[1]刘春梅,周涛,吴鹏,等.脉管复康片对糖尿病下肢动脉闭塞症患者内皮细胞功能影响的临床研究[J].国际内分泌代谢杂志,2014,(06):418-421.[doi:10.3760/cma.j.issn.1673-4157.2014.06.016]
　Liu Chunmei*,Zhou Tao,Wu Peng,et al.Effects of Maiguan Fukang tablets on endothelial cell function in patients with diabetic arterial occlusion of lower extremities[J].International Journal of Endocrinology and Metabolism,2014,(06):418-421.[doi:10.3760/cma.j.issn.1673-4157.2014.06.016]
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脉管复康片对糖尿病下肢动脉闭塞症患者内皮细胞功能影响的临床研究()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
期数:
2014年06期
页码:
418-421
栏目:
短篇论著
出版日期:
2014-12-20

文章信息/Info

Title:
Effects of Maiguan Fukang tablets on endothelial cell function in patients with diabetic arterial occlusion of lower extremities
作者:
刘春梅; 周涛; 吴鹏; 孙强; 郭亚南
250014 济南, 山东中医药大学附属医院周围血管病科(刘春梅); 250033 济南,山东大学第二医院周围血管病科(周涛,吴鹏,孙强,郭亚南)
Author(s):
Liu Chunmei*;  Zhou Tao;  Wu Peng;  Sun Qiang;  Guo Yanan.
*Department of Peripheral Vascular Diseases, Affliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan 250014,China
关键词:
脉管复康片;  内皮细胞功能;  糖尿病下肢动脉闭塞症
Keywords:
Maiguan Fukang tablets;  Endothelial cell function;  Diabetic arterial occlusion of lower extremities
DOI:
10.3760/cma.j.issn.1673-4157.2014.06.016
摘要:
目的 观察糖尿病下肢动脉闭塞症(DAO)患者血管内皮细胞功能的变化及脉管复康片干预的作用机制。方法 66例DAO患者按随机表法分为治疗组与对照组,每组33例,分别服用脉管复康片4片/次,3次/d; 或通塞脉片4片/次,3次/d,疗程均为8周。观察两组患者治疗后临床症状、体征、光电血流描记、踝/肱比指数以及血液流变学、内皮细胞因子等指标。结果 治疗组在改善临床症状方面优于对照组(P<0.05); 治疗后两组血黏度、纤维蛋白原均有降低,治疗组比对照组更为显著(P<0.01); 治疗后在血浆一氧化氮、内皮素-1水平变化方面,治疗组效果优于对照组,有显著性差异(P<0.01)。结论 脉管复康片可改善DAO患者临床症状,主要是通过调节血管内皮细胞功能,降低血黏度发挥作用。
Abstract:
Objective To investigate the effects and mechanisms of Maiguan Fukang tablets on the function of vascular endothelial cells in patients with diabetic arterial occlusion of lower extremities(DAO). Methods Sixty-six patients with DAO were divided into treatment group and control group by random table method, with 33 patients in each group. Four pieces of Maiguan Fukang tablets or Tongsaimai tablets three times a day were prescribed to the patients for 8 weeks. The clinical symptoms and signs, photoelectric flow tracings, ankle brachial index, heamorheology, markers of endothelial cell function were assessed after treatment. Results Clinical symptoms were improved in treatment group compared with control group(P<0.05). Blood viscosity and fibrinogen level were reduced in both groups, but were more evident in treatment group(P<0.01). Plasma nitric oxide and endothelin-1 level in treatment group were also improved significantly compared with those in control group(P<0.01). Conclusion Maiguan Fukang tablets can improve the clinical symptoms for patients with DAO, which may act through regulating vascular endothelial function and decreasing blood viscosity.

参考文献/References:

[1] 崔公让.糖尿病肢体动脉闭塞症诊断及疗效标准(草案)[J].中西医结合心脑血管病杂志,2004,2(6):352.
[2] 郑筱萸.中药新药临床研究指导原则[M].北京:中国医药科技出版社,2002,84.
[3] Faglia E. Characteristics of peripheral arterial disease and its relevance to the diabetic population.Int J Low Extrem Wounds, 2011,10(3):152-166.
[4] 于方举,侯玉芬.糖尿病肢体动脉闭塞症中医药治疗进展[J].中国中西医结合外科杂志,2009,15(5):566-567.
[5] 于海燕,陈大江. 脉管复康片中丹参酮的含量测定[J].黑龙江医药,2004,17(4):245-246.
[6] 朱明娟,何一心,王红星,等.通脉灵对小鼠组织缺血缺氧的保护作用[J].天津中医,1986,3(2):35-38.
[7] Mafrici A, Proietti R.Atherothrombosis in patients with type 2 diabetes mellitus: an overview of pathophysiology.G Ital Cardiol(Rome),2010,11(6):467-477.
[8] Ruiter MS, van Golde JM, Schaper NC, et al. Diabetes impairs arteriogenesis in the peripheral circulation: review of molecular mechanisms.Clin Sci(Lond), 2010,119(6):225-238.
[9] Weiss N.A critical review on the use of lipid apheresis and rheopheresis for treatment of peripheral arterial disease and the diabetic foot syndrome[J].Semin Dial, 2012, 25(2):220-227.
[10] 陈柏楠,秦红松,刘政.糖尿病肢体动脉闭塞症血管张力因素的变化特点[J].中国中西医结合杂志,2004,24(9):798-800.

更新日期/Last Update: 2014-12-20