[1]吕福平,黄才博,薛耀明.脂质异位沉积与慢性肾脏疾病[J].国际内分泌代谢杂志,2014,(06):390.[doi:10.3760/cma.j.issn.1673-4157.2014.06.008]
 Lv Fuping,Huang Caibo,Xue Yaoming..Ectopic lipid accumulation and chronic kidney disease[J].International Journal of Endocrinology and Metabolism,2014,(06):390.[doi:10.3760/cma.j.issn.1673-4157.2014.06.008]
点击复制

脂质异位沉积与慢性肾脏疾病()
分享到:

《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
期数:
2014年06期
页码:
390
栏目:
综述
出版日期:
2014-12-20

文章信息/Info

Title:
Ectopic lipid accumulation and chronic kidney disease
作者:
吕福平黄才博薛耀明
510515 广州,南方医科大学南方医院内分泌代谢科
Author(s):
Lv FupingHuang CaiboXue Yaoming.
Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou 510515,China
关键词:
脂质异位沉积 慢性肾脏疾病 脂代谢 脂毒性
Keywords:
Ectopic lipid accumulation Chronic kidney disease Lipid metabolism Lipotoxicity
DOI:
10.3760/cma.j.issn.1673-4157.2014.06.008
摘要:
慢性肾脏疾病(CKD)患者常伴有脂代谢紊乱,其中脂质异位沉积被证明与CKD患者疾病进展密切相关。近年研究发现,CKD中异位脂质的形成可能由尿毒症毒素累积等因素引起,并且固有脂肪组织的异常是CKD脂质重分布的核心环节。沉积的脂质通过加重肾脏功能损害,介导胰岛素抵抗,促进心血管事件的发生,从而严重影响CKD患者预后。相关研究为理解CKD状态下的脂代谢紊乱拓宽了视野,有助于发现脂质异位沉积的治疗靶点。
Abstract:
Altered lipid metabolism, especially ectopic lipid accumulation, is an important contributors to the progression of chronic kidney disease(CKD).Recent studies suggest that increasing uremic toxin may lead to ectopic lipid accumulation, and the disturbance of inherent adipose tissue is the central part of lipid redistribution in CKD. Ectopic lipid accumulation severely affects the prognosis of patients with CKD by accelerating kidney injury, inducing insulin resistance and increasing cardiovascular events. Related studies are helpful to improve our understanding of abnormal lipid metabolism of CKD as well as to find out the therapeutic target of ectopic lipid accumulation.

参考文献/References:

[1] Zhao HL,Sui Y,Guan J, et al.Fat redistribution and adipocyte transformation in uninephrectomized rats[J].Kidney Int,2008,74(4):467-477.
[2] Koppe L,Pillon NJ,Vella RE, et al.p-Cresyl sulfate promotes insulin resistance associated with CKD[J].J Am Soc Nephrol,2013,24(1):88-99.
[3] Vaziri ND,Yuan J,Ni Z, et al.Lipoprotein lipase deficiency in chronic kidney disease is accompanied by down-regulation of endothelial GPIHBP1 expression[J].Clin Exp Nephrol,2012,16(2):238-243.
[4] Jin K,Norris K,Vaziri ND.Dysregulation of hepatic fatty acid metabolism in chronic kidney disease[J].Nephrol Dial Transplant,2013,28(2):313-320.
[5] Axelsson J,Astr?m G,Sj?lin E, et al.Uraemic sera stimulate lipolysis in human adipocytes: role of perilipin[J].Nephrol Dial Transplant,2011,26(8):2485-2491.
[6] Pelletier CC,Koppe L,Croze ML, et al.White adipose tissue overproduces the lipid-mobilizing factor Zinc α2-glycoprotein in chronic kidney disease[J].Kidney Int,2013,83(5):878-886.
[7] Roubicek T,Bartlova M,Krajickova J, et al.Increased production of proinflammatory cytokines in adipose tissue of patients with end-stage renal disease[J].Nutrition,2009,25(7/8):762-768.
[8] Zhao HL,Sui Y,He L, et al.Lipid partitioning after uninephrectomy[J].Acta Diabetol,2011,48(4):317-328.
[9] Kalbacher E,Koppe L,Zarrouki B, et al.Human uremic plasma and not urea induces exuberant secretion of leptin in 3T3-L1 adipocytes[J].J Ren Nutr,2011,21(1):72-75.
[10] Li J,Guan M,Li C, et al.The dipeptidyl peptidase-4 inhibitor sitagliptin protects against dyslipidemia-related kidney injury in apolipoprotein E knockout mice[J].Int J Mol Sci,2014,15(7):11416-11434.
[11] Declèves AE,Zolkipli Z,Satriano J, et al.Regulation of lipid accumulation by AMP-activated kinase [corrected] in high fat diet-induced kidney injury[J].Kidney Int,2014,85(3):611-623.
[12] Chavez JA,Summers SA.A ceramide-centric view of insulin resistance[J].Cell Metab,2012,15(5):585-594.
[13] Li Z,Woollard JR,Wang S, et al.Increased glomerular filtration rate in early metabolic syndrome is associated with renal adiposity and microvascular proliferation[J].Am J Physiol Renal Physiol,2011,301(5):F1078-F1087.
[14] Tanaka Y,Kume S,Araki SI, et al.Fenofibrate, a PPARα agonist, has renoprotective effects in mice by enhancing renal lipolysis[J].Kidney Int,2011,79(8):871-882.
[15] Jauregui A,Mintz DH,Mundel P, et al.Role of altered insulin signaling pathways in the pathogenesis of podocyte malfunction and microalbuminuria[J].Curr Opin Nephrol Hypertens,2009,18(6):539-545.
[16] Welsh GI,Hale LJ,Eremina V, et al.Insulin signaling to the glomerular podocyte is critical for normal kidney function[J].Cell Metab,2010,12(4):329-340.
[17] Lennon R,Pons D,Sabin MA, et al.Saturated fatty acids induce insulin resistance in human podocytes: implications for diabetic nephropathy[J].Nephrol Dial Transplant,2009,24(11):3288-3296.
[18] Holland WL,Miller RA,Wang ZV, et al.Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin[J].Nat Med,2011,17(1):55-63.
[19] Siew ED,Ikizler TA.Insulin resistance and protein energy metabolism in patients with advanced chronic kidney disease[J].Semin Dial,2010,23(4):378-382.
[20] Samuel VT,Liu ZX,Wang A, et al.Inhibition of protein kinase Cepsilon prevents hepatic insulin resistance in nonalcoholic fatty liver disease[J].J Clin Invest,2007,117(3):739-745.
[21] Sun X,Pan H,Tan H, et al.High free fatty acids level related with cardiac dysfunction in obese rats[J].Diabetes Res Clin Pract,2012,95(2):251-259.
[22] Ouwens DM,Sell H,Greulich S, et al.The role of epicardial and perivascular adipose tissue in the pathophysiology of cardiovascular disease[J].J Cell Mol Med,2010,14(9):2223-2234.
[23] Kerr JD,Holden RM,Morton AR, et al.Associations of epicardial fat with coronary calcification, insulin resistance, inflammation, and fibroblast growth factor-23 in stage 3-5 chronic kidney disease[J].BMC Nephrol,2013,14:26.

相似文献/References:

[1]张睿,刘帅辉,于珮.痛风合并慢性肾脏疾病的药物治疗[J].国际内分泌代谢杂志,2016,36(02):82.[doi:10.3760/cma.j.issn.1673-4157.2016.02.003]
 Zhang Rui,Liu Shuaihui,Yu Pei..Drug therapy of gout combined with chronic kidney disease[J].International Journal of Endocrinology and Metabolism,2016,36(06):82.[doi:10.3760/cma.j.issn.1673-4157.2016.02.003]
[2]杜娟,夏维波.成纤维细胞生长因子-23的代谢调控及与疾病的关系[J].国际内分泌代谢杂志,2017,37(02):123.[doi:10.3760/cma.j.issn.1673-4157.2017.02.014]
 Du Juan,Xia Weibo..The metabolic regulation of fibroblast growth factor-23 and its relation with diseases[J].International Journal of Endocrinology and Metabolism,2017,37(06):123.[doi:10.3760/cma.j.issn.1673-4157.2017.02.014]
[3]《恩格列净/二甲双胍复方制剂临床应用专家指导意见》编写组.恩格列净/二甲双胍复方制剂临床应用专家指导意见[J].国际内分泌代谢杂志,2022,42(05):451.[doi:10.3760/cma.j.cn121383-20220530-05068]
 Expert Group for Guidance of EMPA/MET FDC.Expert opinion on empagliflozin/metformin fixed-dose combination for treatment of type 2 diabetes[J].International Journal of Endocrinology and Metabolism,2022,42(06):451.[doi:10.3760/cma.j.cn121383-20220530-05068]

备注/Memo

备注/Memo:
基金项目:广东省级产业技术研究与开发专项(粤财工[2010]207)
更新日期/Last Update: 2014-12-20