[1]任星星,郑爽,胡耀敏.脂蛋白脂酶基因突变与内分泌代谢疾病的关系[J].国际内分泌代谢杂志,2015,(02):100-102,113.[doi:10.3760/cma.j.issn.1673-4157.2015.02.007]
 Ren Xingxing,Zheng Shuang,Hu Yaomin..Relationship between lipoprotein lipase gene mutation and metabolic diseases[J].International Journal of Endocrinology and Metabolism,2015,(02):100-102,113.[doi:10.3760/cma.j.issn.1673-4157.2015.02.007]
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脂蛋白脂酶基因突变与内分泌代谢疾病的关系()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
期数:
2015年02
页码:
100-102,113
栏目:
综述
出版日期:
2015-03-20

文章信息/Info

Title:
Relationship between lipoprotein lipase gene mutation and metabolic diseases
作者:
任星星郑爽胡耀敏
200127 上海交通大学医学院附属仁济医院内分泌科
Author(s):
Ren XingxingZheng ShuangHu Yaomin.
Department of Endocrinology,Renji Hospital,School of Medicine,Shanghai Jiaotong University,Shanghai 200127,China Corresponding author:Hu Yaomin,Email:amin99@163.com
关键词:
脂蛋白脂酶基因突变高甘油三酯血症糖尿病
Keywords:
Lipoprotein lipaseGene mutationHypertriglyceridemiaDiabetes mellitus
DOI:
10.3760/cma.j.issn.1673-4157.2015.02.007
摘要:
脂蛋白脂酶是甘油三酯代谢的关键酶。脂蛋白脂酶基因突变将导致其结构和功能变异,通过影响其活性和含量而影响其脂解功能,进而影响全身脂质代谢和分布。研究发现,脂蛋白脂酶基因突变与高甘油三酯血症、肥胖、糖尿病等内分泌代谢疾病的发生、发展密切相关。脂蛋白脂酶基因可能成为上述疾病早期干预和治疗的新方向。
Abstract:
Lipoprotein lipase is a key enzyme of triglycerides metabolism. Mutations will cause variations in the structure and function of lipoprotein lipase gene,affecting the lipolytic function by altering its activity and level,which further affects the whole body lipid metabolism and distribution. Recent studies have found that these mutations are associated with hypertriglyceridemia,obesity,diabetes mellitus and so on. Lipoprotein lipase may become a novel target for the early prevention and treatment of these diseases.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助项目(81270946, 81170758, 30670988)      通信作者:胡耀敏,Email: amin99@163.com
更新日期/Last Update: 2015-03-20