[1]程海燕,吴文君,卜瑞芳.垂体柄阻断综合征的病因分析及诊疗进展[J].国际内分泌代谢杂志,2016,36(06):397-399.[doi:10.3760/cma.j.issn.1673-4157.2016.06.10]
 Cheng Haiyan,Wu Wenjun,Bu Ruifang..Etiology analysis and treatment of pituitary stalk interruption syndrome[J].International Journal of Endocrinology and Metabolism,2016,36(06):397-399.[doi:10.3760/cma.j.issn.1673-4157.2016.06.10]
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垂体柄阻断综合征的病因分析及诊疗进展()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
36
期数:
2016年06期
页码:
397-399
栏目:
综述
出版日期:
2016-11-20

文章信息/Info

Title:
Etiology analysis and treatment of pituitary stalk interruption syndrome
作者:
程海燕吴文君卜瑞芳
214000 无锡,南京医科大学附属无锡市人民医院内分泌科
Author(s):
Cheng HaiyanWu Wenjun Bu Ruifang.
Department of Endocrinology, Nanjing Medical University Affiliated Wuxi People Hospital, Wuxi 214000, China
关键词:
垂体柄阻断综合征 HESX1基因 LHX4基因
Keywords:
Pituitary stalk interruption syndrome HESX1 gene LHX4 gene
DOI:
10.3760/cma.j.issn.1673-4157.2016.06.10
摘要:
垂体柄阻断综合征(PSIS)的病因和发病机制目前尚不明确。近来研究表明,有遗传因素参与PSIS的发生、发展,尤以HESX1、LHX4基因缺陷最为密切。PSIS的临床表现复杂多样,随不同年龄及不同垂体激素缺乏而表现各异。早期诊治对患者激素缺乏症状的改善至关重要,MRI是唯一能明确此病诊断的影像学方法,胰岛素样生长因子及其结合蛋白3可与MRI联合提高对PSIS的诊断率。
Abstract:
The etiology and pathogenesis of pituiatary stalk interrccption syndrome(PSIS)is still unclear. Recent studies suggest that genetic factors take a great part in the etiopathogenisis of PSIS, especially the defect of gene HESX1 and LHX4. The clinical manifestations of PSIS are complex and diverse, because they change with different ages and different types of hormone deficiencies. Early diagnosis and treatment is very important to improve the clinical manifestation of these patients. MRI is the only imageological examination to diagnose PSIS, and insulin-like growth factor-1 and its binding protein 3 combined with MRI can improve the diagnostic rate of PSIS.

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更新日期/Last Update: 2016-12-20