagon receptor or inhibiting the secretion of glucagon by α cells and taking glucagon as a target to develop clinical drugs have become the focus of the treatment of type 1 diabetes. Insulin combined with glucagon, the "double hormone therapy",now has become a new direction for the treatment of type 1 diabetes.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金(81070622,81370939,81670756); 江苏省“333高层次人才培养工程”(2016-7)
通信作者:张梅,Email:zhangmei@njmu.edu.cn
更新日期/Last Update: 2018-01-30