[1]张薛,刘海霞,吕啸舒,等.甲状腺自身免疫致不孕流产的机制[J].国际内分泌代谢杂志,2017,37(05):348-351.
　Zhang Xue,Liu Haixia,Lyu Xiaoshu,et al.Mechanisms of infertility and miscarriage caused by thyroid autoimmunity[J].International Journal of Endocrinology and Metabolism,2017,37(05):348-351.
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甲状腺自身免疫致不孕流产的机制()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
37
期数:
2017年05期
页码:
348-351
栏目:
综述
出版日期:
2017-09-20

文章信息/Info

Title:
Mechanisms of infertility and miscarriage caused by thyroid autoimmunity
作者:
张薛; 刘海霞; 吕啸舒; 王刚
116021 大连医科大学附属第二医院内分泌代谢病科
Author(s):
Zhang Xue;  Liu Haixia;  Lyu Xiaoshu;  Wang Gang.
Department of Endocrinology and Metabolism, The Second Affiliated Hospital, Dalian Medical University, Dalian 116021, China
关键词:
甲状腺自身免疫;  不孕;  流产;  治疗
Keywords:
Thyroid autoimmunity;  Infertility;  Miscarriage;  Treatment
文献标志码:
A
摘要:
母体甲状腺自身免疫与不孕、流产、早产及新生儿智力发育障碍密切相关,是导致育龄期妇女甲状腺功能障碍的主要原因。甲状腺自身免疫导致女性不孕与流产的机制,包括T细胞异常、自然杀伤细胞高度活化、多克隆B细胞激活、维生素D缺乏以及甲状腺自身抗体与甲状腺外位点交叉反应学说等。存在甲状腺自身免疫的妇女,不论是否存在甲状腺功能障碍,给予左甲状腺素或硒制剂治疗都可能会改善妊娠结局。因此,筛查和治疗甲状腺自身免疫的育龄女性会优化生殖、生育。
Abstract:
There exsits a significant association between maternal thyroid autoimmunity, infertility, miscarriage and poor neurodevelopment in the offspring. Thyroid autoimmunity is the leading cause of thyroid dysfunction in women of reproductive age. The pathogenesis that underlies infertility and miscarriage caused by thyroid autoimmunity includes T cell abnormality, hyperactivity of natural killer cells, polyclonal B cell activation, vitamin D deficiency, cross reactivity of thyroid auto-antibodies with extrathyroid sites and so on. Thyroxine supplementation or selenium treatment may influence the pregnant outcomes of auto-antibodies positive women whenever accompanied with thyroid dysfunction. Thus, it is necessary to identify and treat the women with thyroid autoimmunity in order to improve the reproductive outcomes.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助项目(81600605); 辽宁省省直医院临床能力建设项目(LNCCC-D23-2015); 辽宁省教育厅科学研究一般项目(L2015146)
通信作者:刘海霞,Email:dllhx1017@163.com
更新日期/Last Update: 2017-09-30