[1]冯玲,颜晓东.脂肪细胞因子与糖尿病心肌病变[J].国际内分泌代谢杂志,2015,(03):202-204.[doi:10.3760/cma.j.issn.1673-4157.2015.03.017]
 Feng Ling,Yan Xiaodong..Adipokines and diabetic cardiomyopathy[J].International Journal of Endocrinology and Metabolism,2015,(03):202-204.[doi:10.3760/cma.j.issn.1673-4157.2015.03.017]
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脂肪细胞因子与糖尿病心肌病变()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
期数:
2015年03
页码:
202-204
栏目:
综述
出版日期:
2015-05-20

文章信息/Info

Title:
Adipokines and diabetic cardiomyopathy
作者:
冯玲颜晓东
530021 南宁,广西壮族自治区人民医院内分泌科
Author(s):
Feng LingYan Xiaodong.
Department of Endocrinology,Guangxi Zhuang Autonomous Region People's Hospital,Nanning 530021,China Corresponding author:Yan Xiaodong,Email:xiaodong930111@163.com
关键词:
糖尿病心肌病变脂肪细胞因子心肌纤维化
Keywords:
Diabetic cardiomyopathyAdipokinesMyocardial fibrosis
DOI:
10.3760/cma.j.issn.1673-4157.2015.03.017
摘要:
糖尿病心肌病变在病理上主要表现为心肌间质重构和心肌纤维化,其具体发病机制尚不明确,与糖代谢障碍、心肌微血管病变等有关。新近研究发现脂肪组织可分泌多种生物活性物质如apelin、网膜素、visfatin、chemerin等,这些脂肪因子可能通过影响肾素-血管紧张素系统、心肌胰岛素抵抗、心肌能量代谢及心肌血管内皮功能等途径直接或间接影响心肌纤维化过程,进而对糖尿病心肌病变产生作用。
Abstract:
The remodeling and fibrosis of myocardial interstitial are main pathological manifestations of diabetic cardiomyopathy. The mechanism of diabetic cardiomyopathy is not clear,but may be related to disorder of glycometabolism,myocardial microvascular lesions and so on. Adipose tissue can secret many bioactive factors,such as apelin,omentin,visfatin,chemerin and so on. The effects of these adipokines on renin-angiotensin system,myocardial insulin resistance,cardiac energy metabolism and vascular endothelial function may directly or indirectly affect myocardial fibrosis,which then play roles in diabetic cardiomyopathy.

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备注/Memo

备注/Memo:
通信作者:颜晓东,Email:xiaodong930111@163.com
更新日期/Last Update: 2015-05-20