[1]周胜元,刘玥,侯长青,等.糖尿病肾病患者血清电解质水平变化的 研究[J].国际内分泌代谢杂志,2016,36(01):6-9.[doi:10.3760/cma.j.issn.1673-4157.2016.01.002]
　Zhou Shengyuan*,Liu Yue,Hou Changqing,et al.Changes of serum electrolytes in patients with diabetic nephropathy[J].International Journal of Endocrinology and Metabolism,2016,36(01):6-9.[doi:10.3760/cma.j.issn.1673-4157.2016.01.002]
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糖尿病肾病患者血清电解质水平变化的 研究()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
36
期数:
2016年01期
页码:
6-9
栏目:
论著
出版日期:
2016-01-20

文章信息/Info

Title:
Changes of serum electrolytes in patients with diabetic nephropathy
作者:
周胜元; 刘玥; 侯长青; 高常柏; 富利燕; 孟祥震
300150 天津中医药大学第二附属医院肾病科(周胜元,侯长青,高常柏,富利燕,孟祥震); 300191 天津人民医院心内科(刘玥)
Author(s):
Zhou Shengyuan*; Liu Yue; Hou Changqing; Gao Changbai; Fu Liyan; Meng Xiangzhen.
*Department of Nephropathy, The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300150, China
关键词:
糖尿病肾病;  电解质;  尿白蛋白
Keywords:
Diabetic nephropathy;  Electrolyte;  Urinary albumin
DOI:
10.3760/cma.j.issn.1673-4157.2016.01.002
摘要:
目的 探讨糖尿病肾病(DN)患者血清电解质变化,及与尿微量白蛋白的相关性。方法 选取2013年4月至2014年10月在天津中医药大学第二附属医院内科住院的2型糖尿病患者450例,按尿微量白蛋白排泄率(UAER)结果分为3组,<20 μg/min为无DN组(176例),20～200 μg/min为微量白蛋白尿组(182例),≥200 μg/min为大量白蛋白尿组(92例)。同时检测患者血清电解质钾、钠、氯、磷、镁、钙水平,并留取患者一般资料,分析各种电解质变化与DN的关系。结果 3组间的钾、磷、钙、镁水平有差异,大量白蛋白尿组的钾(F=11.139,P<0.01)、磷(F=3.115,P<0.05)水平最高,镁(F= 7.251,P<0.05)、钙(F=5.721,P<0.01)水平最低。微量白蛋白尿组与大量白蛋白尿组患者的钾、磷水平均高于无DN组,镁水平低于无DN组(P<0.05或P<0.01)。大量白蛋白尿组钙水平低于无DN组(P<0.01)。与微量白蛋白尿组相比,大量白蛋白尿组钾、磷水平升高,而钙、镁水平降低(P<0.05或P<0.01)。直线相关分析显示,磷、钾水平与24 h尿微量白蛋白呈正相关(r=0.348,0.258,P<0.001)。钙、镁水平与24 h尿微量白蛋白呈负相关(r=-0.360,-0.374,P<0.001)。结论 DN患者随着尿微量白蛋白的增多,钾、磷水平逐渐升高,镁、钙水平逐渐降低。
Abstract:
Objective To explore the changes of serum electrolytes in patients with diabetic nephropathy(DN),and the correlation between electrolytes and urinary microalbumin.Methods A total of 450 patients with type 2 diabetes were included from April 2013 to October 2014 in the Department of Internal Medicine of the Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine. According to urinary albumin excretion rate(UAER),all patients were divided into three groups: normal albuminuria group(UAER<20 μg/min,n=176), microalbuminuria group(20 μg/min ≤UAER<200 μg/min,n=182),macroalbuminuria group(UAER ≥200 μg/min,n=92).The levels of serum electrolytes including potassium(K), sodium(Na), chlorine(Cl), phosphorus(P), magnesium(Mg), and calcium(Ca)were detected. The clinical characteristics were recorded. The relationship between various electrolytes and DN was analyzed. Results K,P,Ca,and Mg were significantly different among the three groups.In macroalbuminuria group,the levels of K(F=11.139,P<0.01)and P(F=3.115,P<0.05)were higher,while the levels of Mg(F= 7.251,P<0.05)and Ca(F=5.721,P<0.01)were lower than those of other groups.The levels of K and P in microalbuminuria group and macroalbuminuria group were significantly higher than those of normal albuminuria group, and Mg was lower than that of normal albuminuria group(P<0.05 or P<0.01). The level of Ca in macroalbuminuria group was lower than that of normal albuminuria group(P<0.01).Compared with microalbuminuria group,the levels of K and P in macroalbuminuria group were higher,while the levels of Ca and Mg were lower(P<0.05 or P<0.01).Linear correlation analysis showed that there was a positive correlation between P,K and 24 h urine microalbumin(r=0.348,0.258,P<0.001),and a negative correlation between Ca,Mg and 24 h urine microalbumin(r=-0.360,-0.374,P<0.001).Conclusion With the increase of urinary albumin excretion, the levels of K and P gradually increase,while the levels of Ca and Mg gradually decrease.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助项目(81200158)
更新日期/Last Update: 2016-01-20